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| 1 | The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease显示文摘From the global outbreak of SARS-CoV caused infection disease in 2003,coronaviruses(CoVs)are known to be a great threat to the human health.Recently,a new SARS-like coronavirus,human betacoronavirus 2c EMC/2012(HCoV-EMC),has been identified and the appearance of this new CoV raises concerns that a new spread of CoV may occurs in the future.By solving the crystal structure of HCoV-EMC main protease with a wide-spectrum anti-CoV inhibitor N3,we confi rmed that that N3 blocks the function of HCoV-EMC main protease through a similar mechanism to other CoVs.Together with the good pharmaceutical features,N3 is conceivable to be effective to HCoV-EMC and other CoVs appearing in the future.These fi ndings make it convincing that CoVs will not be a threat to human health. | Zhilin Ren Liming Yan Ning Zhang Yu Guo Cheng Yang Zhiyong Lou Zihe Rao | 2013 | Protein & Cell2013，4，4： | 10 |
| 2 | FDTD for plasmonics:Applications in enhanced Raman spectroscopy显示文摘The exact electromagnetic enhancement mechanism behind SERS,TERS,HERS and SHINERS is one of the issues focused on in the study of enhanced Raman spectroscopy.The three dimensional finite difference time domain method(3D-FDTD),which is widely used in nanoplasmonic simulations,not only provides us with a powerful numerical tool for theoretical studies of the ERS electromagnetic enhancement mechanism,but also serves as a useful tool for the design of ERS-active systems with higher sensitivities and spectral spatial resolution.In this paper,we first introduce the fundamental principles of FDTD algorithms,and then the size-dependent dielectric function of dispersive metallic material is discussed.A comparative study of FDTD and rigorous Mie evaluations of electromagnetic fields in the vicinity of a system of self-similar nanospheres shows an excellent correlation between the two computational methods,directly confirming the validity and accuracy of 3D-FDTD simulations in ERS calculations.Finally,we demonstrate,using a TERS calculation as an example,that the non-uniform mesh method can be more computationally efficient without loss of accuracy if it is applied correctly. | YANG ZhiLin LI QianHong RUAN FangXiong LI ZhiPeng REN Bin XU HongXing TIAN ZhongQun | 2010 | Chinese Science Bulletin2010，55，24： | 6 |
| 3 | Photoinduced large polaron transport and dynamics in organic-inorganic hybrid lead halide perovskite with terahertz probes显示文摘Organic-inorganic hybrid metal halide perovskites(MHPs)have attracted tremendous attention for optoelectronic applications.The long photocarrier lifetime and moderate carrier mobility have been proposed as results of the large polaron formation in MHPs.However,it is challenging to measure the effective mass and carrier scattering parameters of the photogenerated large polarons in the ultrafast carrier recombination dynamics.Here,we show,in a one-step spectroscopic method,that the optical-pump and terahertz-electromagnetic probe(OPTP)technique allows us to access the nature of interplay of photoexcited unbound charge carriers and optical phonons in polycrystalline CH_(3)NH_(3)PbI_(3)(MAPbI_(3))of about 10μm grain size.Firstly,we demonstrate a direct spectral evidence of the large polarons in polycrystalline MAPbI_(3).Using the Drude-Smith-Lorentz model along with the Frӧhlich-type electron-phonon(e-ph)coupling,we determine the effective mass and scattering parameters of photogenerated polaronic carriers.We discover that the resulting moderate polaronic carrier mobility is mainly influenced by the enhanced carrier scattering,rather than the polaron mass enhancement.While,the formation of large polarons in MAPbI_(3)polycrystalline grains results in a long charge carrier lifetime at room temperature.Our results provide crucial information about the photo-physics of MAPbI3 and are indispensable for optoelectronic device development with better performance. | Zuanming Jin Yan Peng Yuqing Fang Zhijiang Ye Zhiyuan Fan Zhilin Liu Xichang Bao Heng Gao Wei Ren Jing Wu Guohong Ma Qianli Chen Chao Zhang Alexey VBalakin Alexander PShkurinov Yiming Zhu Songlin Zhuang | 2022 | Light(Science & Applications)2022，11，8： | 4 |
