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| 1 | INTEGRATION OF NON-UNIFORM RATIONAL B-SPLINES GEOMETRY AND RATIONAL ABSOLUTE NODAL COORDINATES FORMULATION FINITE ELEMENT ANALYSIS显示文摘This investigation is intended to develop a computer procedure for the integration of NURBS geometry and the rational absolute nodal coordinate formulation(RANCF) finite element analysis. A linear transformation is given that can be used to convert the NURBS curve to RANCF cable element mesh retaining the same geometry and the same degree of continuity, including the discussion of continuity control and mesh refinement. The green strain tensor is used to establish the nonlinear dynamic equations with numerical examples to demonstrate the use of the procedure in the dynamic analysis of flexible bodies. | Peng Lan Zuqing Yu Liang Du Nianli Lu | 2014 | Acta Mechanica Solida Sinica2014，27，5： | 3 |
| 2 | Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies显示文摘Until now,there has been a lack of standard and effective treatments for patients with recurrent malignant tumors or abdominal and pelvic malignancies with extensive invasion(Morris,2000).Generally,these patients face problems such as inability to undergo surgery or chemotherapy resistance(Combs et al.,2016).Re-radiotherapy has achieved a prominent place in the treatment of patients who have received radiotherapy previously and developed in-field recurrences(Straube et al.,2018).However,re-radiotherapy is very complicated,requiring comprehensive consideration of appropriate radiation dose,interval from first radiotherapy,boundary of the radiotherapy target area,and damage to surrounding normal tissues(Straube et al.,2019).In other words,it is necessary to focus on the protection of surrounding normal tissues while maximizing the eflFicacy of re-radiotherapy in such patients. | Xin WEN Hui QIU Zhiying SHAO Guihong LIU Nianli LIU Aoxing CHEN Xingying ZHANG Xin DING Longzhen ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 2 |
| 3 | Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells显示文摘 | Nianli Liu Tianran Chen Xiaohong Wang Darong Yang Binbin Xue Haizhen Zhu | 2015 | FEBS Letters2015，，： | 1 |
| 4 | Inhibition of hepatitis C virus infection by NS5A-specific aptamer显示文摘 | Xiaoyan Yu Yimin Gao Binbin Xue Xiaohong Wang Darong Yang Yuwen Qin Rong Yu Nianli Liu Li Xu Xiaohong Fang Haizhen Zhu | 2014 | Antiviral Research2014，，： | 1 |
| 5 | Buckling of stepped beams with elastic supports 显示文摘 | Zhang Hongsheng Lu Nianli Lan Peng | 2009 | Journal of Harbin Institute of Technology2009，16，： | 1 |
| 6 | An equivalent finite element method to kinetics analysis of complex mechanism显示文摘 | CHE Renwei LU Nianli | 2005 | Journal of Harbin Institute of Technology2005，3，： | 1 |
| 7 | Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field显示文摘Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage.Hydrogel is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix deposition.Efforts have been made to seek suitable scaffolds for cartilage tissue engineering.Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing properties.Gelation time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage repair.Furthermore,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid condition.This granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical situations.Pulsed electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic potentials.PEMF treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue repair.Thereby we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue engineering.In this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were investigated.PEMF treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in vivo.All of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy revealed superior clinical potential for cartilage defect treatment. | Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li | 2023 | Bioactive Materials2023，，4： | 1 |
| 8 | Henrischinins A-C:There New Triterpenoids from Schisan- dra henryi显示文摘 | YONG BOXUE JIAN HONGYANG XIAO NIANLI | 2011 | Organic letters2011，13，6： | 1 |
| 9 | An equivalent finite element method to kinetics analysis of complex mechanism 显示文摘 | CHE Renwei LU Nianli | 2005 | Journal of Harbin Institute of Technology2005，2，： | 1 |
| 10 | Kinematic Characteristics Analysis and Parametric Solving of Snow Melting Agent Throwing Mechanism with Variable Crank Length显示文摘Variable crank length cam⁃linkage mechanism has attracted much attention due to its compact overall structure when realizing complex motion laws.According to the special trajectory requirements,the kinematic characteristics and parameters of the mechanism have been analyzed and solved,which lays foundation for the implementation of the variable crank length snow melting agent throwing mechanism designed in this paper.Based on the trajectory equation of the point,the mathematical model of the throwing mechanism was established,and the theoretical trajectory of the end point of the throwing mechanism was obtained by programming.The parametric modeling and trajectory drawing were carried out by computer aided three⁃dimensional interactive application(CATIA),and the correctness of the