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| 1 | Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor显示文摘AIM: To explore the expression and correlation of CD44v6,vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and matrix metalloproteinase (MMP)-9 in Krukenberg and primary epithelial ovarian carcinoma.METHODS: The expressions of CD44v6, VEGF, MMP-2and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma.RESULTS: The expression of CD44v6 (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue:x2= 4.516, P= 0.034; Krukenberg tumor tissue vsnormal ovarian tissue: x2 = 19.537, P= 0.001) and VEGF (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue: P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue: x2= 22.895, P = 0.001) was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue.The positive expression rate of MMP-2 and MMP-9 was 0%in the normal ovarian tissue. The positive expression rate of CD44v6 (x2 = 10.398, P = 0.001), VEGF (x2 = 13.149,P= 0.001), MMP-2 (x2= 33.668, P= 0.001) and MMP-9(x2= 38.839, P = 0.001) was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor.CONCLUSION: CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor. | Ge Lou Ying Gao Xiao-Ming Ning Qi-Fan Zhang | 2005 | World Journal of Gastroenterology2005，11，32： | 20 |
| 2 | Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins显示文摘我们分析了 20 化学感应的蛋白质(CSP ) 蚕 Bombyx mori 的基因。我们发现了在 introns 插入的 retrotransposons 的一个高数字。我们然后用量的即时聚合酶链反应(PCR ) 越过纸巾分析了 20 BmorCSP 基因的表示。BmorCSPs 的相对低的表示层次在内脏和胖身体纸巾被发现。我们因此在 BmorCSP 基因表示上测试了 endectocyte 杀虫药剂 abamectin (B1a 和 B1b avermectins ) 的效果。量的即时 PCR 实验证明到杀虫药剂 abamectin 的单个简短暴露戏剧性地不仅在天线而且在大多数纸巾增加了 CSP 表示,包括内脏和胖身体。而且,我们的学习响应杀虫药剂以一种织物依赖者方式显示出 CSP 和新陈代谢的细胞色素 P450 酶的并列表示。CSP 的功能仍然保持未知。基于我们的结果,我们在检测然后被细胞色素 P450 anti-xenobiotic 酶除去的 xenobiotics 建议一个角色。 | Ning Xuan Xia Guo Hong-Yan Xie Qi-Nian Lou Xing-Bo Lu Guo-Xia Liu Jean-Francois Picimbon | 2015 | Insect Science2015，22，2： | 18 |
| 3 | The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease显示文摘From the global outbreak of SARS-CoV caused infection disease in 2003,coronaviruses(CoVs)are known to be a great threat to the human health.Recently,a new SARS-like coronavirus,human betacoronavirus 2c EMC/2012(HCoV-EMC),has been identified and the appearance of this new CoV raises concerns that a new spread of CoV may occurs in the future.By solving the crystal structure of HCoV-EMC main protease with a wide-spectrum anti-CoV inhibitor N3,we confi rmed that that N3 blocks the function of HCoV-EMC main protease through a similar mechanism to other CoVs.Together with the good pharmaceutical features,N3 is conceivable to be effective to HCoV-EMC and other CoVs appearing in the future.These fi ndings make it convincing that CoVs will not be a threat to human health. | Zhilin Ren Liming Yan Ning Zhang Yu Guo Cheng Yang Zhiyong Lou Zihe Rao | 2013 | Protein & Cell2013，4，4： | 10 |
| 4 | Necroptosis in inflammatory bowel disease and other intestinal diseases显示文摘For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease(IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD. | Sha Li Long-Gui Ning Xin-He Lou Guo-Qiang Xu | 2018 | World Journal of Clinical Cases2018，6，14： | 7 |
| 5 | Joint Approximate Diagonalization Using Bilateral Rank-Reducing Householder Transform with Application in Blind Source Separation显示文摘 | ZHANG Weitao LIU Ning LOU Shuntian | 2009 | Chinese Journal of Electronics2009，18，3： | 7 |
