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| 1 | Cupping therapy for acute and chronic pain management:a systematic review of randomized clinical trials显示文摘Objective:Cupping as a traditional therapy is used to treat a myriad of health conditions,including pain.This systematic review assessed the effectiveness and safety of cupping for different types of pain.Methods:Thirteen databases and four trial registries were searched for randomized clinical trials.Meta-analysis of data was conducted if there was non-significant clinical and statistical heterogeneity(measured by I2 test)among trials.Results:Sixteen trials with 921 participants were eligible and included.Six trials were assessed as low risk of bias,another six trials were of unclear risk of bias,and the remaining four trials were of high risk of bias.Pain was related to three acute and seven chronic diseases.Metaanalysis showed a beneficial effect of cupping compared to wait-list control(visual analogue scale(VAS),MD1.85 cm,95%CI2.66 to1.04)and heat therapy(numerical rating scale,MD2.05 cm,95%CI2.93 to1.17).Cupping combined with acupuncture was superior to acupuncture alone on post-treatment pain intensity(VAS,MD1.18 cm,95%CI1.68 to0.68),however,no difference was found between this comparison based on changes in pain intensity(difference of VAS,MD 0.16 cm,95%CI0.54 to 0.87).Results from other single studies showed significant benefit of cupping compared with conventional drugs or usual care.Hematoma and pain at the treated site,increasing local pain or tingling were reported as mild adverse effects of cupping.Conclusion:This review suggests a potential positive short-term effect of cupping therapy on reducing pain intensity compared with no treatment,heat therapy,usual care,or conventional drugs. | Huijuan Cao Xun Li Xue Yan Nissi S.Wang Alan Bensoussan Jianping Liu | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，1： | 3 |
| 2 | Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis显示文摘 | Emilie A. Bard-Chapeau Shuangwei Li Jin Ding Sharon S. Zhang Helen H. Zhu Frederic Princen Diane D. Fang Tao Han Beatrice Bailly-Maitre Valeria Poli Nissi M. Varki Hongyang Wang Gen-Sheng Feng | 2011 | Cancer Cell2011，，5： | 2 |
| 3 | Prolyl 4- hydroxylase isoenzymes I and II have different expression patterns in several human tissues 显示文摘 | Nissi R Autio-Harmainen H Marttila P Sormunen R | 2001 | J Histochem Cytochem2001，49，： | 1 |
| 4 | Delayed gadolinium- enhanced MRI of cartilage (dGEMRIC) and T2 characteristics of human knee articular cartilage: topographical variation and rela- tionships to mechanical properties 显示文摘 | Kurkijarvi JE Nissi MJ Kiviranta I | 2004 | Magn Reson Med2004，52，1： | 1 |
| 5 | Assembly of human prolyl 4-hydroxylase and type III collagen in the yeast Pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires eoexpression with prolyl 4-hydroxylase 显示文摘 | Vuorela A Myllyharju J Nissi R | 1997 | EMBO J1997，16，22： | 1 |
| 6 | Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection显示文摘 | Rautiainen J Nissi M J Liimatainen T | 2014 | Osteoarthritis Cailage2014，22，10： | 1 |
| 7 | Delayed gadoliniurn-enhaneed MRI of eartilage(dGEMRIC) and T2 charaeteristics of human knee articular cartilage: topo- graphieal variation and relationships to mechanical prop- erties显示文摘 | Kurkijarvi JE Nissi MJ Kiviranta I | 2004 | Magn Reson Med2004，52，1： | 1 |
| 8 | Assembly of hu- manprolyl 4-hydroxylase and type I]I collagen in the yeast Pichiapastoris: formation of a stable enzyme tetramer re- quires coexpression with collagen and assembly of a stable collagen requires eoexpression with prolyl 4-hydroxyl- ase显示文摘 | Vuorela A Myllyharju J Nissi R | 1997 | The EMBO Journal1997，16，22： | 1 |
| 9 | Delayed gadoliniumenhanced MRI of cartilage (dGEMRIC) and T: characteristics of human knee articular cartilage: topographical variation and relationships to mechanical properties显示文摘 | Kurkijarvi JE Nissi MJ Kiviranta I | 2004 | Magn Reson Med2004，52，1： | 1 |
| 10 | Altered p53 and Bcl-2 expression in keratinocytes of vulvar lichen sclerosus during pimecrolimus treatment显示文摘 | Nissi R | 2009 | Br J Dermatol2009，161，4： | 1 |
| 11 | Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure显示文摘 | Nissi R Talvensaari-Mattila A Kotila V | 2013 | Reprod Biol Endocrinol2013，11，2： | 1 |
| 12 | T2 relaxation time mapping reveals age-and species-related diversity of collagen network architecture in articular cartilage显示文摘 | Nissi MJ Rieppo J Toyras J | 2006 | Osteoarthritis and Cartilage2006，14，12： | 1 |
| 13 | Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage显示文摘 | Nissi MJ Toyras J Laasanen MS | 2004 | Journal of Orthopaedic Research2004，22，： | 1 |
| 14 | Me-chanical characterization of articular cartilage bycombining magnetic resonance imaging and finite-el-ement analysis:apotential functional imaging tech-nique显示文摘 | Julkunen P Korhonen RK Nissi MJ | 2008 | Phys Med Biol2008，53，9： | 1 |
| 15 | Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure显示文摘 | Nissi R Talvensaafi-Mattila A Kotila V | 2013 | Reprod Biol Endecrinol2013，，11： | 1 |
| 16 | Immunofluorescence localization of prolyl 4-hydroxylase isoenzymes and type Ⅰ and Ⅱ collagens in bone tumours: type Ⅰ enzyme predominates in osteosareomas and chondrosareomas, whereas type Ⅱ enzyme predominates in their benign counterparts 显示文摘 | Nissi R Bohling T Autio-ftarmainen H | 2004 | Acta histochemica2004，106，： | 1 |
| 17 | Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage显示文摘 | Nissi MJ Toyras J Laasanen MS | 2004 | J Orthop Res2004，22，3： | 1 |
| 18 | IL-1β and TNF-α upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increasedAT1 density in the post-MI heart显示文摘 | Devorah G Randy TC Nissi V | 2005 | J Mol Cell Cardi2005，38，： | 1 |
| 19 | Assembly of human prolyI4-hydroxylase and typeⅢcollagen in the yeast pichial pastoris:formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl4-hydroxylase显示文摘 | Vuorela A Myllyharju J Nissi R | 1997 | The EMBO Joumal1997，16，22： | 1 |
| 20 | Proteoglyean and collagen sensitive MRI evaluation of normal and degenerated articular cartilage显示文摘 | Nissi M J Toyras J Laasanen M S | 2004 | J Orthop Res2004，22，3： | 1 |
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