mathematical model was verified by comparison.The regional trajectory distribution characteristics of the end points of the throwing mechanism were studied by using the trajectory region location method,and the influence of various parameters on the trajectory was investigated by using the numerical cycle comparison method.The human⁃computer interaction system of snow melting agent throwing mechanism with variable crank length was constructed by using Microsoft Visual Basic(VB)software.Based on the restriction conditions,the optimum combination of structural adjustment parameters and operational parameters suitable for Harbin first⁃class roads was obtained by using orthogonal test table,which provides an effective method to solve the parameters of the variable crank length cam mechanism with smooth impulse trajectory. | Wenwu Liu Nianli Lu Hongxin Liu | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，4： | 0 |
| 11 | Adaptive Sliding Mode Control for the Excavator Manipulator显示文摘An adaptive sliding mode control system for the excavator manipulator during straight line digging operation was presented in this paper.The adaptive laws derived from Lyapunov stability theorem were used to update switching gains and compensate uncertainties.The dynamic model of the excavator manipulator considering link shape and weight was established and the straight line trajectory of the bucket tooth tip of excavator was transformed into the desired joint angle trajectory for direct control.Finally,simulation results showed the superiority of the proposed control scheme compared with traditional variable structure control with sliding mode. | Guosheng Xu Guangming Lv Nianli Lu | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，2： | 0 |
| 12 | Overexpression of RBM34 Promotes Tumor Progression and Correlates with Poor Prognosis of Hepatocellular Carcinoma显示文摘Background and Aims:Emerging evidence suggests that RNA-binding motif(RBM)proteins are involved in hepatocarcinogenesis and act either as oncogenes or tumor suppressors.The objective of this study was to investigate the role of RBM34,an RBM protein,in hepatocellular carcinoma(HCC).Methods:We first examined the expression of RBM34 across cancers.The correlation of RBM34 with clinicopathological features and the prognostic value of RBM34 for HCC was then investigated.Functional enrichment analysis of RBM34-related differentially expressed genes(DEGs)was performed to explore its biological function.RNA sequencing(RNA-seq)was applied to identify downstream genes and pathways affected upon RBM34 knockout.The correlation of RBM34 with immune characteristics was also analyzed.The oncogenic function of RBM34 was examined in in vitro and in vivo experiments.Results:RBM34 was highly expressed in hepatocellular carcinoma and correlated with poor clinicopathological features and prognosis.RBM34 was positively associated with tumor immune cell infiltration,biomarkers of immune cells,and immune checkpoint expression.A positive correlation was also observed between RBM34,T cell exhaustion,and regulatory T cell marker genes.Knockout of RBM34 significantly inhibited cell proliferation,migration,and xenograft tumor growth,and sensitized HCC cells to sorafenib treatment.RBM34 inhibition reduced FGFR2 expression and affected PI3K-AKT pathway activation in HCC cells.Conclusions:Our study suggests that RBM34 may serve as a new prognostic marker and therapeutic target of HCC. | Wei Wang Rui Zhang Ning Feng Longzhen Zhang Nianli Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 0 |
| 13 | Dynamics optimization of a novel high speed and high precision 3-DOF manipulator显示文摘 | 兰朋 Lu Nianli Sun Lining Ding Qingyong | 2006 | High Technology Letters2006，12，1： | 0 |
| 14 | Sustainable Development of Export: Theoretical Meaning, Evaluation Model, and Empirical Research显示文摘With the effect of the human trade doctrine in the international trade field, almost all the countries have paid more attention to the sustainable development of international trade. This article chose the export sustainable development as the research object. On the basis of the analysis of the theoretical connotation of the export sustainable development, this article tried to establish an evaluation indices system and set up an evaluation model of the export sustainable development level, and finally made some empirical research on China. The result indicates that the comprehensive level of the export sustainable development in China showed a tendency to rise from 1985 to 2003 and the export sustainable development level of China in these years can be divided into four grades: excellent, good, moderate and poor. In most years, the social economic benefits of export was obtained at the cost of the deterioration of environment and the depletion of resources, and the economic profit of export did not increase with the enlargement of the export scale because of the deterioration of the terms of trade. Therefore, China should be careful about the problem of poverty accompanied by the increase of export. | Zhou Nianli | 2008 | Chinese Journal of Population,Resources and Environment2008，6，4： | 0 |
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