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| 1 | Should multi-gene panel testing replace limited BRCA1/2 testing? A review of genetic testing for hereditary breast and ovarian cancers显示文摘Clinical testing of patients for hereditary breast and ovarian cancer syndromes began in the mid-1990s with the identification of the BRCA1 and BRCA2 genes.Since then,mutations in dozens of other genes have been correlated to increased breast,ovarian,and other cancer risk.The following decades of data collection and patient advocacy allowed for improvements in medical,legal,social,and ethical advances in genetic testing.Technological advances have made it possible to sequence multiple genes at once in a panel to give patients a more thorough evaluation of their personal cancer risk.Panel testing increases the detection of mutations that lead to increased risk of breast,ovarian,and other cancers and can better guide individualized screening measures compared to limited BRCA testing alone.At the same time,multi-gene panel testing is more time-and cost-efficient.While the clinical application of panel testing is in its infancy,many problems arise such as lack of guidelines for management of newly identified gene mutations,high rates of variants of uncertain significance,and limited ability to screen for some cancers.Through on-going concerted efforts of pooled data collection and analysis,it is likely that the benefits of multi-gene panel testing will outweigh the risks in the near future. | Nimmi S Kapoor Kimberly C Banks | 2016 | World Journal of Surgical Procedures2016，6，1： | 2 |
| 2 | Panoramic radiological study to identify locally displaced maxillary canines in Bangladeshi population显示文摘 | Alif SM Haque S Nimmi N | 2011 | Imaging Sci Dent2011，41，4： | 1 |
| 3 | Do begin thyroid nodules have malignant potential,an evidence-based review显示文摘 | NIMMI ARORA THERESA SCOGAMIGLIO BAIXIN ZHU | 2008 | World J Surg2008，32，7： | 1 |
| 4 | The Chemokine Receptors CXCR4 and CCR7 are Associated with Tumor Size and Pathologic Indicators of Tumor Aggressiveness in Papillary Thyroid Carcinoma显示文摘 | Patrick L. Wagner MD Tracy-Ann Moo MD Nimmi Arora MD Yi-Fang Liu MD Rasa Zarnegar MD Theresa Scognamiglio MD Thomas J. Fahey MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 5 | Inhibition of Vibrio cholerae biofilm by AiiA enzyme produced from Bacillus spp.显示文摘 | Nimmy Augustine Praveen Kumar Sabu Thomas | 2010 | Archives of Microbiology2010，，12： | 1 |
| 6 | Cyclic loading on the red cello membrane in a shear flow: a possible cause of hemolysis显示文摘 | Nimmi H Sugihara M | 1985 | J Biomeeh Eng1985，107，： | 1 |
| 7 | Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer 显示文摘 | Nimmi A Diana M Danielle R | 2008 | Am J Surg2008，196，4： | 1 |
| 8 | Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer显示文摘 | Nimmi Arora Diana Martins Danielle Ruggerio Eleni Tousimis Alexander J. Swistel Michael P. Osborne Rache M. Simmons | 2008 | The American Journal of Surgery2008，，4： | 1 |
| 9 | Next generation sequencing under de novo genome assembly显示文摘 | Sonia Farhana Nimmy M. S. Kamal | 2015 | International Journal of Biomathematics2015，8，5： | 1 |
| 10 | Validation of Foreground Emission Model using GALEX Medium Observations显示文摘The study of diffuse ultraviolet(UV)background radiation is vital in the investigation of stellar and galactic evolution.Space-based UV observations are comprised of both foreground and background radiations.The foreground emission in an observation is a result of solar contamination in the direction of observation.In our previous work,we modeled airglow(one of the major constituents of the foreground emission)as a function of10.7 cm Solar Flux and Sun Angle with great accuracy using GALEX deep observations.We adopt a similar methodology to validate the obtained model and run equivalent experiments here using far-UV(FUV)and nearUV(NUV)GALEX medium imaging surveys(MIS)with a total exposure time greater than 3300 s.We obtained a predictive model having excellent compatibility with the earlier model.Our analysis shows that the total foreground emission varies between 59 and 295 photon units in FUV whereas in NUV,it varies between 671 and1195 photon units depending upon the date and time of observation.We also noticed a strong correlation between the background emission and optical depth both in FUV and NUV,especially in the low density regions.This clearly indicates that the major contributor in diffuse background radiation is the starlight scattered by interstellar dust grains. | Nimmi Narayanan Shivashankar S.Menon N.V.Sujatha | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 0 |
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