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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Synthesis and physieoehemical characterization of anionic surfaetants derived from cashew nut shell oil显示文摘 | SCORZZA C NIEVES J FRANCIA V | 2009 | Journal of Surfactants and Detergents2009，13，1： | 1 |
| 3 | Biological properties of on- ions and garlic显示文摘 | iMarta C M Nieves C Mar V | 2007 | Trends in Food Science & Technology2007，18，12： | 1 |
| 4 | 显示文摘 | Reynoso C R Mora O Nieves V | 2004 | Animal Feed Science and Technology2004，113，： | 1 |
| 5 | Physiological and morphological responses to flooding with fresh or saline water in Jatropha curcas显示文摘 | Gimeno V Syvertsen J P Simón I Nieves M DíazLópez L Martínez V Garcia-Sanchez F | | 0，，： | 1 |
| 6 | S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replica- tion by NK cells显示文摘 | Arnold V Cummings J S Moreno Nieves U Y | 2013 | Retrovirology2013，10，： | 1 |
| 7 | Biological properties of onions and garlic 显示文摘 | Marta CM Nieves C Mar V | 2007 | Trends in Food Science and Technology2007，18，： | 1 |
| 8 | A comparative study of the ion composition of precipitation in two industrialized cities in Cantabria (Spain) 显示文摘 | Aurelia B Eugenio V Nieves D C | 1988 | Environment International1988，14，3： | 1 |
| 9 | Cryopreservation of chestnut by vitrification of in vitro-grown shoot tips显示文摘 | Nieves V Conchi S Lorena J | 2005 | In Vitro Cellular & Developmental Biology-Plant2005，41，1： | 1 |
| 10 | An evaluation of mineralanalysis of ' Vema' Lemons by DRIS 显示文摘 | Cerdd A Nieves M Marttnez V | 1995 | Communications in Soil Science and Plant Analysis1995，26，1112： | 1 |
| 11 | An evaluation of mineral analysis of 'Verna' Lemons by DRIS显示文摘 | Cerda A Nieves M Martinez V | 1995 | Common Soil Sci Plant Anal1995，26，1112： | 1 |
| 12 | Individual trabecula segmentation(ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements显示文摘 | Liu XS Stein EM Zhou B Zhang CA Nickolas TL Cohen A Thomas V McMahon DJ Cosman F Nieves J Shane E Guo XE | | 0，，： | 1 |
| 13 | Additional nitrogen fertili- zation affects salt tolerance of lemon trees on different rootstocks显示文摘 | Gimeno V Syvertsen J P Nieves M | 2009 | Scientia Horticulturae2009，121，3： | 1 |
| 14 | Optimization of conditions for galactooligosaccharide synthesis during lactose hydrolysis by β-galactosidase from Kluyveromyces lactis ( Lactozym 3000 L HP G) 显示文摘 | Cristina M V Alejandra C C Nieves C | 2008 | Food Chemistry2008，107，： | 1 |
| 15 | Additional nitrogen fer- tilization affects salt tolerance of lemon trees on different rootstocks 显示文摘 | GIMENO V SYVERTSEN J P NIEVES M | 2009 | Seientia Horticulturae2009，121，3： | 1 |
| 16 | The recombinant Omp31from brucella melitensis alone or associated with rongh lipopolysaccharide induce protection against Brueella ovis infection in Balb/c mice显示文摘 | Slivia M Juhana C Nieves V | 2003 | Microbes and infection2003，1，： | 1 |
| 17 | Cellular and molecular mechanisms of metformin : an overview显示文摘 | Benoit V Bruno G Nieves S | 2012 | Clin Sci2012，122，6： | 1 |
| 18 | Cellular and molecular mechanisms of metformin: an overview 显示文摘 | Benoit V Bruno G Nieves S | 2012 | Clin Sci2012，122，6： | 1 |
| 19 | Major outer membrane proteins of Brucella spp:past,present and future显示文摘 | Axel C Nieves V Jean Y P | 2002 | Veterinary Microbiology2002，90，： | 1 |
| 20 | Synthesis and physico- chemical characterization of anionic surfactants derived from cashew nut shell oil显示文摘 | Scorzza C Nieves J Francia V | 2010 | Journal Surfactants and Detergents2010，13，1： | 1 |
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