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| 1 | Mesoporous silica nanoparticles for drug and gene delivery显示文摘Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. | Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 31 |
| 2 | Time series models for salinity and other environmental factors in the apalachicola estuarine system显示文摘 | Niua X-F Edmiston H L Bailey G O | 1998 | Estuarine Coastal and Shelf Science1998，，46： | 1 |
| 3 | The Air Oxidation of T-wo-phas e Co-Cu Alloys at 600-800℃显示文摘 | Niua Y Songb J Cesmundoa F | 2000 | Corrosion Science2000，42，： | 1 |
| 4 | Tumor-induced upregulation of twist,snail,and slug represses the activity of the human VE-cadherin promoter显示文摘 | Lopeza DY Niua GL Huberb P | 2009 | Arch Biochem Biophys2009，482，12： | 1 |
| 5 | The influence of hydrogen sulfide on corrosion of iron under different conditions 显示文摘 | Quan Z L Zhao S Y Lin Niua | 2000 | Corrosion Science2000，42，10： | 1 |
| 6 | 查看详情显示文摘 | Niua S. Y Hana B Caoa W Zhang S.S | | 0，，： | 1 |
| 7 | On active vibration isolation of floating raft system显示文摘 | Niua Junehuan Songa Kongiie Lira C W | 2005 | Journal of Sound and Vibration2005，285，： | 1 |
| 8 | Instant formation of nanopores on flexible polymer membranes using intense pulsed light and nanoparticle templates显示文摘The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable devices.However,solidstate nanopores are typically realized by complex and highend nanofabrication equipments.Here,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating source.The density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 nm.After removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation identification.This low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis. | Miaoning Ren Tianyu Li Wenxing Huo Yu Guo Zhiqiang Xia Ya Lia Jing Niua M.Serdar Onses Xian Huang | 2023 | International Journal of Smart and Nano Materials2023，14，4： | 0 |
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