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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Toward improved trade-off between thermoelectric and mechanical performances in polycarbonate/single-walled carbon nanotube composite films显示文摘Polymer thermoelectric(TE)composites have witnessed explosive developments in recent years,arising from their promising prospect for lightweight flexible electronics and capability of harvesting waste-heat.In sharp contrast with intrinsically conducting polymers(CPs),the insulating thermoplastics have seldom been employed as the matrices for flexible TE composites despite their advantages of low costs,controllable melt-flowing behaviors and excellent mechanical properties.Here,we report flexible films of polycarbonate/single-walled carbon nanotube(PC/SWCNT)composites with improved trade-off between TE and mechanical performances.The SWCNTs with 1D nanostructure were dramatically aligned by PC melt-flowing under hot-pressing in the radial direction.The composite maximum power factor reaches 4.8±0.8μW m^(−1) K^(−2) at 10 wt%SWCNTs in the aligned direction,which is higher than most previously reported thermoplastics-based TE composites at the same SWCNT loading and even comparable to some intrinsically CPs and their composites.In addition,these composites display significantly higher tensile modulus and strength than CPs and their composites.This study paves an effective way to fabricate flexible films of polymer composites with simultaneously high TE and mechanical performances via judicious alignment of SWCNTs in thermoplastic polymers. | Yichuan Zhang Liang Deng Haicai Lv Guangming Chen | 2020 | npj Flexible Electronics2020，4，1： | 3 |
| 3 | Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury显示文摘Skeletal muscle atrophy occurs after denervation. The present study dissected the rat left ventral root and dorsal root at L4-6 or the sciatic nerve to establish a model of simple motor nerve injury, sensory nerve injury or mixed nerve injury. Results showed that with prolonged denervation time, rats with simple motor nerve injury, sensory nerve injury or mixed nerve injury exhibited abnormal behavior, reduced wet weight of the left gastrocnemius muscle, decreased diameter and cross-sectional area and altered ultrastructure of muscle cells, as well as decreased cross-sectional area and increased gray scale of the gastrocnemius muscle motor end plate. Moreover, at the same time point, the pathological changes were most severe in mixed nerve injury, followed by simple motor nerve injury, and the changes in simple sensory nerve injury were the mildest. These findings indicate that normal skeletal muscle morphology is maintained by intact innervation. Motor nerve injury resulted in larger damage to skeletal muscle and more severe atrophy than sensory nerve injury. Thus, reconstruction of motor nerves should be considered first in the clinical treatment of skeletal muscle atrophy caused by denervation. | Lei Zhao Guangming Lv Shengyang Jiang Zhiqiang Yan Junming Sun Ling Wang Donglin Jiang | 2012 | Neural Regeneration Research2012，7，32： | 3 |
| 4 | Regulating Thermogalvanic Effect and Mechanical Robustness via Redox Ions for Flexible Quasi‑Solid‑State Thermocells显示文摘The design of power supply systems for wearable applications requires both flexibility and durability.Thermoelectrochemical cells(TECs)with large Seebeck coefficient can efficiently convert lowgrade heat into electricity,thus having attracted considerable attention in recent years.Utilizing hydrogel electrolyte essentially addresses the electrolyte leakage and complicated packaging issues existing in conventional liquid-based TECs,which well satisfies the need for flexibility.Whereas,the concern of mechanical robustness