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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Molecular overview of progressive familial intrahepatic cholestasis显示文摘Cholestasis is a clinical condition resulting from the imapairment of bile flow.This condition could be caused by defects of the hepatocytes,which are responsible for the complex process of bile formation and secretion,and/or caused by defects in the secretory machinery of cholangiocytes.Several mutations and pathways that lead to cholestasis have been described.Progressive familial intrahepatic cholestasis(PFIC)is a group of rare diseases caused by autosomal recessive mutations in the genes that encode proteins expressed mainly in the apical membrane of the hepatocytes.PFIC 1,also known as Byler’s disease,is caused by mutations of the ATP8B1 gene,which encodes the familial intrahepatic cholestasis 1 protein.PFIC 2 is characterized by the downregulation or absence of functional bile salt export pump(BSEP)expression via variations in the ABCB11 gene.Mutations of the ABCB4 gene result in lower expression of the multidrug resistance class 3 glycoprotein,leading to the third type of PFIC.Newer variations of this disease have been described.Loss of function of the tight junction protein 2 protein results in PFIC 4,while mutations of the NR1H4 gene,which encodes farnesoid X receptor,an important transcription factor for bile formation,cause PFIC 5.A recently described type of PFIC is associated with a mutation in the MYO5B gene,important for the trafficking of BSEP and hepatocyte membrane polarization.In this review,we provide a brief overview of the molecular mechanisms and clinical features associated with each type of PFIC based on peer reviewed journals published between 1993 and 2020. | Sriram Amirneni Nils Haep Mohammad A Gad Alejandro Soto-Gutierrez James E Squires Rodrigo MFlorentino | 2020 | World Journal of Gastroenterology2020，26，47： | 17 |
| 3 | Two-year outcomes of ab interno trabeculectomy with the Trabectome for Chinese primary open angle glaucoma: a retrospective multicenter study显示文摘AIM: To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open angle glaucoma(POAG) patients.METHODS: This was a multicenter, retrospective, observational study and included POAG patients with or without visually-significant cataracts. The Chinese patients were enrolled from three glaucoma centers and a group of comparable Japanese POAG patients was analyzed from our international Trabectome database. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome was intraocular pressure(IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2 y. Success was defined as: 1) IOP≤21 mm Hg and at least 20% IOP reduction from baseline after 3 mo at any two consecutive visits; 2) no additional glaucoma surgery required.RESULTS: A total of 42 Chinese POAG patients from three glaucoma centers were enrolled. Twelve patients underwent Trabectome surgery combined with phacoemulsification and intraocular lens implantation while the remainder underwent Trabectome surgery alone. Thirteen patients had a history of failed glaucoma surgery and were considered as complicated cases. In China data, the mean preoperative IOP was 21.4±1.23 mm Hg. The Trabectome lowered IOP to 17.9±1.8 mm Hg at 2 y(P=0.05). The number of glaucoma medications also decreased significantly from a baseline of 2.0±0.9 to 1.1±0.8 at 2 y post-surgery(P=0.04). The overall 2-year success rate was 78%, with patients undergoing combined surgery having a higher success rate compared with those undergoing Trabectome surgery alone(100% vs 76%). In Japan data, the mean preoperative IOP was 20.8±7.7 mm Hg. The Trabectome lowered IOP to 12.20±2.0 mm Hg at 2 y. The number of glaucoma medications also decreased significantly from a baseline of 2.1±0.9 to 3.4±0.6 at 2 y post-surgery. In all patients, no major complications were seen.CONCLUSION: Surgery with the Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the long-term. | Ya-Long Dang Xiao Wang Wan-Wei Dai Ping Huang Nils A Loewen Chun Zhang 无 | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 5 |
