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| 1 | MAX2 Affects Multiple Hormones to Promote Photornorphogenesis显示文摘Ubiquitin-26S proteasome 系统(不间断电源) 被显示了在轻、调整荷尔蒙的植物生长和开发起中央作用。以前,我们显示出那 MAX2, F 盒子蛋白质,断然响应光调整 photomorphogenic 开发的方面。然而, MAX2 怎么控制这些回答,仍然是未知的。这里,我们证明 MAX2 相对地调整 GA 和骆驼毛的织物生合成响应光优化种子萌芽。Doseresponse 曲线证明 max2 种子对 GA 弱敏并且对在种子萌芽回答的骆驼毛的织物过分敏感。RTPCR 试金证明 GA biosynthetic 基因的表示是下面调整的,当 GA 分解代谢的基因的表示在 max2 种子与相比是起来调整的时野类型。有趣地,两骆驼毛的织物 biosynthetic 的表示和分解代谢的基因在 max2 种子与相比是起来调整的野类型。有一个植物生长素运输禁止者的处理, NPA,证明在 max2 幼苗的那增加的植物生长素运输在光下面贡献长胚轴显型。而且,轻发信号的显型被限制为 max2 作为在 strigolactone 小径, max1, max3,和 max4 的 biosynthetic 异种,没在种子萌芽和幼苗 de 青白化显示任何缺点与相比野类型。一起拿,这些数据建议 MAX2 调制多重荷尔蒙小径影响 photomorphogenesis。 | Hui Shen Ling Zhu Qing-Yun Bu Enamul Huq | 2012 | Molecular Plant2012，5，3： | 14 |
| 2 | Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study显示文摘Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in remission.The primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled study.This subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,respectively.The most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER trial.Teriflunomide has the potential to meet unmet medical needs for MS patients in China. | Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing Dong Hua Peng Chao-Dong Zhang Gang Zhao Yi-Ning Huang Dong Zhou Wei-Ping Wu Bao-Jun Wang Ji-Mei Li Xing-Hu Zhang Yan Cheng Hai-Feng Li Ling Li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu Wan-Li Dong Dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu | 2018 | Chinese Medical Journal2018，，23： | 10 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 5 | Screening of MYH7 gene mutation sites in hypertrophic cardiomyopathy and its significance显示文摘Background:There have been few reports of mutations in the beta-myosin heavy chain(MYH7)gene in hypertrophic cardiomyopathy(HCM),which is associated with sudden cardiac death caused by HCM.This study aimed to screen the mutation sites in the sarcomeric gene MYH7 in Chinese patients with HCM.We also planned to analyze the pathogenicity of the mutation site as well as its significance in clinical and forensic medicine.Methods:From January 2006 to June 2017,autopsy cases were collected from the Department of Pathology,the Affiliated Hospital of Qingdao University.The experiment was to detect MYH gene status in formalin-fixed paraffin-embedded tissues from 18 independent autopsy cases who suffered HCM related sudden death(fatal HCM)and 20 cases without cardiomyopathy.Common mutation exon fragments of MYH7 gene were amplified by polymerase chain reaction.The end-of-deoxygenation method and gene cloning method were further performed to analyze the mutation sites.Homologous comparison among mutant sites was conducted using BLAST online database.Results:The 1336th nucleotide of MYH7 gene at exon 14 was converted from T to G in one HCM case,resulting in the conversion of threonine(Thr)at position 446 to proline(Pro).In another case,the 1402th nucleotide at exon 14 was converted from T to C,resulting in the conversion of phenylalanine(Phe)at position 468 to leucine(Leu).Homologous comparison results showed that the two amino acid residues of Thr446 and Phe468 are highly conserved among different species.Conclusions:Our results showed fatal HCM harbored mutations of Thr446Pro and Phe468Leu in the MYH7 gene.It is significant for clinical and forensic medicine to further explore the functions and detailed mechanisms of these mutations. | Hui-Ting Liu Fang-Fang Ji Ling Wei An-Jun Zuo Yu-Xiu Gao Lin Qi Bu Jin Ji-Gang Wang Peng Zhao | 2019 | Chinese Medical Journal2019，，23： | 3 |
| 6 | Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort显示文摘To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with sAD.Then,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic risk.Receiver operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at onset.We measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the PRSs.We found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our cohort.The PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at onset.Furthermore,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and P-tau.Our study suggests that PRS models hold promise for assessing the genetic risk and development of AD.As genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice. | Wei-Wei Li Zhen Wang Dong-Yu Fan Ying-Ying Shen Dong-Wan Chen Hui-Yun Li Ling Li Heng Yang Yu-Hui Liu Xian-Le Bu Wang-Sheng Jin Fan Zeng Zhi-Qiang Xu Jin-Tai Yu Li-Yong Chen Yan-Jiang Wang | 2020 | Neuroscience Bulletin2020，36，7： | 3 |
