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| 1 | Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population显示文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies. | Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 16 |
| 2 | Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring显示文摘反应的氧种类(mitoROS ) 玩的 mitochondrial 的混乱在癌症房间 apoptosis 的一个主要角色。这里,我们设计了 core/shell-structured 有由 photosensitizer (PS ) 涂的核心合并了的做 lanthanide 的 upconversion nanoparticle (UCNP ) 的指向线粒体的基于 upconversion 的使 nano 具有感光性(TPP-UC (PS )) 稠密的硅石壳。有外部在红外线附近的激光(NIR ) 的后面的照耀,在引起为激活的基于 upconversion 的光力学的治疗(UC 太平洋夏季时间) 胀大的严肃的 mitochondrial 矩阵的线粒体的 TPP-UC (PS ) ,和细胞色素 c (cyt c ) 的动员响应增加的 mitoROS 被放大。明确地,这包含 heme cyt c 能被改变 TPP-UC (PS ) s upconversion 光信号(UCL ) 监视,它可以便于在里面为 apoptosis 研究的 cyt c 的 situ 察觉。作为概念的一个证明,我们的设计 TPP-UC (PS ) 可以为在 NIR 刺激下面控制癌症房间 apoptosis 并且为用动态 UCL 学习 apoptosis 提供重要机会,它被本地 cyt c 影响。 | Yanyan Liu Jiawen Zhang Changjing Zuo Zhen Zhang Dalong Ni Chen Zhang Jing Wang Hui Zhang Zhenwei Yao Wenbo Bu | 2016 | Nano Research2016，9，11： | 8 |
| 3 | Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy显示文摘联合治疗是通常基于复杂 nanostructures 的利用,多重部件为 photothermal 作为相片热的精力变换器, photo-sensitizers,或剂量 intensifiers 工作的有希望的癌症治疗策略治疗(PTT ) ,光力学的治疗(太平洋夏季时间) ,或放射治疗(RT ) 。在这研究, ultrathin 钨氧化物 nanowires (W 18 O 49) 用一条 solvothermal 途径被综合并且作为多功能的 theranostic nanoplatform 检验了。在 vitro 并且在 vivo,分析证明这些 nanowires 能导致广泛的热 -- 并且汗衫在 980 nm 在附近下面的癌症房间的调停氧的损坏红外线(NIR ) 激光刺激。他们也被显示作为加强在放射治疗期间局部地并且有选择地提高放热精力免职的代理人的放射剂量工作。独自比作导致 NIR 的 PTT/PDT 和 RT, W 18 O 49-based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2???? ?? ?? 佦 ? 畳 ?? 猯扵￣?? | Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao Wenbo Bu | 2015 | Nano Research2015，8，11： | 5 |
| 4 | Robust Control for Uncertain Nonlinear Feedback Systems Using Operator-based Right Coprime Factorization显示文摘The robust control issue for uncertain nonlinear system is discussed by using the method of right coprime factorization. As it is difficult to obtain the inverse of the right factor due to the high nonlinearity, the proving of the Bezout identity becomes troublesome. Therefore, two sufficient conditions are derived to manage this problem with the nonlinear feedback system as well as that with the uncertain nonlinear feedback system under the definition of Lipschitz norm. A simulation of temperature control is given to demonstrate the validity of the proposed method. | Ni Bu Wei Chen Longguo Jin Yandong Zhao | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，3： | 2 |
| 5 | Effect of bubbles addition on teetered bed separation显示文摘To improve the separation efficiency of a conventional Teetered Bed Separator(TBS) in beneficiation of fine coal with a wide size range,an Aeration TBS(A-TBS) was proposed in this investigation.The bubbles were introduced to A-TBS by a self-priming micro-bubble generator.This study theoretically analyzed the effect of bubbles on the difference in hindered settling terminal velocity between different density particles,investigated the impact of superficial water velocity(V_(SW)) and superficial gas velocity(V_(Sg)) on bed fluidization,and compared the performance of the TBS and A-TBS in treating 1-0.25 mm size fraction particles.The results show that the expansion degree of fluidized bed which was formed by different size particles or has different initial height,is increased by the introduction of bubbles.Compared with the TBS,at the same level of clean coal ash content,the A-TBS shows an increase in the combustible recovery of clean coal,ash content of tailings,and practical separation density by 5.26%,6.56%,and 0.088 g/cm3 respectively,while it shows a decrease in the probable error(E_p) and V_(SW) by 0.031 and 3.51 mm/s,respectively.The addition of bubbles at a proper amount not only improves the separation performance of TBS,but also reduces the upward water velocity. | Ni Chao Xie Guangyuan Liu Bo Bu Xiangning Peng Yaoli Sha Jie | 2015 | International Journal of Mining Science and Technology2015，25，5： | 2 |
| 6 | Passive robust control for uncertain Hamiltonian systems by using operator theory显示文摘In this study,the passivity-based robust control and tracking for Hamiltonian systems with unknown perturbations by using the operator-based robust right coprime factorisation method is concerned.For the system with unknown perturbations,a design scheme is proposed to guarantee the uncertain non-linear systems to be robustly stable while the equivalent non-linear systems is passive,meanwhile the asymptotic tracking property of the plant output is discussed.Moreover,the design scheme can be also used into the general Hamiltonian systems while the simulation is used to further demonstrate the effectiveness of the proposed method. | Ni Bu Yuyi Zhang Xiaoyong Li Wei Chen Changan Jiang | 2022 | CAAI Transactions on Intelligence Technology2022，7，4： | 1 |
