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| 1 | A Critical Role of AMT2;1 in Root-To-Shoot Translocation of Ammonium in Arabidopsis显示文摘在植物根的铵举起被 AMT/MEP/Rh-type 铵 transporters 调停。从在 Arabidopsis 根被表示的五 AMT,四 AMT1 类型 transporters 而没有生理的功能到目前为止被分到属于 MEP 亚科的唯一的相当或相同的事物,贡献铵举起, AMT2; 1。基于在铵供应下面,抄本 AMT2 铺平的观察; 1 增加了,它的倡导者活动优先地变了到 pericycle,我们估计了 AMT2 的贡献; 1 到木部装载。当暴露了到 15标记 N 的铵, amt2; 1 变异的线 translocated 更少 tracer 到射击和在木部树液的包含的更少铵。而且,在 amt1 ; 1 amt1 ; 2 amt1 ; 3 amt2 ; 1 四倍的异种( qko ), AMT2 的合作表示; 1 与任何一个 AMT1 ; 2 或 AMT1 ; 3 显著地提高的 15 N translocation 到射击,显示在 AMT2 之间的一个合作行动; 1 并且 AMT1 transporters 。在 N 缺乏下面, proAMT2; 1-GFP 线在外皮的根房间主要显示出提高的倡导者活动,它与一致,提高的铵流入由 AMT2 交谈了; 1 在 millimolar 底层集中。我们的结果除了在低亲密关系的范围中等作出贡献到根举起显示那, AMT2;主要在铵的 root-to-shoot translocation 的 1 个函数,响应 ?植物取决于它的 cell-type-specific 表达式营养的地位并且到本地铵坡度。 | Ricardo F.H. Giehl Alberto M. Laginha Fengying Duan Doris Rentsch Lixing Yuan Nicolaus von Wirén | 2017 | Molecular Plant2017，10，11： | 10 |
| 2 | 感染模型家兔体内莫西沙星的药动学显示文摘目的 :研究莫西沙星在感染家兔模型中的药物动力学。方法 :8只家兔经埴入高尔夫练习球并用肺炎链球菌感染 3d后 ,用多剂量口服莫西沙星治疗 ,第 5天进行药动学试验。用高效液相色谱法测定血药浓度。结果 :莫西沙星在家兔体内属线性药物并符合二房室模型 ;达峰时间为 (1.2± 0 .6)h ,峰浓度为 (13 .2± 4 .0 ) μg·ml-1,曲线下面积为 (86.5± 2 1.1) μg·ml-1·h ,消除半衰期为 (13 .0± 6.2 )h。 4只家兔高尔夫练习球内的莫西沙星血清峰浓度 ,在为 3 .6± 2 .1μg·ml-12 4h内的平均曲线下面积为 (65 .4± 2 1.1) μg·ml-1·h。结论 :获得的莫西沙星在家兔模型中的药动学参数 ,对今后莫西沙星的药效学研究有很大的帮助。 | 钟明康 Xuan D Nicolau DP Nightingale CH2 | 2001 | 中国医院药学杂志2001，21，1： | 10 |
| 3 | Organic matter produced by algae and cyanobacteria: Quantitative and qualitative characterization显示文摘This work aims at characterizing organic matter produced by an alga Euglena gracilis and a cyanobacteria Microcystis aeruginosa and assessing the evolution of its characteristics during growth.A culture medium was optimized.The species growth phases were monitored using both visible spectrophotometry and flow cytometry cell counting.Organic matter fractionation according to hydrophobicity and specific UV absorbance(SUVA) index were used to specifically characterize the produced algal organic matter(AOM).The AOM characteristics were both growth phase and species dependent.However,a similar evolution was observed.The hydrophilic fraction(HPI) was the major fraction whatever the growth phases and was almost the only one produced during lag and exponential phases.It represented around 75% of AOM during exponential phase and then decreased when the stationary phase appeared.It represented 46% and 60% of the AOM during late decline phase for the cyanobacteria and the alga respectively.The hydrophobic(HPO) and transphilic(TPH) fractions started to appear from the beginning of the stationary phase with more hydrophobic compounds coming from intracellular organic material of dying cells.HPO and TPH percentages still increased during the decline phase probably because of two additional processes:photo-dissolution and leaching of particulate organic matter from cells fragments.A comparison of AOM during late decline phase and natural organic matter(NOM) from Glane River(France) underlined that AOM was more hydrophilic and presented a lower SUVA for each fractions than NOM.However,the difference between NOM and AOM hydrophobicity narrowed during decline phase. | Maud Leloup Rudy Nicolau Virginie Pallier Claude Yprmian Geneviève Feuillade-Cathalifaud | 2013 | Journal of Environmental Sciences2013，25，6： | 10 |
| 4 | Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T显示文摘AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE. | Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis Janio Szklaruk | 2016 | World Journal of Radiology2016，8，7： | 9 |
| 5 | 根据天气类型划分欧洲中期天气预报中心的集合预报产品显示文摘该研究的主要目的是找出一种对集合预报产品进行释用的新方法。其基本假定是集合预报要素在一定程度上代表了未来可能发生的天气形势。为了解决天气尺度在中期预报的不可预报性问题 ,引入了天气类型的概念。对集合预报进行划分的方法是 Diday提出的动力模糊法 ,初始划分时的重心由天气类型定义 ,划分用到的距离是位移和最大相关方法。根据城市块 (City- Block)距离找出了影响中国的按冬夏两季划分的天气类型 ,初步划分结果表明 ,欧洲中期天气预报中心的集合预报系统可以预报出横槽转竖型天气类型的演变情况 ,在夏天的预报效果则没有冬天好。 | 杨学胜 Jean Nicolau Nicole Girardot | 2001 | 气象学报2001，59，2： | 6 |
