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| 1 | A preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers显示文摘Apreliminarystudyonthelossofheterozygosityat17p13ingastricandcolorectalcancersWUGuoJun1,SHANXiangNian2,LIMingFa2,SHIShaoL... | WU Guo Jun 1, SHAN Xiang Nian 2, LI Ming Fa 2, SHI Shao Lin 1, ZHENG Qi Ping 1, YU Long 1 and ZHAO Shou Yuan 1 | 1997 | World Journal of Gastroenterology1997，3，3： | 4 |
| 2 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 3 | Resonance Rayleigh scattering, frequency doubling scattering and second - order scattering spectra of the heparin - crystal violet system and their analytical application显示文摘 | Hong Qun Luo Shao Pu Liu Nian Bing Li | 2002 | Analytiea Chimica Acta2002，468，： | 1 |
| 4 | PTB-associated splicing factor inhibits IGF-l-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy 显示文摘 | Dong L Nian H Shao Y | 2015 | Cell Tissue Res2015，360，2： | 1 |
| 5 | Resonance Rayleigh scattering study of the inclusion complexation of chloramphenicol with β-cyclodextrin显示文摘 | Nian B L Hong Q L Shao P L | 2005 | Talanta2005，66，： | 1 |
| 6 | Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells显示文摘 | Nian H Shao H Zhang G | 2010 | Invest Ophthalmol Vis Sci2010，51，： | 1 |
| 7 | Activated gammadelta T cells promote the activation of uveitogenic T cells and exacerbate EAU development显示文摘 | Nian H Shao H O 'Brien RL | 2011 | Invest Ophthalmol Vis Sci2011，52，： | 1 |
| 8 | Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells显示文摘 | Nian H Shao H Zhang G | | 0，，： | 1 |
| 9 | Multi-chain Fudan-CCDC model for COVID-19—a revisit to Singapore's case显示文摘Background:COVID-19 has been impacting on the whole world critically and constantly since late December 2019.Rapidly increasing infections has raised intense worldwide attention.How to model the evolution of COVID-19 effectively and efficiently is of great significance for prevention and control.Methods:We propose the multi-chain Fudan-CCDC model based on the original single-chain model in[Shao et al.2020]to describe the evolution of COVID-19 in Singapore.Multi-chains can be considered as the superposition of several single chains with different characteristics.We identify the parameters of models by minimizing the penalty function.Results:The numerical simulation results exhibit the multi-chain model performs well on data fitting.Though unsteady the increments are,they could still fall within the range of±30%fluctuation from simulation results.Conclusion:The multi-chain Fudan-CCDC model provides an effective way to early detect the appearance of imported infectors and super spreaders and forecast a second outbreak.It can also explain the data from those countries where the single-chain model shows deviation from the data. | Hanshuang Pan Nian Shao Yue Yan Xinyue Luo Shufen Wang Ling Ye Jin Cheng Wenbin Chen | 2020 | Quantitative Biology2020，8，4： | 1 |
| 10 | Activated -y8T cells promote the activation of uveitogenic T cells and exacerbate EAU development 显示文摘 | Nian H Shao H 0' Brien RL | 2011 | Invest Ophthalmol Vis Sci2011，52，8： | 1 |
| 11 | HYDROXYLATION OF n-HEXANE CATALYZED BY SUPPORTED Mn (Ⅲ)—PORPHYRIN COMPLEXES显示文摘Water-soluble Mn (Ⅲ)-porphyrins supported on various carriers as monooxygenase—like catalysts were used for n—Hexane hydroxylation by PhIO. The hydroxylation yields and XPS measurement of the catalysts indicate that the carriers containing—OH groups have favorable steric and electronic effect on Mn—porphyrins. Some influencing factors and the role of carriers are discussed. | Shao Kai JIANG, Xian Yuan WANG~*, and Guang Nian LI Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu, 610015 Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai, 200032 | 1992 | Chinese Chemical Letters1992，3，7： | 0 |
| 12 | Magnesium single-atom catalysts with superbasicity显示文摘Magnesium-related solid bases have long been considered catalysts with weak or medium basicity.Here we report the fabrication of Mg single-atom catalysts with superbasicity for the first time.A sublimation-migration-anchoring strategy is employed,in which the Mg net is sublimated,transported by Ar,and trapped by defective graphene(producing Mg_(1)/G).Simulated and experimental results demonstrate that Mg single atoms are anchored on graphene in tetra-coordination,and Mg single atoms cooperating with C atoms give superbasicity,which differs from conventional alkali/alkaline earth metal oxides with basicity originating from O atoms.This new solid base is highly active in the synthesis of dimethyl carbonate through transesterification of ethylene carbonate with methanol,which is usually catalyzed by strong bases.The turnover frequency value reaches 99.6 h^(-1) on Mg_(1)/G,which is much higher than that of traditional Mg-related counterparts(1.0–5.6 h^(-1))and even superior to that of typical Na and K-related solid superbases(29.8–36.2 h^(-1))under similar conditions. | Xiang-Bin Shao Yao Nian Song-Song Peng Guo-Song Zhang Meng-Xuan Gu You Han Xiao-Qin Liu Lin-Bing Sun | 2023 | Science China Chemistry2023，66，6： | 0 |
