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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage显示文摘AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit buffer.Desferrioxamine(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all stages.Effluent samples were collected after CS and after WI.Perfusate samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver perfusion.Cellular injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate samples.Total iron was analysed in the perfusate samples.After WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during WP.After 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and increased bile flow(DFO absent 71±8μL/g liver vs DFO present 237±36μL/g liver, P<0.05).DFO was also shown to improve liver morphology after WP.Cellular injury(the release of LDH and AST)was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion.There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION:DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. | Peter G Arthur Xian-Wa Niu Wen-Hua Huang Bastiaan DeBoer Ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 3 | Electroless Ni-P Deposition on Magnesium Alloy from a Sulfate Bath 显示文摘 | Li G Y Niu L Y Jiang Q | 2008 | Journal of Wuhan University of Technology - Mater2008，23，1： | 1 |
| 4 | Impact of gamma irradiation on the RF phase noise capability of UHV/CVD SiGe HBTs显示文摘 | Niu G Juraver J B Borgarino M | 2001 | Solid- State Electronics2001，45，： | 1 |
| 5 | Method for large-scale isolation and purification of R-phycoerythrin from red alga Polysiphonia urceolata Grev显示文摘 | NIU J F WANG G C TSENG C K | 2006 | Protein Expression and Purification2006，49，： | 1 |
| 6 | Electroless Ni-P deposition plus zinc phosphate coating on AZ 91D magnesium alloy显示文摘 | Lian J S Li G Y Niu L Y | 2006 | Surface and Coatings Technology2006，20，10： | 1 |
| 7 | Robust sliding mode design for uncertain stochastic systems based on H control method 显示文摘 | NIU Y G WANG Z D WANG X Y | 2010 | Optimal Control Applications and Methods2010，31，2： | 1 |
| 8 | Relationship between endothelial ni-tric oxide synthase gene polymorphisms and ischemic stroke: a me-ta-analysis 显示文摘 | Niu PP Yang G Zheng BK | 2013 | Acta Neurol Scand2013，128，3： | 1 |
| 9 | The WUSCHEL gene promotes vegetative-to-embryonic transition in Arabidopsis显示文摘 | ZUO J NIU Q W FRUGIS G | 2002 | The Plant Journal2002，30，3： | 1 |
| 10 | Nitrogen vacancy-promoted photocatalytic activity of graphitic carbon nitride显示文摘 | Niu P Liu G Cheng H M | 2012 | The Journal of Physical Chemistry C2012，116，11： | 1 |
| 11 | Strong association of methylenetetra- hydrofolate reductase gene C677T polymorphism with hypertension and hypertension-in-pregnancy in Chinese:a meta-analysis显示文摘 | NIU W Q YOU Y G QI Y | 2012 | J Hum Hypertens2012，26，4： | 1 |
| 12 | Lymphatic imaging:focus on imaging probes 显示文摘 | Niu G Chen X Y | 2015 | Theranostics2015，5，7： | 1 |
| 13 | Multi-resolution shape description and clustering of three-dimensional head data显示文摘 | NIU J W LI Z Z SALVENDY G | 2009 | Ergonomics2009，52，2： | 1 |
| 14 | A comparison of the effects of gamma irradiation on SiGe HBT and GaAs HBT technologies显示文摘 | Zhang S Niu G Cressler J D | 2000 | IEEE Trans on Nucl Sci2000，47，： | 1 |
| 15 | Agonists at PPAR-gamma suppress angiotensin II induced production of plasminogen activator inhibitor 1 and extracellular matrix in rat cardiac fibroblasts 显示文摘 | HAO G H NIU X L GAO D F | 2008 | Br J Pharmacol2008，153，7： | 1 |
| 16 | Constitutive STAT3 activity up-regulates VEGF expression and tumor angiogenesis显示文摘 | Niu G Wrisht KL Huang M | 2002 | Oncogene2002，21，13： | 1 |
| 17 | Tumor hypoxia imaging显示文摘 | Sun X Niu G Chan N | 2011 | Mol Imaging Biol2011，13，3： | 1 |
| 18 | An acute experimental model dem- oustrating 2 different form sustained atrial tachyarrhythmias 显示文摘 | Niu G Scherlag B J Lu Z | 2009 | Cire Arrhythm Electrophysiol2009，4，： | 1 |
| 19 | The WUSCHEL gene promotes vegetative -to- embryonic transition in Arabi- dopsis 显示文摘 | Zuo J Niu Q W Frugis G | 2002 | The Plant Journal2002，30，3： | 1 |
| 20 | Increasing the visible light absorption of graphitic carbon nitride(melon)photocatalysts by homogeneous self-modification with nitrogen vacancies显示文摘 | Niu P Yin L C Yang Y Q Liu G Cheng H M | 2014 | Advanced Materials2014，26，47： | 1 |
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