| 4 | SERS mechanism of nickel electrode显示文摘Based on the theoretical model for the two-dimensional arrays, the dependence of the surface-enhanced Raman scattering (SERS) effect of nickel electrode, especially the ordered two-dimensional nanowires, on the incident photon energy in the range of 0.6-4.0 eV are analyzed, and most of the works are focused on the effect of the shape of nano-particles. The theoretical analysis shows that nickel can exhibit weak surface-enhanced Raman scattering effect when the surface is roughened properly, and the enhancement factor is about 102-104. Compared to the typical highly SERS-active Ag substrate, the SERS of nickel does not show the character of surface plasma resonance of the metal. The calculated result shows that the lightning-rod effect contributes the most to the SERS of Ni nanowires in the EM mechanism. The theoretical prediction is in good agreement with the experimental result qualitatively and may be instructive to finding a new method to fabricate the SERS-active transition-metal substrate. | YANG Zhilin WU Deyin YAO Jianlin HU Jianqiang REN Bin ZHOU Haiguang TIAN Zhongqun | 2002 | Chinese Science Bulletin2002，47，23： | 2 |
| 5 | Near-field coupling and SERS effects of palladium nanoparticle dimers显示文摘The linear optical properties and the surface-enhanced Raman scattering (SERS) effect of spherical palladium nanoparticle dimers are analyzed theoretically using generalized Mie theory. The calculation results demonstrate that the near-field coupling effect greatly influences the absorption, scattering and extinction spectra of nanoparticle dimers. The surface plasmon resonance wave- length red-shifts dramatically as the separation between nanoparticles decreases. Because of the near-field coupling between nanoparticles and the size effect, the maximum SERS enhancement factor at the 'hot spot' between palladium nanoparticle dimers is as high as 107-108, while the averaged SERS enhancement factor over the entire nanoparticle surface is in the range of 105-106. The deviation between the position of the peak in the extinction spectrum and the wavelength for maximum surface-averaged enhancement for the Pd nanoparticle dimers indicates that localized surface plasmon resonance has different influences on the far and near fields. These theoretical results may help to reveal the relationship between the far and near fields, as well as understand the mechanism of electromagnetic enhancement in the surface-enhanced scattering of transition metals. | RUAN FangXiong ZHANG ShunPing LI ZhiPeng YANG ZhiLin WU DeYin REN Bin XU HongXing | 2010 | Chinese Science Bulletin2010，55，26： | 2 |
| 6 | Research of an SHPB Device in Two-by-Two Form for Impact Experiments of Concrete-Like Heterogeneous Materials显示文摘A split Hopkinson pressure bar(SHPB)device in two-by-two form,including the bar bundle form and the single cylindrical bar form,was designed in response to the demand for the dynamic mechanical experiments for brittle materials such as concrete,rock,etc.The stress waveforms generated through a projectile impacting two different types of incident bars have been studied based on the one-dimensional stress wave theory and numerical simulation method.At last,based on the established two types of mesoscale concrete models with random convex polyhedral aggregates,we performed comparison analysis of SHPB numerical simulations for concrete materials with bar bundle and single cylindrical bar separately,so as to provide technical support for the manufacture and development of this experimental device.The results showed that the introduced two-by-two form SHPB device expanded the scope of practical application,and the wave dispersion effect existing in a large-diameter bar can be evidently reduced when we employed the bar bundle form,indicating its applicability to the dynamic mechanical experiments of concrete-like heterogeneous materials. | Ruiqi Guo Huiqi Ren Lei Zhang Zhilin Long Xiangyun Wu Hailu Wang | 2021 | Acta Mechanica Solida Sinica2021，34，4： | 2 |
