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| 1 | Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes显示文摘Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery. | Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 13 |
| 2 | Respiratory mechanics in brain injury: A review显示文摘Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients(BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case that non lung protective ventilator settings are applied. Measurement of respiratory mechanics in BD patients, as well as assessment of their evolution during mechanical ventilation, may lead to preclinical lung injury detection early enough, allowing thus the selection of the appropriate ventilator settings to avoid ventilatorinduced lung injury. The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients. | Antonia Koutsoukou Maria Katsiari Stylianos E Orfanos Anastasia Kotanidou Maria Daganou Magdalini Kyriakopoulou Nikolaos G Koulouris Nikoletta Rovina | 2016 | World Journal of Critical Care Medicine2016，5，1： | 7 |
| 3 | Chylorrhea complicating D2+a gastrectomy: review of the literature and clarification of terminology apropos one case显示文摘 | John Griniatsos Nikoletta Dimitriou Despina Kyriaki Antigoni Velidaki Stavros Sougioultzis Paris Pappas | 2010 | Chinese Medical Journal2010，，16： | 4 |
| 4 | Retroperitoneal perivascular epithelioid cell tumours: A case report and review of literature显示文摘BACKGROUND The perivascular epithelioid cell tumour(PEComa)family of tumours mainly includes renal and hepatic angiomyolipomas,pulmonary lymphangioleiomyomatosis and clear cell“sugar”tumour of the lung.Several uncommon tumours with similar morphological and immunophenotypical characteristics arising at a variety of sites(abdominal cavity,digestive tract,retroperitoneum,skin,soft tissue and bones)are also included in the PEComa family and are referred to as PEComas not otherwise specified.CASE SUMMARY We present a 37-year-old female patient who underwent resection of an 8.5 cm×8 cm×4 cm retroperitoneal tumour,which eventually was diagnosed as PEComa of uncertain biological behaviour.Three years after the operation,the patient remains without any evidence of recurrence.A search was performed in the Medline and EMBASE databases for articles published between 1996 and 2018,and we identified 31 articles related to retroperitoneal and perinephric PEComas.We focused on sex,age,maximum dimension,histological and immunohistochemical characteristics of the tumour,follow-up and long-term outcome.Thirty-four retroperitoneal(including the present one)and ten perinephric PEComas were identified,carrying a malignant potential rate of 44%and 60%,respectively.Nearly half of the potentially malignant PEComas presented with or developed metastases during the course of the disease.CONCLUSION Retroperitoneal PEComas are not as indolent as they are supposed to be.Radical surgical resection constitutes the treatment of choice for localized disease,while mammalian target of the rapamycin(mTOR)inhibitors constitute the most promising therapy for disseminated disease.The role of mTOR inhibitors as adjuvant or neoadjuvant therapies needs to be evaluated in the future. | Zisis Touloumis Niki Giannakou Christos Sioros Argiro Trigka Maria Cheilakea Nikoletta Dimitriou John Griniatsos | 2019 | World Journal of Clinical Cases2019，7，21： | 4 |
| 5 | Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer显示文摘AIM:To evaluate routine modified D2 lymphadenectomy in gastric cancer,based on immunohistochemically detected skip micrometastases in levelⅡlymph nodes. METHODS:Among 95 gastric cancer patients who were routinely submitted to curative modified D2 lymphadenectomy,from January 2004 to December 2008,32 were classified as pN0.All levelⅠlymph nodes of these 32 patients were submitted to immunohistochemistry for micrometastases detection. Patients in whom micrometastases were detected in the levelⅠlymph node stations(n=4)were excluded from further analysis.The levelⅡlymph nodes of the remaining 28 patients were studied immunohistochemically for micrometastases detection and constitute the material of the present study. RESULTS:Skip micrometastases in the levelⅡlymph nodes were detected in 14%(4 out of 28)of the patients. The incidence was further increased to 17%(4 out of24)in the subgroup of T1-2 gastric cancer patients.All micrometastases were detected in the No.7 lymph node station.Thus,the disease was upstaged from stageⅠA toⅠB in one patient and from stageⅠB toⅡin three patients. CONCLUSION:In gastric cancer,true R0 resection may not be achieved without modified D2 lymphadenectomy. Until D2+/D3 lymphadenectomy becomes standard, modified D2 lymphadenectomy should be performed routinely. | John Griniatsos Hara Gakiopoulou Eugenia Yiannakopoulou Nikoletta Dimitriou Gerasimos Douridas Afrodite Nonni Theodoros Liakakos Evangelos Felekouras | 2009 | World Journal of Gastroenterology2009，15，44： | 3 |
