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| 1 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 2 | Long‐term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis显示文摘 | Jiannis Vlachogiannakos Nikos Viazis Panagiota Vasianopoulou Irene Vafiadis Dimitrios G Karamanolis Spiros D Ladas | 2013 | J Gastroenterol Hepatol2013，，3： | 4 |
| 3 | Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches 显示文摘 | Heidi K Hugo G Niko M | 2006 | Experim Cell Res2006，319，6： | 1 |
| 4 | Compatibility of poly (vinyl chloride ) with epoxidized copolymers of butadiene-styrene 显示文摘 | Antonis G Margaritis John K Kallitsis Nikos K Kalfoglou | 1989 | Polymer1989，30，12： | 1 |
| 5 | Transformation and normalvector calculation of parametrically defined surfacesbased on dual vectors and screw theory : Application toPhong's shading model 显示文摘 | Stavros G P Nikos A A | 2006 | Computer Graphics Forum2006，25，2： | 1 |
| 6 | Antif~ngal Activity of Lemongrass (Cympopogon Citratus L) Essential Oil against Key Posthar- vest Pathogens显示文摘 | NIKOS G T COSTAS D E | 2007 | Innovative Food Science and Emerging Technologies2007，，5： | 1 |
| 7 | Uncertainty and the se- mantic Web 显示文摘 | Stoilos G Nikos S Stamou G | 2006 | IEEE Trans on Intelligent Systems2006，21，5： | 1 |
| 8 | Analgesia and an-esthesia for assisted reproductive technologies显示文摘 | Nikos FV Iosifina G Athanasios V | 2009 | Int J Gy-necol Obstes2009，105，3： | 1 |
| 9 | Elastic-plastic response spectra for exponential blast loading显示文摘 | Charis J G Nikos G P | 2004 | International Journal of Impact Engineering2004，30，3： | 1 |
| 10 | Spatioteporal variation of a Pinus seed rain avaiable for an endemic finch in an insular envi- ronment显示文摘 | Eduardo G R Nikos N Unai L H | 2011 | Journal of Ecology2011，57，： | 1 |
| 11 | 查看详情显示文摘 | Niko Y Kawauchi S Otsu S Tokumaru K Konishi G | | 0，，： | 1 |
| 12 | Calcium Carbonate Phase Analysis using XRD and RE-Raman Spectroscopy 显示文摘 | Christos G Konto Y Nikos V V | 2000 | Analyst2000，125，： | 1 |
| 13 | 显示文摘 | Minhee Lee Niko G Gubernator | 2010 | J Am Chem Soc2010，132，： | 1 |
| 14 | Disease and community structure : the importance of host self-regulation in a host-hostpathogen model 显示文摘 | Begon M Bowers R G Nikos K | 1992 | Am Nat1992，139，6： | 1 |
| 15 | The Transformation ofVaterite to Calcite: Effect of the Conditions of the Solutions in Contact with the Mineral Phase显示文摘 | Nikos S Petros G K | 1998 | Journal of Crystal Growth1998，191，： | 1 |
| 16 | Dense image registration through MRFs and efficient linear programming显示文摘 | BEN G NIKOS K GEORGIOS T | 2008 | Medical Image Analysis2008，12，6： | 1 |
| 17 | Uncertainty and the semantic Web 显示文摘 | Stoilos G Nikos S Stamou G | 2006 | IEEE Trans on Intelligent Systems2006，21，5： | 1 |
| 18 | Magnetic properties of co-modified Fe,N-Ti O2nanocomposites显示文摘 | Grzegorz Z Spiros G Niko G | 2015 | Open Physics2015，13，1： | 1 |
| 19 | The ovarian hyper stimula-tion Syndrome显示文摘 | Joseph G Vhelan Ⅲ Nikos F | 2000 | Fertilsteril2000，73，5： | 1 |
| 20 | The Transformation of Vaterite to Calcite:Effect of the Conditions of the Solutions in Contact with the Mineral Phase显示文摘 | Nikos S Petros G K | 1998 | Journal of Crystal Growth1998，191，4： | 1 |
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