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| 1 | Evaluation of a granulated formula for the nerve root type and vertebral artery type of cervical spondylosis:a multicenter,single-blind,randomized,controlled,phase Ⅲ clinical trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis. | Luo Xiaodong Wang Peng Li Zhe Liang De Huang Feng Liu Jinwen Chen Xinyu Hu Guoheng Fang Suting Zhang Huajian | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 28 |
| 2 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 3 | Reconstruction of temperature series of China for the last 1000 years显示文摘This paper reports a study on reconstructing temperature series for ten regions of China over the last 1000 years with a time resolution of 10 a. The regions concerned are: Northeast, North, East, South China, Taiwan, Central, Southwest, Northwest China, Xinjiang and Qinghai-Tibet Plateau. A variety of proxy data, such as ice core, tree-rings, stalagmites, peat, lake sediments, pollen and historical records, were validated with instrumental observations made in the last 120 years, and applied in the recon- struction of the temperature series. A temperature series for whole China is then established by aver- aging the ten regional series with a weighting proportional to the area of each region. Finally, tem- perature variations for the last 1000 years are examined, with special focus placed on the characteris- tics of the Medieval Warm Period (MWP), the Little Ice Age (LIA), and Modern Warming (MW). | WANG ShaoWu WEN XinYu LUO Yong DONG WenJie ZHAO ZongCi YANG Bao | 2007 | Chinese Science Bulletin2007，52，23： | 22 |
| 4 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 5 | A heavy mineral viewpoint on sediment provenance and environment in the Qiongdongnan Basin显示文摘Based on heavy mineral data in core samples from eleven drillings, supplemented by paleontological, element geochemical and seismic data, the evolution of sediment provenance and environment in the Qiongdongnan Basin(QDNB) was analysed. The results show that the basement in the QDNB was predominantly composed of terrigenous sediments. Since the Oligocene the QDNB has gradually undergone transgressions and evolution processes in sedimentary environment from terrestrial-marine transitional to littoral-neritic, neritic, and bathyal roughly. The water depth showed a gradually increasing trend and was generally greater in the southern region than that in the northern region in the same time. With changes in sedimentary environment, provenances of the strata(from the Yacheng Formation to the Yinggehai Formation) showed principal characteristics of multisources, evolving from autochthonous source, short source to distant source step by step. During the Early Oligocene, the sediments were mainly proximal basaltic pyroclastic source and adjacent terrigenous clastic source, afterwards were becoming distant terrigenous clastic sources, including Hainan Island on the north,Yongle Uplift on the south, Shenhu Uplift on the northeast, the Red River System on the northwest and Indochina Peninsula on the southwest, or even a wider region. The Hainan Island provenance began to develop during the Early Oligocene and has become a main provenance in the QDNB since the Middle Miocene. The provenances from Yongle Uplift and Shenhu Uplift most developed from the Late Oligocene to the Early Miocene and gradually subsided during the Middle Miocene. During the Late Miocene, as a main source of sediments filled in the central canyon, the Red River System provenance added to the QDNB massively, whose impact terminated at the end of the Pliocene. The western Yinggehai Basin(YGHB) provenance derived from Indochina Peninsula had developed from the Pliocene on to the Pleistocene. In addition, the material contribution of marine authigenous source to the basin(especially to the southern region) could not be ignored. | LIU Xiaofeng ZHANG Daojun ZHAI Shikui LIU Xinyu CHEN Hongyan LUO Wei LI Na XIU Chun | 2015 | Acta Oceanologica Sinica2015，34，4： | 10 |
| 6 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 7 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 8 | Real-time intelligent big data processing:technology, platform, and applications显示文摘Human beings keep exploring the physical space using information means. Only recently, with the rapid development of information technologies and the increasing accumulation of data, human beings can learn more about the unknown world with data-driven methods. Given data timeliness, there is a growing awareness of the importance of real-time data. There are two categories of technologies accounting for data processing: batching big data and streaming processing, which have not been integrated well. Thus,we propose an innovative incremental processing technology named after Stream Cube to process both big data and stream data. Also, we implement a real-time intelligent data processing system, which is based on real-time acquisition, real-time processing, real-time analysis, and real-time decision-making. The real-time intelligent data processing technology system is equipped with a batching big data platform, data analysis tools, and machine learning models. Based on our applications and analysis, the real-time intelligent data processing system is a crucial solution to the problems of the national society and economy. | Tongya ZHENG Gang CHEN Xinyu WANG Chun CHEN Xingen WANG Sihui LUO | 2019 | Science China(Information Sciences)2019，62，8： | 8 |