to ensure stable energy output remains yet to be addressed.Herein,a flexible quasisolid-state TEC is proposed based on the rational design of a hydrogel electrolyte,of which the thermogalvanic effect and mechanical robustness are simultaneously regulated via the multivalent ions of a redox couple.The introduced redox ions not only endow the hydrogel with excellent heat-to-electricity conversion capability,but also act as ionic crosslinks to afford a dual-crosslinked structure,resulting in reversible bonds for effective energy dissipation.The optimized TEC exhibits a high Seebeck coefficient of 1.43 mV K−1 and a significantly improved fracture toughness of 3555 J m^(−2),thereby can maintain a stable thermoelectrochemical performance against various harsh mechanical stimuli.This study reveals the high potential of the quasi-solid-state TEC as a flexible and durable energy supply system for wearable applications. | Peng Peng Jiaqian Zhou Lirong Liang Xuan Huang Haicai Lv Zhuoxin Liu Guangming Chen | 2022 | Nano-Micro Letters2022，14，5： | 2 |
| 5 | Biotinylated dextran amine anterograde tracing of the canine corticospinal tract显示文摘In this study, biotinylated dextran amine (BDA) was microinjected into the left cortical motor area of the canine brain. Fluorescence microscopy results showed that a large amount of BDA-labeled pyramidal cells were visible in the left cortical motor area after injection. In the left medulla oblongata, the BDA-labeled corticospinal tract was evenly distributed, with green fluorescence that had a clear boundary with the surrounding tissue. The BDA-positive corticospinal tract entered into the right lateral funiculus of the spinal cord and descended into the posterior part of the right lateral funiculus, close to the posterior horn, from cervical to sacral segments. There was a small amount of green fluorescence in the sacral segment. The distribution of BDA labeling in the canine central nervous system was consistent with the course of the corticospinal tract. Fluorescence labeling for BDA gradually diminished with time after injection. Our findings indicate that the BDA anterograde tracing technique can be used to visualize the localization and trajectory of the corticospinal tract in the canine central nervous system. | Xiao Han Guangming Lv Huiqun Wu Dafeng Ji Zhou Sun Yaofu Li Lemin Tang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 6 | Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer显示文摘Dear Editor,Lung cancer is the predominant cause of cancer-related death worldwide[1].Non-small cell lung cancer accounts for 80%-85%and small cell lung cancer(SCLC)accounts for 15%-20%of all lung cancer cases[2].Patients with SCLC,a highly aggressive and poorly differentiated malignancy,have an alarming average 5-year overall sur-vival rate of less than 10%[3].Most patients with SCLC already show clinically detectable metastases at diag-nosis and have extremely poor prognoses,even when treated with multimodality therapy[4].Before the addi-tion of atezolizumab to chemotherapy became the first-line treatment of extensive-stage SCLC,chemotherapy is the primary treatment of SCLC[5]. | Jie Zhang Chen Tian Fang Lv Jianfei Wang Wenbo Han Jun Nie Ling Dai Weiheng Hu Xiaoling Chen Xiangjuan Ma Guangming Tian Di Wu Sen Han Yang Wang Jieran Long Ziran Zhang Jian Fang Henghui Zhang | 2019 | Cancer Communications2019，39，1： | 2 |