| 7 | Treatment‐related adverse events of antibody‐drug conjugates in clinical trials:A systematic review and meta‐analysis显示文摘Background:The wide use of antibody‐drug conjugates(ADCs)is transforming the cancer‐treatment landscape.Understanding the treatment‐related adverse events(AEs)of ADCs is crucial for their clinical application.We conducted a meta‐analysis to analyze the profile and incidence of AEs related to ADC use in the treatment of solid tumors and hematological malignancies.Methods:We searched the PubMed,Embase,and Cochrane Library databases for articles published from January 2001 to October 2022.The overall profile and incidence of all‐grade and grade≥3 treatment‐related AEs were the primary outcomes of the analysis.Results:A total of 138 trials involving 15,473 patients were included in this study.The overall incidence of any‐grade treatment‐related AEs was 100.0%(95%confidence interval[CI]:99.9%–100.0%;I2=89%)and the incidence of grade≥3 treatment‐related AEs was 6.2%(95%CI:3.0%–12.4%;I2=99%).Conclusions:This study provides a comprehensive overview of AEs related to ADCs used for cancer treatment.ADC use resulted in a high incidence of any‐grade AEs but a low incidence of grade≥3 AEs.The AE profiles and incidence differed according to cancer type,ADC type,and ADC components. | Jinming Li Guoshuang Shen Zhen Liu Yaobang Liu Miaozhou Wang Fuxing Zhao Dengfeng Ren Qiqi Xie Zitao Li Zhilin Liu Yi Zhao Fei Ma Xinlan Liu Zhengbo Xu Jiuda Zhao | 2023 | Cancer Innovation2023，2，5： | 1 |
| 8 | Sonoelectrochemieal degra- dation of phenol in aqueous solutions 显示文摘 | Ren Yanze Wu Zhilin Franke M | 2013 | Ultrosonies Sonoehem- istry2013，20，2： | 1 |
| 9 | Risk analysis during departure and reception of shield in the Yellow River crossing tunnel of the middle route project of South-to-North Water Diversion 显示文摘 | DUN Zhilin CAO Yang REN Lianwei | 2011 | Applied Mechanics and Materials2011，9093，： | 1 |
| 10 | (Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5) high-entropy ceramic with low thermal conductivity,tunable thermal expansion coefficient,and excellent resistance to CMAS corrosion显示文摘Low thermal conductivity,compatible thermal expansion coefficient,and good calcium–magnesium–aluminosilicate(CMAS)corrosion resistance are critical requirements of environmental barrier coatings for silicon-based ceramics.Rare earth silicates have been recognized as one of the most promising environmental barrier coating candidates for good water vapor corrosion resistance.However,the relatively high thermal conductivity and high thermal expansion coefficient limit the practical application.Inspired by the high entropy effect,a novel rare earth monosilicate solid solution(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)was designed to improve the overall performance.The as-synthesized(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)shows very low thermal conductivity(1.07 W·m-1·K-1 at 600℃).Point defects including mass mismatch and oxygen vacancies mainly contribute to the good thermal insulation properties.The thermal expansion coefficient of(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)can be decreased to(4.0–5.9)×10^(-6)K^(-1)due to severe lattice distortion and chemical bonding variation,which matches well with that of SiC((4.5–5.5)×10^(-6)K^(-1)).In addition,(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)presents good resistance to CMAS corrosion.The improved performance of(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)highlights it as a promising environmental barrier coating candidate. | Zhilin CHEN Zhilin TIAN Liya ZHENG Keyu MING Xiaomin REN Jingyang WANG Bin LI | 2022 | Journal of Advanced Ceramics2022，11，8： | 1 |
| 11 | A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody显示文摘To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosup-pressive cancers like triple-negative breast cancer(TNBC),induction of immunogenic cell death(ICD)at tumor sites can increase the antigenicity and adjuvanticity to activate the immune microenvironment so that tumors become sensitive to the intervention of immune checkpoint inhibitors.Herein,a self-amplified biomimetic nanosystem,mEHGZ,was constructed by encapsulation of epirubicin(EPI),glucose oxidase(Gox)and hemin in ZIF-8 nanoparticles and coating of the nanoparticles with calreticulin(CRT)over-expressed tumor cell mem-brane.EPI acts as an ICD inducer,Gox and hemin medicate the cascade generation of reactive oxygen species(ROS)to strengthen the ICD effect,and CRT-rich membrane as“eat me”signal promote presentation