| 9 | Geochemical characteristics and their significances of rare-earth elements in deep-water well core at the Lingnan Low Uplift Area of the Qiongdongnan Basin显示文摘A geochemical analysis of rare-earth elements(REEs) in 97 samples collected from the core of deep-water Well LS-A located at the Lingnan Low Uplift Area of the Qiongdongnan Basin is conducted, with the purpose of revealing the changes of sedimentary source and environment in the study region since Oligocene and evaluating the response of geochemical characteristics of REEs to the tectonic evolution. In the core samples, both ∑REE and ∑LREE(LREE is short for light-group REEs) fluctuate in a relatively wide range, while ∑HREE(HREE is short for heavy-group REEs) maintains a relatively stable level. With the stratigraphic chronology becoming newer, both ∑REE and ∑LREE show a gradually rising trend overall. The ∑REE of the core is relatively high from the bottom of Yacheng Formation(at a well depth of 4 207 m) to the top of Ledong Formation, and the REEs show partitioning characteristics of the enrichment of LREE, the stable content of HREE, and the negative anomaly of Eu to varying degrees. Overall the geochemical characteristics of REEs are relatively approximate to those of China's neritic sediments and loess, with significant 'continental orientation'. The ∑REE of the core is relatively low in the lower part of Yacheng Formation(at a well depth of 4 207–4 330 m), as shown by the REEs partitioning characteristics of the depletion of LREE, the relative enrichment of HREE, and the positive anomaly of Eu; the geochemical characteristics of REEs are approximate to those of oceanic crust and basalt overall, indicating that the provenance is primarily composed of volcanic eruption matters. As shown by the analyses based on sequence stratigraphy and mineralogy, the provenance in study region in the early Oligocene mainly resulted from the volcanic materials of the peripheral uplift areas; the continental margin materials from the north contributed only insignificantly; the provenance developed to a certain extent in the late Oligocene. Since the Miocene, the provenance has ceaselessly expanded from proximal to distal realm, embodying a characteristic of multi-source sedimentation. In the core strata with 31.5, 28.4, 25.5, 23, and 16 Ma from today, the geochemical parameters of REEs and Th/Sc ratio have significant saltation, embodying the tectonic movement events in the evolution of the Qiongdongnan Basin. In the tectonic evolution history of the South China Sea, the South China Sea Movement(34–25 Ma BP, early expansion of the South China Sea), Baiyun Movement(23 Ma BP), late expansion movement(23.5–16.5 Ma BP), expansion-settlement transition, and other important events are all clearly recorded by the geochemical characteristics of REEs in the core. | SUN Zhipeng ZHAI Shikui XIU Chun LIU Xinyu ZONG Tong LUO Wei LIU Xiaofeng CHEN Kui LI Na | 2014 | Acta Oceanologica Sinica2014，33，12： | 7 |
| 10 | Synthesis of aminoalkylsilanes with oligo(ethylene oxide) unit as multifunctional electrolyte additives for lithium-ion batteries显示文摘Aminoalkylsilanes with oligo(ethylene oxide) units were designed and synthesized as multifunctional electrolyte additives for lithium-ion batteries. The chemical structures were fully characterized by nuclear magnetic resonance (NMR) spectroscopy and their thermal properties, viscosities, electrochemical windows, and ionic conductivities were systematically measured. With adding one of these compounds (1 vol. %, DSC3N1) in the baseline electrolyte 1.0 M LiPF 6 in EC: DEC (1:1, in volume), Li/LiCoO 2 half cell tests showed an improved cyclability after 100 cycles and improved rate capability at 5C rate condition. Electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), and energy dispersive spectroscopic (EDS) analysis confirmed the acid scavenging function and film forming capability of DSC3N1. These results demonstrated that the multifunctional organosilicon compounds have considerable potential as additives for use in lithium-ion batteries. | WANG JingLun LUO Hao MAI YongJin ZHAO XinYue ZHANG LingZhi | 2013 | Science China Chemistry2013，56，6： | 5 |