| 6 | Intermediate-depth earthquakes beneath the Pamir-Hindu Kush Region:Evidence for collision between two opposite subduction zones显示文摘We employed a double-difference algorithm(hypoDD)to relocate earthquakes within the region bounded by 66°E-78°E and 32°N-42°N in the period of 1964?2003 reported by the International Seismological Center(ISC).The improved hypocentral locations delineate a double-layered Wadati-Benioff zone in the eastern Hindu Kush intermediate seismic belt.Based on this feature and other evidences,we propose that the intermediate-depth earthquakes beneath the Pamir-Hindu Kush region may occur in two collided subduction zones with opposite dip directions. | Xiaoting Lou Chen Cai Chunquan Yu Jieyuan Ning | 2009 | Earthquake Science2009，22，6： | 6 |
| 7 | Elimination of misrun and gas hole defects of investment casting TiAl alloy turbocharger based on numerical simulation and experimental study显示文摘Casting technology of thin-wall TiAl alloy turbochargers was studied by investment casting and numerical simulation.Misruns and gas holes were the main defects observed in preliminary work due to the poor fluidity of alloy,and to gas entrapment.In order to eliminate these defects,cast parameters,such as centrifugal rotation rate and mould preheating temperature,were optimized by numerical simulation,meanwhile,the structure of the shell mould was optimized to improve the filling capacity of TiAl alloy.Pouring experiments were carried out by vacuum induction melting furnace equipped with a water-cooled copper crucible based on the above optimization.The quality of the TiAl alloy casting was analyzed by fluorescent penetrant inspection and X-ray detection.The results show that a centrifugal rotation rate of 200 rpm,mould preheating temperature of 600°C,shell preparation through organic fiber addition can dramatically improve the mould filling capacity,and integrated turbochargers were finally prepared. | Jun Zhao Zhi-yong Zhang Shi-bing Liu Kun Shi Chun-ling Bao Zhao-sheng Ning Ping Yan Lei Wang Yan-chun Lou | 2020 | China Foundry2020，17，1： | 6 |
| 8 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 9 | Room-temperature chlorine gas sensor based on CdSnO_(3) synthesized by hydrothermal process显示文摘The perovskite-structure CdSnO_(3) was obtained by calcinating CdSnO_(3)·3H_(2)O precursor at 550℃,which was synthesized by hydrothermal process at 170℃for 16 h.The phase and microstructure of the obtained CdSnO_(3) powders were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The CdSnO_(3) powders exhibit uniformly cubic structure with side length of about 100 nm.The effects of working temperature and concentration of detected gas on the gas response were studied.The selectivity of chlorine gas against other gases and response-recovery time of the sensor were also investigated.The results reveal that the CdSnO_(3) gas sensor has enhanced sensing properties to 1-10 ppm chlorine gas at room temperature;the value of gas response can reach 1338.9 to 5 ppm chlorine gas.Moreover,the sensor shows good selectivity and quick response behavior(23 s)to chlorine gas,indicating its application in detecting chlorine gas at room temperature in the future. | Xiaohua ZHAO Zhenzhen LI Xiangdong LOU Meng LI Ning ZHANG | 2013 | Journal of Advanced Ceramics2013，2，1： | 3 |
| 10 | Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China显示文摘Heat stroke is the most severe type of heat illness,it is often accompanied by severe multiorgan damage and has a high fatality rate.In January 2020,based on new research evidence and the experiences of Chinese experts in heat stroke,the Expert Group of Heat Stroke Prevention and Treatment of the Chinese People’s Liberation Army(PLA)and the Professional Committee of Critical Care Medicine of the Chinese PLA jointly issued a new Expert Consensus on the Diagnosis and Treatment of Heat Stroke in China.This article aims to interpret and supplement the major updates to the new consensus. | Shu-Yuan Liu Qian Wang Yun-Peng Lou Yan Gao Bo Ning Qing Song Hai-Ling Li | 2020 | Military Medical Research2020，7，3： | 3 |