| 7 | Estrogen inhibits lipid peroxidation after hypoxic-ischemic brain damage in neonatal rats显示文摘Sprague-Dawley neonatal rats within 7 days after birth were used in this study. The left common carotid artery was occluded and rats were housed in an 8% O2 environment for 2 hours to establish a hypoxic-ischemic brain damage model. 17β-estradiol (1 × 10-5 M) was injected into the rat abdominal cavity after the model was successfully established. The left hemisphere was obtained at 12, 24, 48, 72 hours after operation. Results showed that malondialdehyde content in the left brain of neonatal rats gradually increased as modeling time prolonged, while malondialdehyde content of 17β-estrodial-treated rats significantly declined by 24 hours, reached lowest levels at 48 hours, and then peaked at 72 hours after injury. Nicotinamide-adenine dinucleotide phosphate histochemical staining showed the nitric oxide synthase-positive cells and fibers dyed blue/violet and were mainly distributed in the cortex, hippocampus and medial septal nuclei. The number of nitric oxide synthase-positive cells peaked at 48 hours and significantly decreased after 17β-estrodial treatment. Our experimental findings indicate that estrogen plays a protective role following hypoxic-ischemic brain damage by alleviating lipid peroxidation through reducing the expression of nitric oxide synthase and the content of malondialdehyde. | Hui Zhu Xiao Han Dafeng Ji Guangming Lv Meiyu Xu | 2012 | Neural Regeneration Research2012，7，31： | 1 |
| 8 | Application and Research of Latex Tenacity Cement Slurry SystemSun Fuquan显示文摘 | Lv Guangming Jin Jianzhou | 2006 | SPE1044342006，，： | 1 |
| 9 | Influence of ultrasonic field on microcystins produced by bloom-forming algae显示文摘 | Bozhi Ma Yifang Chen Hongwei Hao Minsheng Wu Bo Wang Honggang Lv Guangming Zhang | 2004 | Colloids and Surfaces B: Biointerfaces2004，，2： | 1 |
| 10 | Highly active nanoscale zero-valent iron (nZVI)–Fe 3 O 4 nanocomposites for the removal of chromium(VI) from aqueous solutions显示文摘 | Xiaoshu Lv Jiang Xu Guangming Jiang Jie Tang Xinhua Xu | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 11 | 有到在氧减小反应的磅的一项优异活动的核心 / 壳 FePd/Pd 催化剂显示文摘开发高度有效的非铂(磅) 催化剂因为氧减小反应(ORR ) 是钥匙减少磅的用法,钯(Pd ) 基于催化剂是一种有希望的选择。这里,我们介绍了一条灵巧的途径给核心 / 壳 FePd/Pd nanoparticle (NP ) 有 FePd 核心在的催化剂化学上订了以脸为中心四角形(fct-) 在从 0.32 ~ 0.81 的控制厚度的结构和壳 ? 经由 FePd NP 的热退火的 nm 由一个电镀物品阳极化过程列在后面。与一 0.71 ?nm厚的 Pd 壳, fct-FePd/Pd 在 0.85 和 0.90 点与集体活动为 ORR 显示出一项柔韧的催化活动和耐久性?到达 453 和 96.7 的 V ? A/mg Pd ,分别地,它比在碱的媒介的商业磅的那些高大约 3.0 和 2.1 倍。这个工作与优异性能介绍非磅催化剂的一个新班给磅因为这里表明的 ORR 催化作用,和策略能被扩大为另外的化学反应设计高度有效的催化剂。 | Guangming Jiang Xinwei Li Xiaoshu Lv Ling Chen | 2016 | Science Bulletin2016，61，16： | 1 |
| 12 | Highly active nanoscale zero-valent iron(n ZVI)-Fe3O4 nanocomposites for the removal of chromium(Ⅵ)from aqueous solutions显示文摘 | Lv Xiaoshu Xu Jiang Jiang Guangming | 2012 | 369(1):460-4692012，369，1： | 1 |
| 13 | Determinationof chromosomal ploidy in Agaves ssp 显示文摘 | Lingling Lv Guangming Sun Jianghui Xie | 2009 | African Journal ofBiotechnology2009，8，20： | 1 |
| 14 | A Wavy-Structured Highly Stretchable Thermoelectric Generator with Stable Energy Output and Self-Rescuing Capability显示文摘Thermoelectric generators(TEGs)demonstrate great potential for flexible and wearable electronics due to the direct electrical energy harvested from waste heat.Good wearability requires high mechanical flexibility and preferable stretchability,while current TEGs are primarily developed with rigid or non-stretchable components,which do not conform well to human skin or accommodate human motions,thus hindering further applications. | Zhuoxin Liu Xiaodong Wang Shasha Wei Haicai Lv Jiaqian Zhou Peng Peng Hanfu Wang Guangming Chen | 2021 | CCS Chemistry2021，3，10： | 1 |
