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| 1 | Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells显示文摘Metformin,为类型 II 糖尿病的第一线药,开始由于发现癌症减少的流行病的报告作为一个有希望的反癌症代理人进入了聚光灯在拿 metformin 的糖尿病的病人的风险和改进临床的结果。揭开 metformin 的反癌症机制,现出症状之前的潜的研究决定 metformin 损害细胞的新陈代谢并且压制表明小径,包括的受体酷氨酸 kinase, PI3K/Akt,和 mTOR 的 oncogenic 小径。最近, metformin 的反癌症潜力在癌症干细胞(CSC ) 上由于它的禁止的效果获得了增加的兴趣,它与肿瘤转移,药抵抗,和恶化被联系。用包括胸,各种各样的癌症模型的研究胰腺,前列腺,和结肠,通过指向涉及房间区别,更新,转移,和新陈代谢的特定的小径在 attenuating CSC 表明了 metformin 的力量。在这评论,我们提供反癌症行动的全面概述和 metformin 的机制,包括 CSC 和相关小径的规定。我们也作为单音讨论 metformin 的潜在的反癌症应用 -- 或联合治疗。 | Nipun Saini Xiaohe Yang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 19 |
| 2 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 3 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 4 | Safety and Efficacy of Low Anterior Resection for Rectal Cancer: 681 Consecutive Cases From a Specialty Service显示文摘 | Warren E. Enker Nipun Merchant Alfred M. Cohen Nicole M. Lanouette Carol Swallow Jose Guillem Philip Paty Bruce Minsky Katherine Weyrauch Stuart H. Q. Quan | 1999 | Annals of Surgery1999，，4： | 3 |
| 5 | A Multicenter Analysis of Distal Pancreatectomy for Adenocarcinoma: Is Laparoscopic Resection Appropriate?显示文摘 | David A. Kooby William G. Hawkins C. Max Schmidt Sharon M. Weber David J. Bentrem Theresa W. Gillespie Johnita Byrd Sellers Nipun B. Merchant Charles R. Scoggins Robert C.G. Martin Hong Jin Kim Syed Ahmad Clifford S. Cho Alexander A. Parikh Carrie K. Chu | 2010 | Journal of the American College of Surgeons2010，，5： | 2 |
| 6 | Endoscopic Ultrasound and Computed Tomography Predictors of Pancreatic Cancer Resectability显示文摘 | Philip Q. Bao J. Chad Johnson Elizabeth H. Lindsey David A. Schwartz Ron C. Arildsen Ewa Grzeszczak Alexander A. Parikh Nipun B. Merchant | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 7 | onunion of paediatric talar neck fracture显示文摘儿科学的距骨的破裂在治疗期间是由 posttraumatic 关节和 avascular 坏死很复杂的很少发生的损害。在孩子不属于工会以前没在文学被报导。我们报导有的一个 12 岁的男孩的一个案例一 talar 的霍金斯类型 II 骨折不属于工会颈。不属于工会与好临床的结果通过手术被对待。管理在的目标儿科学的 talar 颈骨折不属于工会与在新鲜破裂的那些不同。没有试试可以引起进一步的缺陷的一个激进的手术,非最优的减小应该是可接受的。 | Nipun Jindal Parmanand Gupta Sandeep Jindal | 2014 | Chinese Journal of Traumatology2014，17，1： | 2 |
| 8 | Left-sided Pancreatectomy: A Multicenter Comparison of Laparoscopic and Open Approaches显示文摘 | David A. Kooby Theresa Gillespie David Bentrem Attila Nakeeb Max c. Schmidt Nipun B. Merchant Alex A. Parikh Robert C. G. Martin Charles R. Scoggins Syed Ahmad Hong Jin Kim Jaemin Park Fabian Johnston Matthew J. Strouch Alex Menze Jennifer Rymer Rebecca M | 2008 | Annals of Surgery2008，，3： | 2 |
| 9 | Endoscopic Ultrasound and Computed Tomography Predictors of Pancreatic Cancer Resectability显示文摘 | Philip Q. Bao J. Chad Johnson Elizabeth H. Lindsey David A. Schwartz Ron C. Arildsen Ewa Grzeszczak Alexander A. Parikh Nipun B. Merchant | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 10 | A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods显示文摘 | Eric T.Castaldo T. MarkEarl Ravi S.Chari D.Gorden Nipun B.Merchant J. KellyWright Irene D.Feurer C. WrightPinson | 2009 | HPB2009，，5： | 1 |
| 11 | CXCL13–CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis显示文摘 | Subir Biswas Suman Sengupta Sougata Roy Chowdhury Samir Jana Gunjan Mandal Palash Kumar Mandal Nipun Saha Vivek Malhotra Arnab Gupta Dmitry V. Kuprash Arindam Bhattacharyya | 2014 | Breast Cancer Research and Treatment2014，，2： | 1 |
| 12 | Two-waycoupled SPH and particle level set fluid simulation 显示文摘 | Losasso F Jerry O T Nipun Kwatra | 2008 | IEEE Transactions on Visualization and ComputerGraphics (S1077-2626)2008，14，4： | 1 |
| 13 | A Model for Specification and Synchronization of Data for Distributed Multimedia Applications 显示文摘 | Nipun Agarwal Sang Son | 1996 | Journal of Multimedia Tools and Applications1996，3，2： | 1 |
| 14 | Wind integration in power systems: operational challenges and possible solutions显示文摘 | XIE Le LIU Ju-hua NIPUN P | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 15 | Enhanced delivery of baicalein using cinnamaldehydecross-linked chitosan nanoparticle inducing apoptosis显示文摘 | VARUKATTU NIPUN BABU SOUNDARAPANDIAN KANNAN | 2012 | Interna-tional Journal of Biological Macromolecules2012，，： | 1 |
| 16 | The role of calcitonin gene- relatedpeptide and nitric oxide in gastic mucosal hyperemia and protection显示文摘 | Nipun B Jay Goodman BS Daniel T | 1995 | J Sur Res1995，58，： | 1 |
| 17 | Vein Involvement During Pancreaticoduodenectomy: Is There a Need for Redefinition of “Borderline Resectable Disease”?显示文摘 | Kaitlyn J. Kelly Emily Winslow David Kooby Neha L. Lad Alexander A. Parikh Charles R. Scoggins Syed Ahmad Robert C. Martin Shishir K. Maithel H. J. Kim Nipun B. Merchant Clifford S. Cho Sharon M. Weber | 2013 | Journal of Gastrointestinal Surgery2013，，7： | 1 |
| 18 | Wind integration in power systems: operational challenges and possible solutions显示文摘 | XIE Le LIOE Ju-hua Nipun Popli | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 19 | RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention显示文摘 | Christopher J. Donnelly Ping-Wu Zhang Jacqueline T. Pham Aaron R. Haeusler Nipun A. Mistry Svetlana Vidensky Elizabeth L. Daley Erin M. Poth Benjamin Hoover Daniel M. Fines Nicholas Maragakis Pentti J. Tienari Leonard Petrucelli Bryan J. Traynor Jiou Wang | 2013 | Neuron2013，，2： | 1 |
| 20 | Texture optimization for example-based synthesis显示文摘 | Vivek Kwatra Irfan Essa Aaron Bobick Nipun Kwatra | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
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