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| 1 | Mesoporous silica nanoparticles for drug and gene delivery显示文摘Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. | Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 31 |
| 2 | Quantum proxy signature scheme with public verifiability显示文摘In recent years, with the development of quantum cryptography, quantum signature has also made great achievement. However,the effectiveness of all the quantum signature schemes reported in the literature can only be verified by a designated person.Therefore, its wide applications are limited. For solving this problem, a new quantum proxy signature scheme using EPR quantumentanglement state and unitary transformation to generate proxy signature is presented. Proxy signer announces his public key whenhe generates the final signature. According to the property of unitary transformation and quantum one-way function, everyone canverify whether the signature is effective or not by the public key. So the quantum proxy signature scheme in our paper can be publicverified. The quantum key distribution and one-time pad encryption algorithm guarantee the unconditional security of this scheme.Analysis results show that this new scheme satisfies strong non-counterfeit and strong non-disavowal. | ZHOU JingXian ZHOU YaJian NIU XinXin YANG YiXian | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 6 |
| 3 | Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex显示文摘Pluripotent 干细胞(PSC ) 在他们的快速的增长和作为结果的染色体不稳定性期间怀有组成的 DNA 复制应力在再生药妨碍他们的应用。理解复制的规章的机制在 PSC 强调反应因此是重要的。这里,我们报导胚胎的干细胞(转换字符) 是的那只老鼠比在解决复制应力的区分的房间优异。明确地,转换字符利用唯一的跳动 Filia 的蛋白质高效地支持阻止的复制的重启的复杂依赖者的机制分叉,因此维持 genomic 稳定性。转换字符特定的跳动 Filia 的建筑群在正常条件下面住在复制叉上。复制应力刺激他们的招募到阻止 Filia 的 151 残余是的叉和丝氨酸以一种 ATR 依赖的方式的 phosphorylated。这修正使跳动 Filia 的建筑群能充当功能的脚手架,它然后通过双机制支持拖延的叉重启:复制叉重启蛋白质, Blm,和刺激 ATR kinase 激活的两提高的招募。在 Blm 小径,脚手架招募 E3 ubiquitin ligase, Trim25,到阻止的复制叉,并且接着, Trim25 通过 ubiquitination 在阻止的复制叉拴住并且专注 Blm。在区分的房间,到复制叉和 ATR 发信号的激活的 Trim25-Blm 建筑群的招募由于转换字符特定的跳动 Filia 的支架的缺乏是更不柔韧的。因此,我们的学习表明转换字符利用另外、唯一的规章的层高效地支持阻止的叉重启并且维持 genomic 稳定性。 | Bo Zhao Weidao Zhang Yixian Cun Jingzheng Li Yan Liu Jing Gao Hongwen Zhu Hu Zhou Rugang Zhang Ping Zheng | 2018 | Cell Research2018，28，1： | 4 |
| 4 | “Pincer movement”:Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles显示文摘The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers.Intracellular glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin resistance.Herein,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based chemotherapy.Specifically,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST inhibitor.Responding to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug release.Meanwhile,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug resistance.Moreover,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant melanoma.The in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth suppression.Overall,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers. | Boyi Niu Yixian Zhou Kaixin Liao Ting Wen Sixian Lao Guilan Quan Xin Pan Chuanbin Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 5 | BiVO_(4)/TiO_(2) heterojunction with rich oxygen vacancies for enhanced electrocatalytic nitrogen reduction reaction显示文摘The large-scale production of ammonia mainly depends on the Haber-Bosch process,which will lead to the problems of high energy consumption and carbon dioxide emission.Electrochemical nitrogen fixation is considered to be an environmental friendly and sustainable process,but its efficiency largely depends on the activity and stability of the catalyst.Therefore,it is imperative to develop high-efficient electrocatalysts in the field of nitrogen reduction reaction(NRR).In this paper,we developed a BiVO_(4)/TiO_(2) nanotube(BiVO_(4)/TNT)heterojunction composite with rich oxygen vacancies as an electrocatalytic NRR catalyst.The heterojunction interface and oxygen vacancy of BiVO_(4)/TNT can be the active site of N2 dynamic activation and proton transition.The synergistic effect of TiO_(2) and BiVO_(4) shortens the proton transport path and reduces the over potential of chemical reaction.BiVO_(4)/TNT has high ammonia yield of 8.54µg·h^(−1)·cm^(−2) and high Faraday efficiency of 7.70%in−0.8 V vs.RHE in 0.1 M Na_(2)SO_(4) solution. | Yunliang Liu Peiji Deng Ruqiang Wu Ramadan A.Geioushy Yaxi Li Yixian Liu Fengling Zhou Haitao Li Chenghua Sun | 2021 | Frontiers of physics2021，16，5： | 1 |