| 6 | 南极冬季威德尔海冰脊的表面形态显示文摘基于2006年南极威德尔海冬季科学考察期间由机载激光测高仪测得的海冰上表面高度数据,以脊高和脊距的理论与实测概率密度的相对误差之和为性能指标,以切断高度为控制变量建立优化模型。结果表明,W'80型分布和对数正态分布分别与实测脊高和脊距分布吻合较好;最优切断高度为0.62 m。进而从海冰表面起伏中确定出冰脊。利用k均值聚类算法以冰脊强度(Ri)为标准将剖面分为3类(Ri≤0.01,0.010.026)。对应各类剖面分别有:平均脊高为0.99 m,1.12 m和1.17 m;平均脊距为232 m,54 m和31 m。利用数学模型估算并分析了多脊冰平均厚度、有效厚度,帆横截面积及冰脊所占面积,这些参数值均随冰脊强度增大而增大。 | 谭冰 李志军 卢鹏 HASS Christian NICOLAUS Marcel | 2012 | 水科学进展2012，23，1： | 5 |
| 7 | 南极威德尔海冬季冰脊形拖曳力显示文摘利用2006年南极威德尔海冬季科学考察期间由机载激光高度计测得的海冰上表面形态数据,以拖曳分割理论为基础研究了冰脊形拖曳力及其对冰-气总拖曳力的贡献以及中性条件下对应10 m高度处风速的冰-气拖曳系数Cdn(10)。结果显示,在密集冰区,冰脊形拖曳力及其对总拖曳力的贡献随冰脊强度(脊高/脊距)的增大呈递增趋势,而随粗糙长度的增大而减小,对应于威德尔海冬季典型冰脊强度和粗糙长度,占总拖曳力的35%,说明了冰脊形拖曳力在冰-气界面动量交换中的重要作用。Cdn(10)随冰脊强度的增大而增大,但冰脊强度较小时,Cdn(10)随粗糙长度增大而增大;而对较大的冰脊强度,Cdn(10)则随粗糙长度增大而减小。 | 谭冰 卢鹏 李志军 HAAS Christian NICOLAUS Marcel | 2012 | 水科学进展2012，23，6： | 5 |
| 8 | Analysis on the crystals of sea ice cores derived from Weddell Sea,Antarctica显示文摘In order to understand the sea ice types and its region of origin frozen in Weddell Sea,27 ice cores were taken from Weddell Sea,Antarctica during September and October,2006.Their crystals were analyzed,and their ice forming processes were evaluated based on the crystals.Photos of the thin sections from two whole ice cores,and from polygonal granular superimposed ice were taken as well as corresponding stratigraphy descriptions.Vertical profiles of salinity, density and grain size were also obtained.Based on ice core structural texture,the findings include that: 1) although large and smooth ice floes were selected as the investigation sites, the ice sheet at the sampling position may be formed by rafted ice,consolidated ice ridges and second-year ice which were affected by dynamic and thermodynamic processes together subsequently.Ice formed in pure thermal growth comprises minority.The polygonal granular superimposed ice from refrozen wetted dense snow is one type of the ice in Antarctica.2) Of the all 27 ice cores,the granular,mixed granular-columnar and columnar crystals in sea ice occupy 28.7%,14.4% and 55.2%,respectively.3) The pure thermal growth ice is predominant in marginal sea ice zone;the rafted ice and consolidated ice ridges,even second-year ice and polygonal granular superimposed ice from dynamic and thermal effects were found in front of Larsen A Ice Shelf;the thermal growth ice froze in the polynyas of Larsen A,and was transferred outwards. | 李志军 Nicolaus Marcel Toyota Takenobu Haas Christian | 2010 | Chinese Journal of Polar Science2010，21，1： | 4 |
| 9 | Observation and modelling of snow and sea ice mass balance and its sensitivity to atmospheric forcing during spring and summer 2007 in the Central Arctic显示文摘Snow depth and sea ice thickness were observed applying an ice mass balance buoy(IMB)in the drifting ice station Tara during the International Polar Year in 2007.Detailed in situ observations on meteorological variables and surface fluxes were taken during May to August.For this study,the operational analyses and short-term forecasts from two numerical weather prediction(NWP)models(ECMWF and HIRLAM)were extracted for the Tara drift trajectory.We compared the IMB,meteorological and surface flux observations against the NWP products,also applying a one-dimensional thermodynamic sea ice model(HIGHTSI)to calculate the snow and ice mass balance and its sensitivity to atmospheric forcing.The modelled snow depth time series,controlled by NWP-based precipitation,was in line with the observed one.HIGHTSI reproduced well the snowmelt onset,the progress of the melt,and the first date of snow-free conditions.HIGHTSI performed well also in the late August freezing season.Challenges remain to model the“false bottom”observed during the melting season.The evolution of the vertical temperature profiles in snow and ice was better simulated when the model was forced by in situ observations instead of NWP results.During the melting period,the nonlinear ice temperature profile was successfully modelled with both forcing options.During spring and the melting season,total sea ice mass balance was most sensitive to uncertainties in NWP results for the downward longwave radiation,followed by the downward shortwave radiation,air temperature,and wind speed. | Bin CHENG Timo VIHMA Timo PALO Marcel NICOLAUS Sebastian GERLAND Laura RONTU Jari HAAPALA Donald PEROVICH | 2021 | Advances in Polar Science2021，32，4： | 4 |