| 15 | 应用组织微阵列技术检测KiSS-1和KAI-1在胆囊癌中的表达(英文)显示文摘Objective: We investigated the expression levels of KiSS-1 and KAI-1 in gallbladder carcinoma and their relationship with clinicopathologic parameters and metastasis potential. Methods: Pathological specimens from 59 gallbladder carcinoma tissues (including 23 invasion tissues), matched 7 para-tumor and 6 normal gallbladder tissues were examined for the expression of KiSS-1 and KAI-1 protein by tissue microarray technique and immunohistochemistry (EnVision). Results: The positive rate of KiSS-1 and KAI-1 was down-regulated (P < 0.05) in tumor tissues, compared with non-tumor tissues. The positive rate of KiSS-1 and KAI-1 were down-regulated (P < 0.01) in invasion tissues, compared with para-tumor tissues. Down-regulating expression levels of KiSS-1 and KAI-1 were significantly correlated with some malignant behavior of gallbladder carcinoma. The positive rate of KiSS-1 and KAI-1 were all negatively correlated with the Nevin staging of gallbladder carcinoma (P < 0.01). Moreover, a strong positive correlation was found between the positive expression of KiSS-1 and KAI-1 in gallbladder carcinoma (P < 0.001). It was indicated that KiSS-1 and KAI-1 were all associated with high metastasis potential of gallbladder carcinoma. Conclusion: KiSS-1 and/or KAI-1 may be important markers of reflecting invasive and metastatic potential and prognosis in gallbladder carcinoma, and may be the target genes to inhibit metastasis of gallbladder carcinoma. Detection of the expression of KiSS-1 and/or KAI-1 may have important clinical value for finding early-stage and evaluating the prognosis of gallbladder carcinoma. | Zhiqiang Lv Quangen Gao Jianping Qju Guangming Zhao Canrong Ni Guanzhen Yu Houzhong Ding | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，6： | 0 |
| 16 | Adaptive Sliding Mode Control for the Excavator Manipulator显示文摘An adaptive sliding mode control system for the excavator manipulator during straight line digging operation was presented in this paper.The adaptive laws derived from Lyapunov stability theorem were used to update switching gains and compensate uncertainties.The dynamic model of the excavator manipulator considering link shape and weight was established and the straight line trajectory of the bucket tooth tip of excavator was transformed into the desired joint angle trajectory for direct control.Finally,simulation results showed the superiority of the proposed control scheme compared with traditional variable structure control with sliding mode. | Guosheng Xu Guangming Lv Nianli Lu | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，2： | 0 |
| 17 | Strong interface interaction and internal electric field promote electron transfer of Bi_(2)O_(2)S/NiFe_(2)O_(4) heterojunction for photocatalytic antibiotic degradation显示文摘Heterojunction photocatalysts have shown considerable activities for organic pollutants degradation.However,the faint connection interface and inferior charge shift efficiency critically block the property of heterojunction photocatalysis.Herein,Bi_(2)O_(2)S/NiFe_(2)O_(4) nanosheets heterojunction with ultrastrong inter-face interaction and high internal electric field are designed by an in-situ growth method.Tentative and theoretical consequences prove that the interfacial interaction and internal electric field not only act as the electron flow bridge but also decrease the electrons shift energy obstacle,thus speeding up electrons transfer and achieving effective spatial electron-hole separation.Therefore,a large amount of·O_(2)^(-)and holes as active species were generated.Remarkably,Bi_(2)O_(2) S/NiFe_(2)O_(4) establishes a considerably boosted photocatalytic performance for tetracycline degradation(0.032 min^(-1)),which is about 14.2-fold and 7.8-fold of the pristine BOS and NFO,respectively.This work provides a promising motivation for modulating charge transfer by interface control and internal electric field to boost photocatalytic performance. | Shaoxuan Pang Yilin Dong Dongyu Xu Qiuwen Wang Weihong Gao Lijun Zhang Kang Wang Guangming Zhang Longyi Lv Yuguo Xia Zhijun Ren Pengfei Wang | 2023 | Journal of Materials Science & Technology2023，，27： | 0 |