| 13 | Photoinduced Electron Transfer Reaction between Poly-guanylic Acid(5') with Anthraquinone-2-sulfonate显示文摘The electron transfer reaction between triplet anthraquinone-2-sulfonate with poly-guanylic acid (5) (poly[G]) in acetonitrile-H2O has been investigated by 248 nm laser flash photolysis. The transient absorption spectra of radical cation of poly[G] and radical anion of anthraqunione-2-sulfonate (AQS) arising from electron transfer reaction has been observed simultaneously for the first time. The formation processes of radical cation of poly[G] and radical anion of anthraquinone-2-sulfonate as well as the decay processes of triplet anthraquinone-2-sulfonate have also been observed, the apparent rate constants for the formation and decay of transient species have been determined. The free energy changes in the process of the electron transfer was also calculated. | Jian Hua MA Hua SHAO Si De YAO Nian Yun LIN(Department of Chemistry Engineering and Technology, College of Light Industry of Shandong, Jinan 250100)(Laboratory of Radiation Chemistry Shanghai Institute of Nuclear Research, Chinese Academy of Science | 2000 | Chinese Chemical Letters2000，11，6： | 0 |
| 14 | Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial显示文摘An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to enrollment.The participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or BBIBP-CorV.The primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating strains.Between May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV group.Interim results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or 2.For immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by BBIBP-CorV.Our findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages. | Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 15 | Additive Manufacturing of Hydroxyapatite Bioceramic Scaffolds with Projection Based 3D Printing显示文摘Hydroxyapatite(HA)bioceramics have garnered considerable attention owing to their applications in the field of bone repair and excellent biocompatibility.Compared to extrusion-based 3D printing,projection-based 3D print-ing(3DPP)can fabricate parts with complex geometry,high accuracy,and efficiency,which is very promising for bioceramic scaffolds.However,conventional 3DPP using a paste with low viscosity will cause severe shrinkage of the parts after sintering,which makes it unsuitable for bioceramic scaffolds,and a system investigation of the printing process remains insufficient.In this study,we proposed a 3DPP device suitable for bioceramic scaffolds and investigated the additive manufacturing of HA scaffolds.Ceramic paste properties and process parameters of curing,debinding,and sintering were initially examined.The mechanical properties,shrinkage,and biocompati-bility in vitro of the sintered samples were further investigated.The obtained results indicate that HA bioceramics with uniform morphology,complex structure,and high accuracy can be manufactured using the 3DPP equip-ment.HA scaffolds have the mechanical strength of human cancellous bone,while HA scaffolds cultured with osteoblast precursor cells possess strong biocompatibility and can promote osteoblast adhesion,proliferation,and differentiation.These results suggest a promising application of the 3DPP technique in the preparation of bioceramic scaffolds,and the HA scaffolds fabricated using the 3DPP technique exhibit promising potential in fulfilling a constructive role in the biomedical field of human bone regeneration repair. | Huifeng Shao Zhiheng Nian Zhuoluo Jing Tao Zhang Jiahua Zhu Xiang Li Youping Gong Yong He | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，2： | 0 |