| 11 | Effect of Coriolus Versicolor Polysaccharide-B on the Biological Characteristics of Human Esophageal Carcinoma Cell Line Eca109显示文摘Objective To investigate the effect of Coriolus versicolor polysaccharide-B(CVPs-B) on the biological characteristics of human esophageal carcinoma cell line Eca109 in vitro. Methods The cells of experimental group(EG) were cultured in DMEM with 10% FCS and 150μg/mL CVPs-B,the cells of control group(CG) were cultured in DMEM with 10% FCS without CVPs-B.MTT reduction assay was performed to detect the effect of CVPs-B on the proliferation of Eca109 cells after the compound was administrated in varying concentrations.The living conditions of the Eca109 cells were determined using trypan blue exclusion.Then,cell growth curves were drawn.Flow cytometry was performed to detect the effect of CVPs-B on the apoptosis and cell cycle of Eca109. Results In comparison with the CG,a marked decrease in the proliferation of Eca09 cells was observed in the EG,after incubation with CVPs-B.The survival rate of Eca09 cells decreased as the time of CVPs-B incubation prolonged.Comparing the cell cycles and apoptotic rates between the two groups,the proportions of cells in the G0/G1,S,and G2/M phases in the EG were found to be(68.4±3.7)% ,(13.9±2.1)% ,and(17.7±1.4)% ,respectively,after 24 h incubation with CVPs-B.The cells had an apoptotic rate of (9.7±0.7)% .On the other hand,the proportions of the G0/G1,S,and G2/M cells of the CG were found to be(53.9±3.6)% ,(26.6±2.8)% ,and (19.5±2.3)% ,respectively,with an apoptotic rate of(5.7±1.4)% .In comparison with the CG cells,significant cell growth in the G0/G1 phase was observed in the EG(P<0.05).Furthermore,a significant decrease in the number of cells in the S phase was observed(P<0.05) in the EG. Conclusions CVPs-B can inhibit proliferation and enhance apoptosis of Eca109 cells and may be useful in the treatment of esophageal carcinoma. | Dao-feng Wang Ning Lou Xiao-dong Li | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 3 |
| 12 | Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice显示文摘Intracytoplasmic sperm injection (ICSI) is commonly used to solve male infertility problems. Previous studies showed that early environmental exposure of an embryo may influence postnatal development. To detect whether ICSI operations affect the reproductive health of a male or his offspring, we established assisted reproductive technologies (ART) conceived mouse models, and analyzed gene expression profiles in the testes of both ICSI and naturally conceived (NC) newborn F1 mice using micro-array analysis. Among the differentially expressed genes, we focused on the expression of eight male reproduction-related genes. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to analyze the expression of these genes in the testes of both adult and old F1 generation mice and adult F2 generation mice. Our results showed that down-regulated and somatic cell-expressed genes in newborn mice retained their differential expression patterns in adult and old F1 generation individuals, implying the persistence and fetal origin of the alteration in the expression of these genes. The intergenerational transmission of differential gene expression was observed, but most changes tended to be reduced