| 4 | Management of syndesmotic injuries:What is the evidence?显示文摘Ankle fractures are accompanied by a syndesmotic injury in about 10% of operatively treated ankle fractures. Usually, the total rupture of the syndesmotic ligaments with an external rotation force is associated with a Weber type B or C fracture or a Maisonneuve fracture. The clinical assessment should consist of a comprehensive history including mechanism of injury followed by a specific physical examination. Radiographs, and if in doubt magnetic resonance imaging, are needed to ascertain the syndesmotic injury. In the case of operative treatment the method of fixation, the height and number of screws and the need for hardware removal are still under discussion. Furthermore, intraoperative assessment of the accuracy of reduction of the fibula in the incisura using fluoroscopy is difficult. A possible solution might be the assessment with intraoperative three-dimensional imaging. The aim of this article is to provide a current concepts review of the clinical presentation, diagnosis and treatment of syndesmotic injuries. | Marc Schnetzke Sven Y Vetter Nils Beisemann Benedict Swartman Paul A Grützner Jochen Franke | 2016 | World Journal of Orthopedics2016，7，11： | 4 |
| 5 | Viral RNAi suppressor reversibly binds siRNA to outcompete dicer and RISC via multiple turnover 显示文摘 | Renata A R Vishalakshi K Nils G W | 2011 | J Mol Biol2011，408，2： | 1 |
| 6 | Device Driver and DMA Controller Synthesis from HW/ SW Communication Protocol Specifications显示文摘 | O’Nils M Jantseh A | 2001 | Design Automation for Embedded Systems2001，6，2： | 1 |
| 7 | A simple and convenient microtiter plate assay for the detection of bactericidal antibodies to Vibrio cholerae O1 and Vibrio cholerae O139显示文摘 | Boutonnier A Dassy B Duménil R | 2003 | J Microbiol Methods2003，55，3： | 1 |
| 8 | The role of germacrene D as a precursor in sesquiterpene biosynthesis: investigations of acid catalyzed, photochemically and thermally induced rearrangements显示文摘 | Nils Bulow Wilfried A Konig | 2000 | Phytochemistry2000，55，： | 1 |
| 9 | Ultrasonic assess- ment of the melting behaviour in fat from Iberian dry - cured hams显示文摘 | Nil OLES L MULET A VENTANAS S | 2010 | Meat Science2010，85，： | 1 |
| 10 | Responses of photosynthetic efficincy, cell shape and motility in Euglena gracilis (Euglenophyceae) to short-term exponsure to heavy metals and pentachlorophenol显示文摘 | Roman A D Nils G A | 2001 | Water Air and Soil Pollution2001，132，： | 1 |
| 11 | Techniques and outcomes of minimally invasive trabecular ablation and bypass surgery 显示文摘 | KAPLOWITZ KEVIN SCHUMAN JOEL S LOEWEN NILS A | 2014 | Br J Ophthalmol2014，98，5： | 1 |
| 12 | Monte Carlo filters for non-linear state estimation显示文摘 | ERIK B PETER J A NILS C | 2001 | Automatica2001，37，： | 1 |
| 13 | Critical evaluation of the Global TODS Expansion Plane显示文摘 | Donald A Enarson Nils E Billo | 2007 | Bulletin of the World Health Organization2007，85，5： | 1 |
| 14 | Assessing theeffectiveness of a large database of emotion-eliciting films: Anew tool for emotion researchers 显示文摘 | Schaefer A Nils F Sanchez X | 2010 | Cognition andEmotion2010，24，7： | 1 |
| 15 | Five -year functional outcome analysis of ankle fracture fixation 显示文摘 | Shah Nil Sundaram RO Velusamy A | 2007 | Injury2007，38，11： | 1 |
| 16 | Synthesis and Photodynamic Potential of Tetra- and octa-trieth- ylencoxysalfonyl Substituted Zinc Phthalocyanines显示文摘 | Devrim A Nil S Mahmut D | 2007 | Journal of Photochemistry and Photobiology A: Chemistry( S 1010-6030)2007，186，： | 1 |
| 17 | Enhanced bioavailability of piroxicam using Gelucire 44/14 and Labrasol: in vitro and in vivo evaluation显示文摘 | Nilüfer Yüksel Aysegül Karata? Yal??n ?zkan Ayhan Sava?er Sibel A ?zkan Tamer Baykara | 2003 | European Journal of Pharmaceutics and Biopharmaceutics2003，，3： | 1 |
| 18 | Genetic and EcologicalConsequences of Transgene Flow to the Wild Flora显示文摘 | Fran?ois F Gregor K Nils A | 2007 | AdvBiochem Engin/Biotechnol2007，，107： | 1 |
| 19 | Natice and oxidiged LDL enhances production of PDGH AA and the surface expression of PDGF receptors in cultured human smooth muscle cells显示文摘 | Stiko- Rahm A Hultgardh- Nil' son A Regnestom J | 2002 | Arterioscler Thromb2002，12，： | 1 |
| 20 | Biodegradable fixation of rabbit osteotomies显示文摘 | Torbjorm A Nils D Lundberg A | 1994 | Acta Orthop Scand1994，65，2： | 1 |
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