| 10 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 11 | Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: Patterns of failure显示文摘 | Nicolaus Andratschke Frank Zimmermann Eva Boehm Sabine Schill Christine Schoenknecht Reinhard Thamm Michael Molls Carsten Nieder Hans Geinitz | 2011 | Radiotherapy and Oncology2011，，2： | 3 |
| 12 | Nicotinic cholinergic receptors in esophagus:Early alteration during carcinogenesis and prognostic value显示文摘AIM: To compare expression of nicotinic cholinergic receptors(CHRNs) in healthy and squamous cell carcinoma-affected esophagus and determine the prognostic value.METHODS: We performed RT-q PCR to measure the expression of CHRNs in 44 esophageal samples from healthy individuals and in matched normal surrounding mucosa, and in tumors from 28 patientsdiagnosed with esophageal squamous cell carcinoma(ESCC). Next, we performed correlation analysis for the detected expression of these receptors with the habits and clinico-pathological characteristics of all study participants. In order to investigate the possible correlations between the expression of the different CHRN subunits in both healthy esophagus and tissues from ESCC patients, correlation matrices were generated. Subsequently, we evaluated whether the detected alterations in expression of the various CHRNs could precede histopathological modifications during the esophageal carcinogenic processes by using receiver operating characteristic curve analysis. Finally, we evaluated the impact of CHRNA5 and CHRNA7 expression on overall survival by using multivariate analysis.RESULTS: CHRNA3, CHRNA5, CHRNA7 and CHRNB4, but not CHRNA1, CHRNA4, CHRNA9 or CHRNA10, were found to be expressed in normal(healthy) esophageal mucosa. In ESCC, CHRNA5 and CHRNA7 were overexpressed as compared with patient-matched surrounding non-tumor mucosa(ESCC-adjacent mucosa; P < 0.0001 and P = 0.0091, respectively). Positive correlations were observed between CHRNA3 and CHRNB4 expression in all samples analyzed. Additionally, CHRNB4 was found to be differentially expressed in the healthy esophagus and the normalappearing ESCC-adjacent mucosa, allowing for distinguishment between these tissues with a sensitivity of 75.86% and a specificity of 78.95%(P = 0.0002). Finally, CHRNA5 expression was identified as an independent prognostic factor in ESCC; patients with high CHRNA5 expression showed an increased overall survival, in comparison with those with low expression. The corresponding age- and tumor stage-adjusted hazard ratio was 0.2684(95%CI: 0.075-0.97, P = 0.0448).CONCLUSION: Expression of CHRNs is homogeneous along healthy esophagus and deregulated in ESCC, suggesting a pathogenic role for these receptors in ESCC development and progression. | Marina Chianello Nicolau Luis Felipe Ribeiro Pinto Pedro Nicolau-Neto Paulo Roberto Alves de Pinho Ana Rossini Tatiana de Almeida Simao Sheila Coelho Soares Lima | 2016 | World Journal of Gastroenterology2016，22，31： | 2 |