| 11 | Characteristics and significance of the penecontemporaneous karst in lacustrine carbonate, Da'anzhai Member, Lower Jurassic, Beibei area, eastern Sichuan Basin显示文摘There are few reports about the penecontemporaneous karst of the lacustrine carbonate of Da'anzhai Member which developed on the top of Lower Jurassic Ziliujing Formation,eastern Sichuan Basin.Based on the analysis of the macroscopic and microscopic characteristics of Heping Reservoir section in Beibei area,It is discovered that the penecontemporaneous karst in the lacustrine carbonate,Da'anzhai Member,and its characters as follows:(1)The dissolved fractures and karrens are common,which have been filled with vadose silts,bioclasts,terrigenous quartzes,crystal and intergrown calcites;(2)The penecontemporaneous karstification mainly occurs in the micrites and shell limestones of the middle and upper part of the shallowing-upward sequence,and the desiccation cracks occur in some shallowing-upward sequences;(3)Three meteoric-water diagenetic lenses are identified in this section.By further study we also find the factures,stylolite and burial dissolution pores occur along the karst system(tubes,conduits and caves of the karst).And the asphalt not only fills the stylolites and fractures,but also is mixed with the vadose silt in the karst system,although the pore space formed by penecontemporaneous karstification is filled with vadose material and cements.Therefore it is concluded that the development and modification of the tight lacustrine carbonate reservoir of Da'anzhai Member,to some extent,are relevant with the penecontemporaneous karstification,and the penecontemporaneous karst reservoir may develop in the buried Da'anzhai carbonate of the basin. | Chengpeng Su Xiucheng Tan Kailan Shi Juan Zou Feifan Lu Sicong Luo Hao Tang Xinyu Zhang | 2017 | Petroleum2017，3，3： | 5 |
| 12 | Biogenic carbonate formation and sedimentation in the Xisha Islands: evidences from living Halimeda显示文摘A recent island survey reveals that the Xuande Atoll and the Yongle Atoll in the Xisha Islands can be classified into one of two systems: the depleted atoll system and growth atoll system; the survey also indicates that the decreased area of several shoals is an unbearable burden for the Xisha Islands, of which the largest island area is 2.13 km2 and the minimum elevation is 1.4 m. According to a survey on the ecological characteristics of Halimeda in the Laolongtou breaker zone of Shidao Island in the Xisha Islands, the green and white living Halimeda are collected,the isotopic ages of 14 C contained in the Halimeda are shown to be 27 years and 55 years, respectively, and carbonate mainly occurs in five types, i.e., luster, segment, sand, sand grain, and marl in the formation. The Halimeda segments mainly provide the carbonate sediments of long-term biogenic deposits in the reef environment and the annual productivity per area is 60–100 g/m2; the characteristics of the microstructure of the Halimeda are analyzed, the aragonite raphide carbonate is deposited and enriched in the cortexes, medullas and cysts, and the Halimeda generally contain major elements such as C, O, Ca, Cl, Mg, K, Na, S and Al, and are rich in trace elements such as tellurium(Te), rhodium(Rh) and strontium. It is believed that the Halimeda grow slowly,including the biotic community of reef corals in the reef areas, thus they possess an environmental remediation capacity, but it takes much time to remedy the environment, and it is necessary to make the law to protect the diversity and vulnerability of the Xisha marine ecology, the ecology of the reef community and the island environment in a scientific way. As indicated in the survey, under the background of global warming and sea-level rise, the discovery of large amounts of Halimeda in the Laolongtou sea area is significant for the natural increase of the depleted atoll system of the Xuande Atoll, while the Halimeda segments represent the primary form of the fossil Halimeda, of which the species can be identified and preserved in great numbers under geological conditions. The Miocene was discovered in large amounts in the Xichen-1 well, therefore the study on the characteristics and mechanism of Halimeda carbonate sediments plays a pivotal role in the formation and construction of organic reefs in the South China Sea as well as oil and gas exploration. | XU Hong ZHAO Xinwei EBERLI G.P. LIU Xinyu ZHU Yurui CAI Ying LUO Wei YAN Guijing ZHANG Bolin WEI Kai SHI Jian | 2015 | Acta Oceanologica Sinica2015，34，4： | 4 |
| 13 | Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays显示文摘The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process. | Bing Deng Zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue Qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng | 2019 | Science Bulletin2019，64，10： | 4 |
| 14 | Principal component analysis and belief-rule-base aided health monitoring method for running gears of high-speed train显示文摘Dear editor,We propose a data-driven health monitoring method for running gears of a high-speed train.In the proposed approach,the principal component analysis(PCA)method is used to perform feature extraction while the belief-rule-base(BRB)method is used to perform health monitoring tasks.To improve the monitoring performance. | Chao CHENG Xinyu QIAO Wanxiu TENG Mingliang GAO Bangcheng ZHANG Xiaojing YIN Hao LUO | 2020 | Science China(Information Sciences)2020，63，9： | 4 |
