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| 1 | Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer显示文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study. | Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata | 2010 | World Journal of Gastroenterology2010，16，10： | 14 |
| 2 | Formation of glycerol dehydrogenase by microorganisms显示文摘 | YAMADA H NAGAO A NISHISE H | 1982 | Agric Biol Chem1982，46，9： | 1 |
| 3 | Investigation of Musashi-1 Expressing Cells in the Murine Model of Dextran Sodium Sulfate-Induced Colitis显示文摘 | Tadahisa Fukui MD Hiroaki Takeda MD Hong-Jin Shu MD Katsuyoshi Ishihama MD Sayaka Otake MD Yasukuni Suzuki MD Shoichi Nishise MD Nanami Ito MD Takeshi Sato MD Hitoshi Togashi MD Sumio Kawata MD | 2006 | Digestive Diseases and Sciences2006，，7： | 1 |
| 4 | Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study显示文摘AIM To examine the relationship between pancreatic hyperechogenicity and risk factors for metabolic syndrome.METHODS A general population-based survey of lifestyle-related diseases was conducted from 2005 to 2006 in Japan. The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. The echogenicity of the pancreas and liver was compared, and then the subjects were separated into two groups: cases with pancreatic hyperechogenicity(n = 208) and cases without(controls, n = 264). The differences between both groups were compared using an unpaired t-test or Fisher's exact test. Multiple logistic regression analysis was used to determine the relationship between the pancreatic hyperechogenicity and clinical and bio-chemical parameters.RESULTS Subjects with pancreatic hyperechogenicity had decreased serum adiponectin concentration compared to control subjects [8.9(6.5, 12.8) vs 11.1(7.8, 15.9), P < 0.001] and more frequently exhibited features of metabolic syndrome. Logistic regression analysis showed that the following variables were significantly and independently associated with pancreatic hyperechogenicity: Presence of hypoadiponectinemia, increased body mass index(BMI), higher homeostasis model assessment of insulin resistance(HOMA-IR) score, and presence of fatty liver. Similar associations were also observed in subjects with pancreatic hyperechogenicity without fatty liver. Multivariate association analysis of data from participants without fatty liver showed that hypoadiponectinemia was significantly associated with pancreatic hyperechogenicity(OR = 0.93, 95%CI: 0.90- 0.97, P < 0.001). This association was independent of other confounding variables. Additionally, an increased BMI and higher HOMA-IR score were significantly associated with pancreatic hyperechogenicity.CONCLUSION Pancreatic hyperechogenicity is independently associated with increased BMI, insulin resistance, and hypoadiponectinemia in the general population. | Naohiko Makino Nakao Shirahata Teiichiro Honda Yoshiaki Ando Akiko Matsuda Yushi Ikeda Miho Ito Yuko Nishise Takafumi Saito Yoshiyuki Ueno Sumio Kawata | 2016 | World Journal of Hepatology2016，8，33： | 1 |
| 5 | Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis显示文摘 | Takafumi Saito Masahiro Sugimoto Kaori Igarashi Kaori Saito Li Shao Tomohiro Katsumi Kyoko Tomita Chikako Sato Kazuo Okumoto Yuko Nishise Hisayoshi Watanabe Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga | 2013 | Metabolism2013，，11： | 1 |
| 6 | Formation of glycerol dehydrogenase by microorganisms显示文摘 | Yamada H Nagao A Nishise H | 1982 | Agricultural and Biological Chemistry1982，46，9： | 1 |
| 7 | 显示文摘 | Nishise H | 1999 | Journal of Biotechnology1999，75，23： | 1 |
| 8 | Formation of glycerol dehydrogenase by microorganisms 显示文摘 | Yamada H Nagao A Nishise H Tani Y | 1982 | Agricultural and Biological Chemistry1982，46，9： | 1 |
| 9 | Formation of glycerol dehydrogenase by microorganisms 显示文摘 | Yamada H Nagao A Nishise H | 1982 | Agric Biol Chem1982，46，9： | 1 |
| 10 | Preventive effect of Lactobacillus delbrueckii subsp, blgaricus on the oxidation of LDL显示文摘 | TERAHARA M NISHISE S KANEKO T | 2002 | Biosci Biotechnol Biochem2002，64，9： | 1 |
| 11 | GOX373显示文摘 | Kimiyasu Isobe and Hiroshi Nishise A method for glyoxylic acid production using cells of Alcaligenes sp | 1999 | Journal of Biotechnology1999，75，： | 1 |
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