| 7 | Anisotropic mechanicalproperties of graphene sheets from molecular dynamics 显示文摘 | NI Z H BU H ZOU M et al | 2010 | PhysicaB2010，405，： | 1 |
| 8 | Concurrent primary angio- sarcoma and invasive ductal carcinoma in the same breast显示文摘 | Ni Y Xie X Bu H | 2013 | J Clin Pathol2013，66，3： | 1 |
| 9 | Anisotropic mechanical properties of grapheme sheets from molecular dynamics显示文摘 | Ni Z Bu H Zou M | | 0，，： | 1 |
| 10 | Anisotropic mechanical properties of grapheme sheets from molecular dynamics 显示文摘 | Ni Z Bu H Zou M | 2010 | Physica B2010，405，5： | 1 |
| 11 | A Polyoxometalate Cluster Paradigm withSelf-Adaptive Electronic Structure for Acidity/Reducibility-SpeciflcPhotothermal Conversion显示文摘 | ZhangC Bu W B Ni D L | 2016 | JAm Chem Soc2016，138，26： | 1 |
| 12 | Our infant ' early hearing detection and intervention guide' how to write 显示文摘 | Huang Lihui Ni Daofeng Bu Hangkuan | 2009 | Journal of Audiology and Speech Pathology2009，10，2： | 1 |
| 13 | Concun'ent primary angiosarcoma and invasive ductal carcinoma in the same breast 显示文摘 | Ni Y Xie X Bu H | 2013 | J Clin Pathol2013，66，3： | 1 |
| 14 | Ordovician Proto-basin in South China and its Tectonic Implications: Evidence from the Detrital Zircon U-Pb Ages of the Ordovician in Central Hunan, China显示文摘Caledonian orogeny is another important tectonic event in South China Block after the breakup of the Rodinia supercontinent.With a view to constrain the tectonic evolution and proto-basin in South China,this paper reports the geochemical and zircon U-Pb dating data of the Ordovician strata in central Hunan,South China.Geochemical features and paleocurrent directions suggest that the lower Ordovician deposited in a passive continental margin basin with a provenance of quartzose components and showing an affinity with the Yangtze Block.U-Pb age data for 260 detrital zircons from upper Ordovician identify three major age populations as:900-1200 Ma,1400-1800 Ma and 2400-2700 Ma.The detrital zircon age spectrum as well as the paleocurrent directions suggest that upper Ordovician deposited in a foreland basin and showing a close affinity with the Cathaysia Block.It is also suggest that the lower Ordovician continuously accepted the mineral from the Yangtze Block,whereas the provenance of the upper Ordovician sedimentary basin changed from the Yangtze Block to the Cathaysia Block.This change implies a tectonic movement,which caused the transformation of the proto-basin in the Hunan area in SCB from passive continental margin basin to foreland basin probably took place during late Ordovician.This fact also demonstrate that the Caledonian orogeny in South China Block began no later than 453 Ma,and a new crustal evolution model is proposed. | ZHANG Jibiao NI Jingbo LIU Yanxue ZHANG Heng BU Ling | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 0 |
| 15 | Build infrastructure in publishing scientific journals to benefit medical scientists显示文摘There is urgent need for medical journals to optimize their publishing processes and strategies to satisfy the huge need for medical scientists to publish their articles,and then obtain better prestige and impact in scientific and research community.These strategies include optimizing the process of peer-review,utilizing open-access publishing models actively,finding ways of saving costs and getting revenue,smartly dealing with research fraud or misconduct,maintaining sound relationship with pharmaceutical companies,and managing to provide relevant and useful information for clinical practitioners and researchers.Scientists,publishers,societies and organizations need to work together to publish internationally renowned medical journals. | Ni Dai Dingyao Xu Xiyao Zhong Li Li Qibo Ling Zhaode Bu | 2014 | Chinese Journal of Cancer Research2014，26，1： | 0 |