| 15 | Highly conductive calcium ion-reinforced MXene/sodium alginate aerogel meshes by direct ink writing for electromagnetic interference shielding and Joule heating显示文摘Although MXene sheets possess high electrical conductivity and rich surface chemistry and are well suit-able for fabricating electrically conductive nanocomposites for electromagnetic interference(EMI)shield-ing applications,it remains challenging for MXene nanocomposites to achieve tunable EMI shielding per-formances and customized geometries.Herein,an aqueous MXene/sodium alginate ink is developed to print aerogel meshes with customized geometries using a direct ink writing approach.An ion-enhanced strategy is proposed to reinforce the printed aerogel meshes by multi-level cross-linking.The resultant 3D printed aerogel mesh exhibits an ultrahigh electrical conductivity of 2.85×10^(3)S m^(−1),outstanding mechanical properties,and excellent structural stability in wet environment.More importantly,a wide range of tunable EMI shielding efficiencies from 45 to 100 dB is achieved by the structural design of the 3D printed ion-enhanced MXene/sodium alginate aerogel meshes.As a Joule heater,in addition,the printed aerogel meshes can achieve a wide temperature range of 40-135℃at low driving voltages.This work demonstrates a direct ink writing approach for the fabrication of ion-enhanced MXene/sodium al-ginate aerogel meshes with tunable EMI shielding properties and multi-functionalities for applications in many scenarios. | Cheng-Zhang Qi Xinyu Wu Ji Liu Xin-Jie Luo Hao-Bin Zhang Zhong-Zhen Yu | 2023 | Journal of Materials Science & Technology2023，，4： | 3 |
| 16 | Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era显示文摘Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their high incidence rate, mortality, and treatment costs. Bacteriophage, which constitutes a type of virus that can kill bacteria, is a promising alternative strategy against antibiotic-resistant bacterial infections. Although bacteriophage therapy was first used nearly a century ago, its development came to a standstill after introducing the antibiotics. Nowadays, with the rise in antibiotic resistance, bacteriophage therapy is in the spotlight again.As bacteriophage therapy is safe and has significant anti-bacterial activity, some specific types of bacteriophages(such as bacteriophage phi X174 and Pyo bacteriophage complex liquid) entered into phase Ⅲ clinical trials. Herein, we review the key points of the antibiotic resistance crisis and illustrate the factors that support the renewal of bacteriophage applications. By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced(i) the pharmacological mechanisms and advantages of antibacterial bacteriophages,(ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and(iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development. | Hao Ling Xinyu Lou Qiuhua Luo Zhonggui He Mengchi Sun Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 3 |
| 17 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 18 | Ligand assisted copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines显示文摘Three types of ligands have been developed for copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines in aqueous solution. Ligands with large steric hindrance and strong electron-donating capacity were beneficial to the reaction. UV–Vis and CV analyses demonstrated that these ligands had strong coordination with copper(I), implying the effect of ligand coordination ability on the stability and catalytic activity of catalytic system. | Beibei Shao Hongying Du Xinyu Hao Rongwen Lu Yi Luo Shufen Zhang | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 2 |
| 19 | A Novel Aminoalkylsilane Compound with Oligo(ethylene oxide) Units as Effective Additive for Improving Cyclability of Lithium-ion Batteries显示文摘A new aminoalkylsilane compound,((2-(2-(N,N-dimethylamino)ethoxy)ethoxy) methyl)trimethylsilane(TMSC1N2) based on the oligo(ethylene oxide) chain end-capped with organosilicon functional group and alkylamine group on each end,was introduced as an electrolyte additive for lithium-ion batteries.Electrochemical performances of different volume ratios of TMSC1N2 in the baseline electrolyte were conducted through cyclic voltammetry,electrochemical impedance spectroscopy and galvanostatic charge/discharge tests of lithium-ion batteries.With adding 5 vol.% TMSC1N2 to the baseline electrolyte(1 mol/L LiPF6in ethylene carbonate and diethyl carbonate(EC:DEC 1:1,in volume)),the capacity retention of LiFePO4/Li cells could be significantly improved from 74.7% to 90.8% after 130 cycles.Furthermore,TMSC1N2 showed good compatibility with graphite electrode and would not deteriorate the electrochemical performance of graphite/Li anode cells.These data suggested that TMSC1N2 could be utilized as an effective additive for lithium-ion batteries. | Suqing Wang Jinglun Wang Hao Luo Xinyue Zhao Lingzhi Zhang | 2013 | Journal of Materials Science & Technology2013，29，10： | 2 |
| 20 | A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment显示文摘 | Yufeng Zhao Bo Liu Liyun He Wenjing Bai Xueyun Yu Xinyu Cao Lin Luo Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2017 | Frontiers of Medicine2017，11，3： | 2 |
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