| 6 | Novel single-channel color image encryption algorithm based on chaos and frac- tional Fourier transform显示文摘 | Zhou Nanrun Wang Yixian | 2011 | Opt Commun2011，284，12： | 1 |
| 7 | Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells显示文摘 | Qinghao Liu Yixian Qin Lei Zhou Qiuwen Kou Xin Guo Xinna Ge Hanchun Yang Hongbo Hu | 2012 | Virology2012，，2： | 1 |
| 8 | Novel color im- age encryption algorithm based on the reality preserving fractional Mellin transforms 显示文摘 | Nanrnn Zhou Yixian Wang Lihua Gong | 2013 | Optics and Laser Technol- ogy2013，44，7： | 1 |
| 9 | Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues显示文摘Although the function of tRNAs in the translational process is well established,it remains controversial whether tRNA abundance is tightly associated with translational efficiency(TE)in mammals.Moreover,how critically the expression of tRNAs contributes to the establishment of tissue-specific proteomes in mammals has not been well addressed.Here,we measured both tRNA expression using demethylase-tRNA sequencing(DM-tRNA-seq)and TE of mRNAs using ribosome-tagging sequencing(RiboTag-seq)in the brain,heart,and testis of mice.Remarkable variation in the expression of tRNA isodecoders was observed among different tissues.When the statistical effect of isodecoder-grouping on reducing variations is considered through permutating the anticodons,we observed an expected reduction in the variation of anticodon expression across all samples,an unexpected smaller variation of anticodon usage bias,and an unexpected larger variation of tRNA isotype expression at amino acid level.Regardless of whether or not they share the same anticodons,the isodecoders encoding the same amino acids are co-expressed across different tissues.Based on the expression of tRNAs and the TE of mRNAs,we find that the tRNA adaptation index(tAI)and TE are significantly correlated in the same tissues but not between tissues;and tRNA expression and the amino acid composition of translating peptides are positively correlated in the same tissues but not between tissues.We therefore hypothesize that the tissue-specific expression of tRNAs might be due to post-transcriptional mechanisms.This study provides a resource for tRNA and translation studies,as well as novel insights into the dynamics of tRNAs and their roles in translational regulation. | Peng Yu Siting Zhou Yan Gao Yu Liang Wenbing Guo Dan Ohtan Wang Shuaiwen Ding Shuibin Lin Jinkai Wang Yixian Cun | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 10 | A New Method to Detect Useless Service Failure Model in SPN 显示文摘 | Zhao Mingfeng Zhou Yajian Yang Yixian | 2010 | Journal of Convergence Information Technology2010，5，3： | 1 |
| 11 | Novel single-channel color image encryption algorithm based on chaos and fractional Fourier transform显示文摘 | Nanrun Zhou Yixian Wang Lihua Gong Hong He Jianhua Wu | 2011 | Optics Communications2011，，12： | 1 |
| 12 | Novel single-channel color image encryption algorithm based on chaos and fractional Fourier transform显示文摘 | Nanrun Zhou Yixian Wang Lihua Gong Hong He Jianhua Wu | 2011 | Optics Communications2011，，12： | 1 |
