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| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Central monoaminergic systems are a site of convergence of signals conveying the experience of exercise to brain circuits involved in cognition and emotional behavior显示文摘 | Toni M. NICASTRO Benjamin N. GREENWOOD | 2016 | Current Zoology2016，62，3： | 2 |
| 3 | A new treatment for premature ejaculation:the rehabilitation of the pelvic floor显示文摘 | La Pera G Nicastro A | 1996 | J Sex Marital Ther1996，22，1： | 1 |
| 4 | New views of cells in 3D: an introduction to electron tomography 显示文摘 | McIntosh R Nicastro D Mastronarde D | 2005 | Trends in Cell Biology2005，15，： | 1 |
| 5 | Influence of attention on an auditory-verbal learning test in schizophrenic patients显示文摘 | Huguelet P Nicastro R Zanello A | 2002 | Encephale2002，28，4： | 1 |
| 6 | Genotypic characterisation of thermophilic bacilli:a study on new soil isolates and several reference strains 显示文摘 | Mora B Fortina MG Nicastro G | 1998 | Reserch Microbiology1998，149，10： | 1 |
| 7 | Is autosomal recessive deafness associated with oculocutaneous albinism a “coincidence syndrome”? 显示文摘 | Lezirovitz K Nicastro F S Pardono E | 2006 | J Hum Genet2006，51，： | 1 |
| 8 | Para and perirenal fat thickness is an independent predictor of chro- nic kidney disease,increased renal resistance index and hype- ruricaemia in type-2 diabetic patients 显示文摘 | LAMACCHIA O NICASTRO V CAMARCHIO D | 2011 | Nephrol Dial Trans- plant2011，26，3： | 1 |
| 9 | The role of MRI in traumatic rupture of the diaphragm our experience in three cases and review显示文摘 | Barbiera F Nicastro N Firazzo M | 2003 | Radiol Med2003，105，3： | 1 |
| 10 | Genotypic characterisation of thermophilic bacilli:a study on new soil isolates and several reference Strains显示文摘 | MORA B FORTINA MG NICASTRO G | | 0，，： | 1 |
| 11 | The radio afterglow from the Gamma-ray burst of 8 May 1997显示文摘 | FRAIL D KULKARNI S R NICASTRO S R | 1997 | Nature1997，389，： | 1 |
| 12 | Mindfulness skills in border- line personality disorder patients during dialectical behavior therapy: preliminary results 显示文摘 | Perroud N Nicastro R Jermann F | 2012 | Int J Psychiatry Clin Pract2012，16，3： | 1 |
| 13 | Para and perire nal fat thickness is an independent predictor of chronic kidney disease,increased renal resistance index and hyperuricaemia in type- 2 diabetic patients显示文摘 | Lamacchia O Nicastro V Camarchio D | 2011 | Nephrol Dial Transplant2011，26，3： | 1 |
| 14 | Influence of attention on an auditory-verbal learning test in schizophrenic patients显示文摘 | Huguelet P Nicastro R Zanello A | 2002 | Encephale2002，28，4： | 1 |
| 15 | Genotype - phenotype correlation in Italian children with Wilson's disease显示文摘 | Nicastro E Loudianos G Zancan L | 2008 | J Hepatol2008，50，3： | 1 |
| 16 | Experimental berification of scaling relationships for fluidized beds显示文摘 | NICASTRO M T GLICKSMAN L R | 1984 | Chemical engineering science1984，，39： | 1 |
| 17 | Exchange Coupling in CaMnO3 and LaMnO3 : Configuration Interaction and the Coupling Mechanism显示文摘 | Nicastro M Patterson C H | 2002 | Physical Review B2002，65，20： | 1 |
| 18 | Stimulation of camitine palmitoyltransferase 1 improves renal function and attenuates tis sue damage after ischemia/reperfusion显示文摘 | Idrovo JP Yang WL Nicastro J | | 0，，1： | 1 |
| 19 | Milbemectin Resistance in Tetranychus urticae(Acari: Tetranychidae): Selection, Stabilityand Cross-resistance to Abameetin显示文摘 | NICASTRO L ME S MZ D S | 2010 | J Exp Appl Acarol2010，50，： | 1 |
| 20 | Genotypic charac- terisation of thermophilic bacilli: a study on new soil iso- lates and several reference strains 显示文摘 | Mora B Fortina M G Nicastro G | 1998 | Res Microbiol1998，149，10： | 1 |
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