| 18 | Investigation of the Effect of Metallic Lewis Acid on the Nitrolysis of [3,7-Diacetyl-1,3,5,7-tetraazabicyclo(3.3.1)- nonane] and Hexamine显示文摘DAPT 的 nitrolysis 上的金属性的离子的效果[3,7-diacetyl-1,3,5,7-tetraazabicyclo (3.3.1 ) nonane ] 并且哈(hexamine ) 被试验性、理论的途径调查。组合试剂, M (没有 ? 3 ) n/Ac2/NH4NO3 (M=Mg2+ , Cu2+ , Pb2+ , Bi3+ , Fe3+ 和 Zr4+) ,被发现在 DAPT 的 nitrolysis 的实验有效。在 DAPT 的 nitrolysis 期间中间的一把钥匙被 1H NMR 检测。中介的形成机制被建议并且分析。DAPT 的 nitrolysis 的一些差异的结果并且哈由不同金属性的硝酸盐催化基于难软、酸硷的原则被解释并且稳定了离子建筑群的精力。从后者观点,有高 polarizable ligands 的一些阳离子,例如, OSO2CF3 ? ,(CF3SO2 ) 2N ? ,并且(C4F9SO2 ) 2N ? ,能增加收益。二最新设计的催化剂, Cu [(CF3SO2 ) 2N ] 2 并且 Cu [(C4F9SO2 ) 2N ] 2,被测试高度有效。 | Shi Liangwei Yu Menglong Zhang Yazhu Qin Guangming Lv Jian Zhao Gang | 2011 | Chinese Journal of Chemistry2011，29，2： | 0 |
| 19 | Fluoro-ruby retrograde tracing and three-dimensional visualization of the corticospinal tract in the guinea pig显示文摘Fluoro-ruby was injected into the posterior funiculus of the spinal cord in the cervical(C5-T2) and lumbar(L3-6) segments of adult guinea pigs.The spinal cord was cut into serial frozen sections.The Fluoro-ruby labeling was clearly delineated from the surrounding structure.The labeling traversed the cervical,thoracic and lumbar segments,and was located on the ventral portion of the posterior funiculus on the injected side,proximal to the intermediate zone of the dorsal gray matter.The fluorescence area narrowed rostro-caudally.The spinal cord,spinal cord gray matter and corticospinal tract were reconstructed using 3D-DOCTOR 4.0 software,resulting in a robust three-dimensional profile.Using functionality provided by the reconstruction software,free multi-angle observation and sectioning could be conducted on the spinal cord and corticospinal tract.Our experimental findings indicate that the Fluoro-ruby retrograde fluorescent tracing technique can accurately display the anatomical location of corticospinal tract in the guinea pig and that three-dimensional reconstruction software can be used to provide a three-dimensional image of the corticospinal tract. | Xiao Han Lulian Xu Yue Wu Hua Xun Jinxiu Pan Yingying Huang Dafeng Ji Huiqun Wu Guangming Lv Lemin Tang | 2012 | Neural Regeneration Research2012，7，5： | 0 |
| 20 | Construction of a cement-rebar nanoarchitecture for a solution-processed and flexible film of a Bi_(2)Te_(3)/CNT hybrid toward low thermal conductivity and high thermoelectric performance显示文摘Solution processability and flexibility still remain major challenges for many thermoelectric(TE)materials,including bismuth telluride(Bi_(2)Te_(3)),a typical and commercially available TE material.Here,we report a new solutionprocessed method to prepare a flexible film of a Bi_(2)Te_(3)/single-walled carbon nanotube(SWCNT)hybrid,where the dissolved Bi_(2)Te_(3) ion precursors are mixed with dispersed SWCNTs in solution and recrystallized on the SWCNT surfaces to form a“cement-rebar”-like architecture.The hybrid film shows an n-type characteristic,with a stable Seebeck coefficient of^(−1)00.00±1.69μVK^(−1) in air.Furthermore,an extremely low in-plane thermal conductivity of∼0.33Wm^(−1) K^(−1) is achieved at 300 K,and the figure of merit(ZT)reaches 0.47±0.02.In addition,the TE performance is independent of mechanical bending.The unique“cement-rebar”-like architecture is believed to be responsible for the excellent TE performances and the high flexibility.The results provide a new avenue for the fabrication of solution-processable and flexible TE hybrid films and will speed up the applications of flexible electronics and energy conversion. | Zhijun Chen Haicai Lv Qichun Zhang Hanfu Wang Guangming Chen | 2022 | Carbon Energy2022，4，1： | 0 |
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