| 16 | Antibacterial mechanism and transcriptomic analysis of a nearinfrared triggered upconversion nanoparticles@AgBiS2 for synergetic bacteria-infected therapy显示文摘Methicillin-resistant Staphylococcus aureus(MRSA)has become a rising clinical problem as its occurrence has increased due to the overuse and misuse of antibiotics.In this work,upconversion nanoparticles@AgBiS2 core–shell were produced with enhanced photothermal transformation efficiency and ability to produce reactive oxygen species for synergistic photodynamic photothermal and photodynamic antibacterial performance.The nanoparticles exhibit good antibacterial effects in vitro and satisfactory therapeutic performance on healing MRSA-infected wounds in vivo experiments.RNA-sequencing technique has been used to investigate and reveal that photothermal–photodynamic therapy using the nanoparticles can interfere with metabolic processes such as galactose metabolism in MRSA bacteria,destroy the transport system on the surface of MRSA,and affect quorum sensing to hinder the formation of biofilms to achieve effective antibacterial efficacy.It was demonstrated that this work presents an alternative near-infrared photoactive multimodal nanostructure for antibacterial applications. | Shi Chen Zhaoyou Chu Limian Cao Lingling Xu Qianqian Jin Nian Liu Benjin Chen Ming Fang Wanni Wang Haisheng Qian Min Shao | 2022 | Nano Research2022，15，10： | 0 |
| 17 | Oxidized Dopamine Acrylamide Primer to Achieve Durable Resin-Dentin Bonding显示文摘The durability of the resin-dentin bonding interface is a key issue in clinical esthetic dentistry.Inspired by the extraordinary bioadhesive properties of marine mussels in a wet environment,we designed and synthetized N-2-(3,4-dihydroxylphenyl)acrylamide(DAA)according to the functional domain of mussel adhesive proteins.DAA’s properties of collagen cross-linking,collagenase inhibition,inducing collagen mineralization in vitro,and as a novel prime monomer for clinical dentin adhesion use,its optimal parameters,and effect on the adhesive longevity and the bonding interface’s integrity and mineralization,were evaluated in vitro and in vivo.The results showed that oxide DAA can inhibit the activity of collagenase and cross collagen fibers to improve the anti-enzymatic hydrolysis of collagen fibers and induce intrafibrillar and interfibrillar collagen mineralization.As a primer used in the etch-rinse tooth adhesive system,oxide DAA can improve the durability and integrity of the bonding interface by anti-degradation and mineralization of the exposed collagen matrix.Oxidized DAA(OX-DAA)is a promising primer for improving dentin durability;using 5%OX-DAA ethanol solution and treating the etched dentin surface for 30 s is the optimal choice when used as a primer in the etch-rinse tooth adhesive system. | Leping Wu Hui Shao Yang Tao Jingya Wu Xinhui Wang Qiufeng Nian Shunli Zheng Chris Ying Cao Yuancong Zhao Zheng Zhou Hai Ming Wong Quan-Li Li | 2023 | Research2023，，4： | 0 |
| 18 | Exploring the Feasibility of Machine Learning to Predict Risk Stratification Within 3 Months in Chest Pain Patients with Suspected NSTE-ACS显示文摘Objective We aimed to assess the feasibility and superiority of machine learning(ML)methods to predict the risk of Major Adverse Cardiovascular Events(MACEs)in chest pain patients with NSTE-ACS.Methods Enrolled chest pain patients were from two centers,Beijing Anzhen Emergency Chest Pain Center Beijing Bo’ai Hospital,China Rehabilitation Research Center.Five classifiers were used to develop ML models.Accuracy,Precision,Recall,F-Measure and AUC were used to assess the model performance and prediction effect compared with HEART risk scoring system.Ultimately,ML model constructed by Naïve Bayes was employed to predict the occurrence of MACEs.Results According to learning metrics,ML models constructed by different classifiers were superior over HEART(History,ECG,Age,Risk factors,&Troponin)scoring system when predicting acute myocardial infarction(AMI)and all-cause death.However,according to ROC curves and AUC,ML model constructed by different classifiers performed better than HEART scoring system only in prediction for AMI.Among the five ML algorithms,Linear support vector machine(SVC),Naïve Bayes and Logistic regression classifiers stood out with all Accuracy,Precision,Recall and F-Measure from 0.8 to 1.0 for predicting any event,AMI,revascularization and all-cause death(vs.HEART≤0.78),with AUC from 0.88 to 0.98 for predicting any event,AMI and revascularization(vs.HEART≤0.85).ML model developed by Naïve Bayes predicted that suspected acute coronary syndrome(ACS),abnormal electrocardiogram(ECG),elevated hs-cTn I,sex and smoking were risk factors of MACEs.Conclusion Compared with HEART risk scoring system,the superiority of ML method was demonstrated when employing Linear SVC classifier,Naïve Bayes and Logistic.ML method could be a promising method to predict MACEs in chest pain patients with NSTE-ACS. | ZHENG Zhi Chang YUAN Wei WANG Nian JIANG Bo MA Chun Peng AI Hui WANG Xiao NIE Shao Ping | 2023 | Biomedical and Environmental Sciences2023，36，7： | 0 |
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