| 13 | Nutrient-hormone relations:Driving root plasticity in plants显示文摘Optimal plant development requires root uptake of 14 essential mineral elements from the soil.Since the bioavailability of these nutrients underlies large variation in space and time,plants must dynamically adjust their root architecture to optimize nutrient access and acquisition.The information on external nutrient availability and whole-plant demand is translated into cellular signals that often involve phytohormones as intermediates to trigger a systemic or locally restricted developmental response.Timing and extent of such local root responses depend on the overall nutritional status of the plant that is transmitted from shoots to roots in the form of phytohormones or other systemic long-distance signals.The integration of these systemic and local signals then determines cell division or elongation rates in primary and lateral roots,the initiation,emergence,or elongation of lateral roots,as well as the formation of root hairs.Here,we review the cascades of nutrient-related sensing and signaling events that involve hormones and highlight nutrient-hormone relations that coordinate root developmental plasticity in plants. | Zhongtao Jia Ricardo F.H.Giehl Nicolaus von Wirén | 2022 | Molecular Plant2022，15，1： | 2 |
| 14 | Ticagrelor Effects on Myocardial Infarction and the Impact of Event Adjudication in the Platelet Inhibition and Patient Outcomes (PLATO) Trial显示文摘 | Kenneth W. Mahaffey Claes Held Daniel M. Wojdyla Stefan K. James Hugo A. Katus Steen Husted Philippe Gabriel Steg Christopher P. Cannon Richard C. Becker Robert F. Storey Nardev S. Khurmi José C. Nicolau Cheuk-Man Yu Diego Ardissino Andrzej Budaj Joao Mor | 2014 | Journal of the American College of Cardiology2014，，： | 2 |
| 15 | Plasticiser effect of oleic acid polyester on polyethylene and polypropylene显示文摘 | Marcela Mantese Sander Aline Nicolau Rafael Guzatto Dimitrios Samios | 2012 | Polymer Testing2012，，8： | 2 |
| 16 | 南极威德尔海海冰晶体类型分析显示文摘为了解南极威德尔海不同区域海冰形成过程,分析了2006年9—10月威德尔海海冰调查中的27支冰芯晶体并描述了冰芯反映的冰层形成过程;给出2支完整冰芯晶体照片和多边形晶体雪冰照片,以及对应照片的冰层描述和冰盐度、密度、粒径。根据冰芯晶体揭示的海冰形成过程,发现尽管现场考察均选择较大表面平整的浮冰作业,但冰芯晶体揭示出实际冰层可以是受动力和热力联合作用形成的重叠冰、固结冰脊、二年冰;而从表面到底面属于纯热力学生长形成的冰层所占比例较小。积雪经过密实和水分参与,再冻结形成多边形晶体雪冰也是南极海冰主要组成之一。粒状晶体、过渡区混合晶体和柱状晶体海冰分别占27支冰芯总长度的28.7%、14.4%和55.2%。海冰的区域分布表现出海冰边缘区以纯热力学生长的一年冰为主;在冰架前缘,受动力作用形成的重叠冰和固结冰脊的比例增加,并且存在二年冰和多边形晶体雪冰;冰间湖内生长有大面积纯热力学生长的海冰并向外输送。 | 李志军 Nicolaus Marcel Toyota Takenobu Haas Christian | 2009 | 极地研究2009，21，3： | 2 |
| 17 | Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana显示文摘Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with:(i) inhibition of primary root growth under nitrogen limitation or on ammonium;(ii) rapid progression of lateral root emergence in response to ammonium; and(iii) inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies. | Takao Araya Takuya Kubo Nicolaus von Wiren Hideki Takahashi | 2016 | Journal of Integrative Plant Biology2016，58，3： | 2 |
| 18 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 2 |
| 19 | Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range:Great Potential for Solid-state Cooling显示文摘Solid-state cooling based on caloric effects is considered a viable alternative to replace the conventional vapor-compression refrigeration systems.Regarding barocaloric materials,recent results show that elastomers are promising candidates for cooling applications around room-temperature.In the present paper,we report supergiant barocaloric effects observed in acetoxy silicone rubber—a very popular,low-cost and environmentally friendly elastomer.Huge values of adiabatic temperature change and reversible isothermal entropy change were obtained upon moderate applied pressures and relatively low strains.These huge barocaloric changes are associated both to the polymer chain rearrangements induced by confined compression and to the first-order structural transition.The results are comparable to the best barocaloric materials reported so far,opening encouraging prospects for the application of elastomers in near future solid-state cooling devices. | William Imamura Erik Oda Usuda Lucas Soares Paixao Nicolau Molina Bom Angelo Marcio Gomes Alexandre Magnus Gomes Carvalho | 2020 | Chinese Journal of Polymer Science2020，38，9： | 2 |
| 20 | Abdominal sonographic study of autosomal dominant polycystic kidney disease显示文摘 | Nicolau C Torra R Bianchi L | 2000 | J Clin Ultrasound2000，28，6： | 2 |
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