of the released antigens by dendritic cells(DCs)to invoke the tumor-immunity cycle.The biomimetic delivery system displays an amplified ICD effect via Gox oxidation,hydroxyl radical generation and glutathione(GSH)depletion.The induced potent ICD effect promotes DCs maturation and cytotoxic T lymphocytes(CTLs)infiltration,reversing an immunosuppressive tumor microenvironment to an immunoresponsive one.Treatment with the nanosystem in combination with anti-PD-L1 antibody results in distinctive inhibition of tumor growth and lung metastasis,supporting that a potent ICD effect can significantly boost the therapeutic efficacy of the anti-PD-L1 antibody.This self-amplified biomimetic nanoplatform offers a promising means of raising the response rate of immune checkpoint inhibitors. | Zhilin Li Hao Cai Zhiqian Li Long Ren Xuelei Ma Hongyan Zhu Qiyong Gong Hu Zhang Zhongwei Gu Kui Luo | 2023 | Bioactive Materials2023，，3： | 1 |
| 12 | Boosting anapole-exciton strong coupling in all-dielectric heterostructures显示文摘The light manipulation beyond the diffraction limit plays an invaluable role in modern physics and nanophotonics.In this work,we have demonstrated a strong coupling with a large Rabi splitting of 151 me V between bulk WS_(2)excitons and anapole modes in the WS_(2)-Si nanodisk heterostructure array with nanoholes as small as 50 nm radius.This result is acquired by introducing anapole modes to suppress radiative losses to confine light into subwavelength volumes and large spatial overlapping between excitons and strong optical fields.Our work shows that anapole modes may serve as a powerful way to enhance the interaction between light and matter at nanoscales,and it should pave an avenue toward high-performance all-dielectric optoelectronic applications. | JINGYU WANG WEIMIN YANG GUOYA SUN YONGLIN HE PEIWEN REN ZHILIN YANG | 2022 | Photonics Research2022，10，7： | 0 |
| 13 | The Regulating Mechanism of Nm23-H1 Gene for FAK Signal Pathway in Human Lung Cancer Cell Line L9981显示文摘Background and objective Lung Cancer is one of the most malignant cancers threatening people’s health and life and one of the most rapid increasing cancers both in morbidity | Dejun KONG Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhi-hao WU Ke XU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 14 | Transfection of Nm23-H1 Gene Inhibited the Metastatic Potential of Human High-metastatic Large Cell Lung Cancer L9981显示文摘Background and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism of | Haixia ZHENG Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 15 | The Inhibiting Effects and It's Molecular Mecanisms of the Fungi of Huai Er's on Human Large Cell Lung Cancer Cell Line L9981显示文摘Background and Objective Lung cancer, which threatens human’s health and life, is the malignant tumor with the most rapid increase of morbidity. Although recent years the basic | Yu FAN Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 16 | Study on the Uncertainty of Earthquake Damage Prediction Based on Damage Indices for RC Structures显示文摘Seismic damage indices of structure are widely used to quantificationally analyze structural damage levels under earthquake action. In this paper, a five-storey building model and a seventeen-storey building model are established. According to seven typical indices and different earthquake-inputs, a structural damage prediction is performed, with the results showing serious uncertainty of structural damage prediction due to different indices. Understanding of this phenomenon aids the comprehension and application of the results of earthquake damage prediction. | Zhao Fengxin Ren Zhilin Zhang Yushan | 2009 | Earthquake Research in China2009，23，3： | 0 |
| 17 | Corrigendum to “A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody” [Bioact. Mater. 21 299-312]显示文摘The authors regret the incorrect publication of corresponding authors for the article.The corresponding authors have been updated as Hongyan Zhu(hyzhu_hmrrc@126.com)and Kui Luo(luokui@scu.edu.cn),and the same should be updated in the supplementary file as well. | Zhilin Li Hao Cai Zhiqian Li Long Ren Xuelei Ma Hongyan Zhu Qiyong Gong Hu Zhang Zhongwei Gu Kui Luo | 2023 | Bioactive Materials2023，，4： | 0 |
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