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| 1 | Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats显示文摘 | Shufeng Tan Guofu Wang Yongping Guo Dingkun Gui Niansong Wang Angelo Antonio Izzo | 2013 | <journal-title>Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 2 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 3 | RF energy harvesting system for wireless intraocular pressure monitoring显示文摘This paper presents an RF energy harvesting system for wireless intraocular pressure monitoring applications.The system consists of an implantable antenna and a rectifier.A new sizing strategy is adopted to optimize the conversion efficiency of the rectifier,and the design principle of an implantable antenna is introduced from material selection and structure design.Results from testing demonstrate that the antenna gain is about-20 dBi and the rectifier's maximum total conversion efficiency which contains match efficiency and rectifying efficiency is 47.18%under the implementation of0.18μm standard CMOS process.The maximum power obtained from the proposed system is 8μW when the power density of electromagnetic wave is lower than the national standard 40μW/cm^2 at915 MHz,which is enough to power the intraocular pressure monitoring system. | 刘德盟 Mei Niansong Zhang Zhaofeng | 2015 | High Technology Letters2015，21，2： | 1 |
| 4 | Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways显示文摘 | Dingkun Gui Jianhua Huang Wei Liu Yongping Guo Wenzhen Xiao Niansong Wang | 2013 | Apoptosis2013，，4： | 1 |
| 5 | Pro12ala polymorphism in thepparggene contributes to the development of diabetic nephropathy in chinese type 2 diabetic patients显示文摘 | Limei liu Taishan zheng Feng wang Niansong wa | | 0，，01： | 1 |
| 6 | Hypertension: an immunologic disease?显示文摘 | Tao Xing Feng Wang Junhui Li Niansong Wang | 2012 | Journal of Hypertension2012，，12： | 1 |
| 7 | Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer显示文摘 | Yu Tang Xiangtian Zeng Fei He Yonghui Liao Niansong Qian Masakazu Toi | 2012 | Medical Oncology2012，，2： | 1 |
| 8 | Breast cancer stem-like cells and breast cancer therapy显示文摘Until the early 1990s,human cancers were considered a morphologically heterogeneous population of cells.In 1997,Bonnet et al[1] demonstrated that a small population of leukemia cells was able to differentiate in vivo into leukemic blasts,indicating that the leukemic clone was organized as a hierarchy;this was subsequently denoted as | Niansong Qian Nobuko Kawaguchi-Sakita Masakazu Toi | 2010 | 中华乳腺病杂志(电子版)2010，4，5： | 0 |
| 9 | Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity显示文摘Background:Gene promoter methylation is a major epigenetic change in cancers,which plays critical roles in carcinogenesis.As a crucial regulator in the early stages of B-cell differentiation and embryonic neurodevelopment,the paired box 5(PAX5)gene is downregulated by methylation in several kinds of tumors and the role of this downregulation in esophageal squamous cell carcinoma(ESCC)pathogenesis remains unclear.Methods:To elucidate the role of PAX5 in ESCC,eight ESCC cell lines,51 primary ESCC tissue samples,and eight normal esophageal mucosa samples were studied and The Cancer Genome Atlas(TCGA)was queried.PAX5 expression was examined by reverse transcription-polymerase chain reaction and western blotting.Cell apoptosis,proliferation,and chemosensitivity were detected by flow cytometry,colony formation assays,and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assays in ESCC cell lines with PAX5 overexpression or silencing.Tumor xenograft models were established for in vivo verification.Results:PAX5 methylation was found in 37.3%(19/51)of primary ESCC samples,which was significantly associated with age(P=0.007)and tumor-node-metastasis stage(P=0.014).TCGA data analysis indicated that PAX5 expression was inversely correlated with promoter region methylation(r=-0.189,P=0.011 for cg00464519 and r=-0.228,P=0.002 for cg02538199).Restoration of PAX5 expression suppressed cell proliferation,promoted apoptosis,and inhibited tumor growth of ESCC cell lines,which was verified in xenografted mice.Ectopic PAX5 expression significantly increased p53 reporter luciferase activity and increased p53 messenger RNA and protein levels.A direct interaction of PAX5 with the p53 promoter region was confirmed by chromatin immunoprecipitation assays.Re-expression of PAX5 sensitized ESCC cell lines KYSE150 and KYSE30 to fluorouracil and docetaxel.Silencing of PAX5 induced resistance of KYSE450 cells to these drugs.Conclusions:As a tumor suppressor gene regulated by promoter region methylation in human ESCC,PAX5 inhibits proliferation,promotes apoptosis,and induces activation of p53 signaling.PAX5 may serve as a chemosensitive marker of ESCC. | Weiwei Zhang Wenji Yan Niansong Qian Quanli Han Weitao Zhang Guanghai Dai | 2022 | Chinese Medical Journal2022，，5： | 0 |
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