in adult F2 generations. Controlled ovarian hyperstimulation (COH) and in vitro fertilization (IVF) mice models were added to explore the precise factors contributing to the differences in ICSI offspring. The data demonstrated that superovulation, in vitro culture, and mechanical stimulation involved in ICSI had a cumulative effect on the differential expression of these male reproductive genes. | Li-ya WANG Ning WANG Fang LE Lei LI Le-jun LI Xiao-zhen LIU Ying-ming ZHENG Hang-ying LOU Xiang-rong XU Xiao-ming ZHU Yi-min ZHU He-feng HUANG Fan JIN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，5： | 2 |
| 13 | Excellent photothermal conversion of core/shell CdSe/ Bi2Se3 quantum dots显示文摘分散水的 CdSe/Bi < 潜水艇 class= “ a-plus-plus ” > 2 Se < 潜水艇 class= “ a-plus-plus ” > 有 27.09% 的一个 photothermal 变换系数的 3 核心 / 壳 QD 被阳离子交换反应综合了。QD 的微观结构和水晶结构,被 TEM 和 XRD 证实,证明部分阳离子交换发生在 CdSe QD 内。二主要机制为优秀 photothermal 变换负责:搬运人的放射的再结合的抑制由于 type-II 半导体 heterostructures,和 QD 的大 surface-to-volume 比率的形成。Photothermal 变换实验显示 CdSe/Bi < 潜水艇 class= “ a-plus-plus ” > 2 Se < 潜水艇 class= “ a-plus-plus ” > 3 QD 显示出高 photothermal 变换效率和优秀 NIR photostability。 | Guo Zhi Jia Wen Kai Lou Fang Cheng Xiong Long Wang Jiang Hong Yao Ning Dai Hai Qing Lin Kai Chang | 2015 | Nano Research2015，8，5： | 2 |
| 14 | Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM ‐induced autophagy or BAX显示文摘 | Kai Liu Jinli Lou Tao Wen Jiming Yin Bin Xu Wei Ding Anna Wang Daojie Liu Chao Zhang Dexi Chen Ning Li | 2013 | Liver Int2013，，10： | 1 |
| 15 | Analysis of phases in a Cu-Cr-Zr alloy 显示文摘 | HUANG Fu-xiang MA Ju-sheng NING Hong-long GENG Zhi-ting LU Chao GUO Shu-mei YO Xue-tao WANG Tao LI Hong LOU Hua-fen | 2003 | Scr Mater2003，48，1： | 1 |
| 16 | An improved method for isolation of microvascular endothelial cells from normal and inflamed human lung显示文摘 | Jin Ning Lou Nabil Mili Christine Decrind Yves Donati Sylvie Kossodo Anastase Spiliopoulos Bara Ricou Peter M. Suter Denis R. Morel Philippe Morel Georges E. Grau | 1998 | In Vitro Cellular & Developmental Biology - Animal1998，，7： | 1 |
| 17 | Microbial transformation of diosgenin by Syncephalastrum racemosum(Cohn) Schroeter显示文摘Microbial transformation of diosgenin(1) by Syncephalastrum racemosum yielded five new polar metabolites,which wereidentified as(25R)-spirost-5-en-3β,7α,9α-triol-12-one(2),(25R)-spirost-5-en-3β,9α,12α-triol-7-one(3),(25R)-spirost-5-en-3β,9α-diol-7,12-dione(4),(25R)-spirost-4-en-9α,12β,14α-triol-3-one(5),and(25S)-spirost-4-en-9α,14α,25β-triol-3-one(6).Compounds 1-6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2,3,and 6 were more potentthan the parent compound 1. | Zhao, Ying Sun, Ling Mei Wang, Xiao Ning Shen, Tao Ji, Mei Li, Xia Lou, Hong Xiang | 2010 | Chinese Chemical Letters2010，21，1： | 1 |
| 18 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 19 | 疤痕子宫产前出血可能是子宫动脉瘤的潜在危险信号(英文)显示文摘目的:子宫动脉瘤多被认为与产程中创伤性操作相关,但近年陆续有报道显示子宫动脉瘤可发生于自然分娩过程中。本文将为自然分娩过程中子宫动脉瘤的发生和紧急处理等提供参考指导。创新点:产前出血可能是子宫动脉瘤发生的潜在危险信号。方法:病例报道和文献汇纳分析。患者女,37岁,疤痕子宫,临产入院,产前出血,经阴顺产后12 h,突发阴道大量出血,常规对症处理(按摩子宫、阴道填塞、缩宫素静滴和欣母佩宫颈注射等)未能有效缓解,40 min内出血达1800 ml。床边B超未提示动脉瘤特征,数字减影血管造影(DSA)显示左侧子宫动脉瘤,即刻予动脉栓塞成功止血。患者产后4 d无并发症出院,随访无后遗症。结论:临床医师需要加强对子宫动脉瘤发生的警惕认识和急救处理水平。子宫动脉瘤和产程中的有创性操作无必然相关性,疤痕子宫的产前出血可能是子宫动脉瘤发生的潜在危险信号,产后随访应提高对晚期出血发生的警惕性。鉴于B超在诊断动脉瘤方面的有限性,高度怀疑动脉瘤时应尽快行血管造影明确诊断,及时栓塞处理。 | Ning ZHANG Wei-hua LOU Xue-bin ZHANG Jian-hua LIN Wen DI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，5： | 1 |
| 20 | Analysis of phases in a Cu-Cr-Zr alloy显示文摘 | HUANG F X MA J S NING H L GENG Z T LU C GUO SM YU X T WANG T LI H LOU H F | | 0，，： | 1 |
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