| 6 | Complete mesocolic excision: Techniques and outcomes显示文摘Complete mesocolic excision(CME) for the treatment of colon cancer was first introduced in the West in 2008. The first aim of this procedure is to remove the afflicted colon and its accessory lymphovascular supply by resecting the colon and mesocolon in an intact envelope of visceral peritoneum, which holds potentiallyinvolved lymph nodes. The second component of CME is a central vascular tie to remove completely all lymph nodes in the central(vertical) direction. In its original iteration, CME was performed via laparotomy, although many centers preferentially perform laparoscopic surgery, with its associated benefits and similar oncolo-gical outcomes, as the standard treatment for colonic cancer. Here, we present the surgical techniques for CME in open and laparoscopic surgery, as well as the surgical, pathological and oncological outcomes of the procedure that are available to date. Because there are no randomized control trials comparing CME to 'standard' colon surgery, the principles underlying CME seem anatomical and logical, and the results published from the Far East, reporting an 80% 5-year survival rate for Stage III cancer, should guide us. | Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 7 | Lymph node,peritoneal and bone marrow micrometastases in gastric cancer:Their clinical significance显示文摘The 7th TNM classification clearly states that micro-metastases detected by morphological techniques(HE stain and immunohistochemistry) should always be reported and calculated in the staging of the disease(pN1mi or M1),while patients in whom micrometas-tases are detected by non-morphological techniques(e.g.,ow cytometry,reverse-transcriptase polymerase chain reaction) should still be classif ied as N0 or M0.In gastric cancer patients,micrometastases have been de-tected in lymph nodes,the peritoneal cavity and bone marrow.However,the clinical implications and/or their prognostic signif icance are still a matter of debate.Cur-rent literature suggests that lymph node micrometasta-ses should be encountered for the loco-regional staging of the disease,while skip lymph node micrometastases should also be encountered in the total number of infiltrated lymph nodes.Peritoneal fluid cytology ex-amination should be obligatorily performed in pT3 or pT4 tumors.A positive cytology classif ies gastric cancer patients as stage Ⅳ.Although a curative resection is not precluded,these patients face an overall dismal prognosis.Whether patients with a positive cytology should be treated similarly to patients with macroscopic peritoneal recurrence should be evaluated further.Gas-tric cancer cells are detected with high incidence in the bone marrow.However,the published results make comparison of data between groups almost impossible due to severe methodological problems.If these meth-odological problems are overcome in the future,specif ic target therapies may be designed for specif ic groups of patients. | John Griniatsos Othon Michail Nikoletta Dimitriou Ioannis Karavokyros | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 1 |
| 8 | VEGF and IL-18 in induced sputum of lung cancer patients 显示文摘 | Nikoletta Rovina Georgios Hillas Efressini Dima ct al | 2011 | Cyto- kine2011，54，： | 1 |
| 9 | Dissipation of the Fungicide Tetraconazole from Field-sprayed Sugar Beets显示文摘 | MENKISSOGLU-SPIROUDI U XANTHOPOULOU NIKOLETTA J IOANNIDIS PHILIPPOS M | 1998 | Agric Food Chem1998，46，： | 1 |
| 10 | Treatment of pituitary tumors显示文摘 | Gabriella Iván Nikoletta Szigeti-Csúcs Márk Oláh Cy?rgy M. Nagy Miklós I. Góth | 2005 | Endocrine2005，，1： | 1 |
| 11 | A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease显示文摘 | Nakou Alexandra Papaparaskevas Joseph Diamantea Filia Skarmoutsou Nikoletta Polychronopoulos Vlasis Tsakris Athanassios | 2014 | Future Microbiology2014，，11： | 1 |
| 12 | Role of montmorillonite in flame retardancy of ethylene-vlnyl acetate copolymer显示文摘 | Andrea Sze'p Andra's Szabo' Nikoletta To'th | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 13 | Development of a non-labeled immunosensor for the herbicide trifluralin via optical waveguide lightmode spectroscopic detection显示文摘 | ANDRS S NIKOLETTA T NRA A | 2006 | Analytica Chimica Acta2006，487，1： | 1 |
| 14 | Octreotide versus hydrocortisone versus placebo in the prevention of post-ERCP pancreatitis: A multicenter randomized controlled trial显示文摘 | Spilios Manolakopoulos Alec Avgerinos John Vlachogiannakos Anastasios Armonis Nicolaos Viazis Nicholas Papadimitriou Nikoletta Mathou Gerasimos Stefanidis George Rekoumis Eleni Vienna Dimitrios Tzourmakliotis Sotirios A. Raptis | 2002 | Gastrointestinal Endoscopy2002，，4： | 1 |
| 15 | Accurate quantitative analysis of gold alloys using multi-pulse laser induced breakdown spectroscopy and a correlation-based calibration method显示文摘 | Gabor G Nikoletta J Gabor C | 2008 | Spectrochimica Acta2008，63，5： | 1 |
| 16 | Predictive mod- els for oral drug absorption: from in silico methods to integrated dynamical models 显示文摘 | Aristides D Lida K Nikoletta F | 2007 | Expert Opin Drug Metab Toxicol2007，3，4： | 1 |
| 17 | Role of montmorillonite in flame retardancy of ethyleneevinyl acetate copolymer 显示文摘 | Andrea Sze'p Andra's Szabo' Nikoletta To'th | 2006 | Polymer Degradation and Stability2006，91，3： | 1 |
| 18 | Assessment of my- ocardial perfusion and viability by Positron Emission Tomography 显示文摘 | Constantinos A Alexandros G Nikoletta P | 2013 | Int J Cardiol2013，167，5： | 1 |
| 19 | Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells显示文摘 | Kempuraj D Nikoletta G Lytinas M | 2004 | Endocrinology2004，145，1： | 1 |
| 20 | Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice显示文摘 | Nikoletta Rovina | 2010 | 2010 (defa)2010，，： | 1 |
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