| 16 | Visualizing the role of applied voltage in non-metal electrocatalysts显示文摘Understanding how applied voltage drives the electrocatalytic reaction at the nanoscale is a fundamental scientific problem,particularly in non-metallic electrocatalysts,due to their low intrinsic carrier concentration.Herein,using monolayer molybdenum disulfide(MoS_(2))as a model system of non-metallic catalyst,the potential drops across the basal plane of MoS_(2)(△V_(sem))and the electric double layer(△V_(edl))are decoupled quantitatively as a function of applied voltage through in-situ surface potential microscopy.We visualize the evolution of the band structure under liquid conditions and clarify the process of EF keeping moving deep into Ec,revealing the formation process of the electrolyte gating effect.Additionally,electron transfer(ET)imaging reveals that the basal plane exhibits high ET activity,consistent with the results of surface potential measurements.The potential-dependent behavior of kf and ns in the ET reaction are further decoupled based on the measurements of△V_(sem)and△V_(edl).Comparing the ET and hydrogen evolution reaction imaging results suggests that the low electrocatalytic activity of the basal plane is mainly due to the absence of active sites,rather than its electron transfer ability.This study fills an experimental gap in exploring driving forces for electrocatalysis at the nanoscale and addresses the long-standing issue of the inability to decouple charge transfer from catalytic processes. | Ziyuan Wang Jun Chen Chenwei Ni Wei Nie Dongfeng Li Na Ta Deyun Zhang Yimeng Sun Fusai Sun Qian Li Yuran Li Ruotian Chen Tiankai Bu Fengtao Fan Can Li | 2023 | National Science Review2023，10，9： | 0 |
| 17 | Radioanalytical chemistry for nuclear forensics in China:Progress and future perspective显示文摘A relatively new branch of science-nuclear forensics,aiming at providing the nature,origin,history and possible trafficking route of seized nuclear materials/devices,has been established and rapidly developed over decades to screen illicit nuclear activities.This highly interdisciplinary science is built upon a foundation of analytical chemistry,radiochemistry,nuclear physics,material sciences,geology,and other scientific disciplines,within which radiochemical methodologies and radioanalytical techniques play a key role.The present review provides a brief overview about the crucial aspects of nuclear forensics,including basic content,procedure,concerned elements,common separation,analytical method,and so on.The state of the art and recent progresses of nuclear forensics by research communities in China are reviewed,while selected examples and practical applications are emphasized.The challenges associated with this new area and on-going developments are highlighted and discussed. | Yi Liu Xuepeng Shao Wenting Bu Zhen Qin Youyi Ni Fengcheng Wu Chuting Yang Xiaolin Wang | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 18 | Isomorphism-based robust right coprime factorization for uncertain nonlinear feedback systems显示文摘Dear editor,In system engineering,most controlled systems exhibit nonlinear dynamics[1,2],where the exact mathematical model cannot be derived owing to uncertainties such as disturbance.Moreover,the performance of the concerned systems will not be satisfactory by simply approximating them to be linear. | Longguo JIN Ni BU Mingcong DENG | 2020 | Science China(Information Sciences)2020，63，10： | 0 |
| 19 | Synthesis,biochemical evaluation and computational simulations of new cytochrome bc1 complex inhibitors based on N-(4-aryloxyphenyl)phthalimides显示文摘The cytochrome bc_1 complex(the bc_1 complex or complex Ⅲ) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of molecules, N-(4-aryloxyphenyl)phthalimides, were designed and synthesized in a straightforward manner. Our design strategy was to introduce a 4-aryloxyphenyl group, a fragment which exhibited promising bc_1 complex-inhibiting properties, into the aryl group of the valuable N-arylphthalimide backbone. Afterward, the biochemical evaluation of the newly synthesized compounds was carried out,and the results implied that several compounds demonstrated good activities against succinatecytochrome reductase(SCR, a mixture of mitochondrial complex Ⅱ and the bc_1 complex). Further studies confirmed that 3e', a representative compound in this paper, was identified as an inhibitor of the bc_1 complex. Furthermore, computational simulations were also performed to better understand binding of 3e' to the enzyme complex, which indicated that 3e' should bind to the Q_o site of the bc_1 complex.Consequently, we harbor the idea that this paper can provide a solid platform for synthesis and discovery of other bc_1 complex inhibitors. | Hua Cheng Yan Fu Qing Chang Ni Zhang Mengwei Bu Yan Niu Qiongyou Wu Cheng Chen Francis Verpoort | 2018 | Chinese Chemical Letters2018，29，12： | 0 |
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