| 7 | Hydrothermal synthesis, structure and quantum chemistry of transition metal complex supported by metal-oxo cluster [(Ni(phen)2 2 (ξ-Mo8O26)]显示文摘 | Jiqing Xu Renzhang Wang Chunxiao Guo Guoyu Yang Qingxin Zeng Weiming Bu Ling Ye Yuguo Fan Guangdi Yang | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 8 | Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis显示文摘 | Qiuning Bu Xiaojuan Wang Ling Wang Peng Liu Jiabao Geng Maorong Wang Jian Han Yonghong Zhu Hui Zhuang | 2013 | Archives of Virology2013，，1： | 1 |
| 9 | Analysing complete genome sequence of swine hepatitis E virus (HEV), strain CHN-XJ-SW13 isolated from Xinjiang, China: Putative host range, and disease severity determinants in HEV显示文摘 | Hongwei Fu Ling Wang Yonghong Zhu Jiabao Geng Lingjun Li Xiaojuan Wang Qiuning Bu Hui Zhuang | 2011 | Infection Genetics and Evolution2011，，3： | 1 |
| 10 | Enhancement of immune re-sponse to an HIV env DNA vaccine by a C terminal segment of Listeriolysin O 显示文摘 | Bu ZG Ling Y Marianne JS | 2003 | AIDS Research and Human Retroviruses2003，19，： | 1 |
| 11 | Enhanced cellular immune response against SIV Gag induced by immunization with DNA vac- cines expressing assembly and release-defective SIV Gag proteins 显示文摘 | Bu ZG Ling Y Ziegler HK | 2003 | Virology2003，309，： | 1 |
| 12 | Cavity optimization for investment casting die of turbine blade based on reverse engineering显示文摘 | Ding Hua Zhang Rui Song Jiang Jian Ling Li Wen Hu Wang Kun Bu | 2010 | The International Journal of Advanced Manufacturing Technology2010，，9： | 1 |
| 13 | A finite element method with mesh separation based approximation technique and its application in modeling crack propagation with adaptive mesh refinement 显示文摘 | LING D S BU L F TU F B | 2014 | International Journal for Numerical Methods in Engineering2014，99，7： | 1 |
| 14 | Hydrothermal synthesis, structure and quantum chemistry of transition metal complex supported by metal-oxo cluster [(Ni(phen)2 2 (ξ-Mo8O26)]显示文摘 | Jiqing Xu Renzhang Wang Chunxiao Guo Guoyu Yang Qingxin Zeng Weiming Bu Ling Ye Yuguo Fan Guangdi Yang | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 15 | Chemomics and drug innovation显示文摘Chemomics is an interdisciplinary study using approaches from chemoinformatics,bioinformatics,synthetic chemistry,and other related disciplines.Biological systems make natural products from endogenous small molecules (natural product building blocks) through a sequence of enzyme catalytic reactions.For each reaction,the natural product building blocks may contribute a group of atoms to the target natural product.We describe this group of atoms as a chemoyl.A chemome is the complete set of chemoyls in an organism.Chemomics studies chemomes and the principles of natural product syntheses and evolutions.Driven by survival and reproductive demands,biological systems have developed effective protocols to synthesize natural products in order to respond to environmental changes;this results in biological and chemical diversity.In recent years,it has been realized that one of the bottlenecks in drug discovery is the lack of chemical resources for drug screening.Chemomics may solve this problem by revealing the rules governing the creation of chemical diversity in biological systems,and by developing biomimetic synthesis approaches to make quasi natural product libraries for drug screening.This treatise introduces chemomics and outlines its contents and potential applications in the fields of drug innovation. | XU Jun GU Qiong LIU HaiBo ZHOU JiaJu BU XianZhang HUANG ZhiShu LU Gui LI Ding WEI DongQing WANG Ling GU LianQuan | 2013 | Science China Chemistry2013，56，1： | 1 |
| 16 | Enhancement of immune response to an HIV env DNA vaccine by a C-terminal segment of Listeriolysin O显示文摘 | Bu Z G Ling Y Marianne J S | 2003 | AIDS Res Hum Retroviruses2003，19，5： | 1 |
| 17 | Enhanced cellular immune reponse against SIV Gag induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins显示文摘 | Bu Zhi-gao Ye Ling Ziegler H K | 2003 | Virology2003，309，： | 1 |
| 18 | Enhanced immunogenicity of SIV Gag DNA vaccines encoding chimeric proteins containing a C-terminal segment of Listeriolysin O 显示文摘 | Ling Ye Bu Zhi-gao | 2003 | Virus Res2003，97，： | 1 |
| 19 | Hydrothermal synthesis, structure and quantum chemistry of transition metal complex supported by metal-oxo cluster [(Ni(phen)2 2 (ξ-Mo8O26)]显示文摘 | Jiqing Xu Renzhang Wang Chunxiao Guo Guoyu Yang Qingxin Zeng Weiming Bu Ling Ye Yuguo Fan Guangdi Yang | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 20 | Characterization and activity of visible-light-driven Ti O2photocatalyst codoped with lanthanum and iodine显示文摘 | LI Ling ZHUANG Hui-sheng BU Dan | 2011 | Applied Surface Science2011，257，4： | 1 |
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