| 13 | Analysis on Attenuation Efficiency of Lightning Current by Lightning Interceptor显示文摘Lightning interception technology is one of the three core technical systems of regional lightning protection theory.Among them,the omni-directional multi-pulse lightning interceptor(hereinafter referred to as lightning interceptor,the same below)has the ability to attenuate lightning current≥40%and significantly reduce the intensity of the spatial electromagnetic field around the lightning point.In order to explore the attenuation mechanism and effect of lightning interceptor to lightning current,this paper analyzed a lightning stroke process at 16:00 on August 19,2022,and tried to explain the attenuation effect of lightning interceptor to lightning current with the physical parameters of lightning stroke. | Hui YANG Zhongqiu SHI Renhong GUO Yixian QIU Qiaobin WEI Ruping ZHOU Yu HUANG | 2023 | Meteorological and Environmental Research2023，14，1： | 1 |
| 14 | Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells显示文摘 | Qinghao Liu Yixian Qin Lei Zhou Qiuwen Kou Xin Guo Xinna Ge Hanchun Yang Hongbo Hu | 2012 | Virology2012，，2： | 1 |
| 15 | Consistency of weighted feature set and polyspectral kernels in individual communication transmitter identification显示文摘This paper presents a method using support vector machine with polyspectral kernels for classification of individual transmitters.Then,the neighborhood-roughset-based weighted feature set is proposed.The experiments of the algorithms mentioned above indicate that they have consistency,which raises a new weighted kernel.The experiment shows that better classification rate can be achieved. | Na SUN Yajian ZHOU Yixian YANG | 2010 | Frontiers of Electrical and Electronic Engineering in China2010，5，4： | 0 |
| 16 | Degradation strategies of pesticide residue:From chemicals tosynthetic biology显示文摘The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects.To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution.In recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation.Combining the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation.This review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues. | Bi Ruomeng Ou Meihao Zhou Siru Geng Shichen Zheng Yixian Chen Junhong Mo Ruijie Li Yuan Xiao Gezhi Chen Xingyu Zhai Shiyi Zhang Aihui Fang Baishan | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 17 | Design and Mechanical Characterization of an S-Based TPMS Hollow Isotropic Cellular Structure显示文摘Cellular structures are regarded as excellent candidates for lightweight-design,load-bearing,and energy-absorbing applications.In this paper,a novel S-based TPMS hollow isotropic cellular structure is proposed with both superior load-bearing and energy-absorbing performances.The hollow cellular structure is designed with Boolean operation based on the Fischer-Koch(S)implicit triply periodic minimal surfaces(TPMS)with different level parameters.The anisotropy and effective elasticity properties of cellular structures are evaluated with the numerical homogenization method.The finite element method is further conducted to analyze the static mechanical performance of hollow cellular structure considering the size effect.The compression experiments are finally carried out to reveal the compression properties and energy-absorption characteristics.Numerical results of the Zener ratio proved that the S-based hollow cellular structure tends to be isotropic,even better than the sheet-based Gyroid TPMS.Compared with the solid counterpart,the S-based hollow cellular structure has a higher elastic modulus,better load-bearing and energy absorption characteristics. | Junjian Fu Pengfei Sun Yixian Du Lei Tian Qihua Tian Xiangman Zhou | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 0 |
| 18 | An Olefinic 1,2-α-Boryl Migration Enables 1,2-Bis(boronic esters)via Radical-Polar Crossover Reaction显示文摘A radical-induced 1,2-α-boryl migration through radical polar crossover reactions has been described.In this work,in situ formed vinyldiboron“ate”complexes from alkenyl Grignard reagent and diborylalkanes react with commercial radical precursors under light initiation.This three-component process enables diborylation of alkene.This protocol features high atom economy,a broad substrate scope as well as good functional group toleration with mild conditions. | Feng Zhang Shangteng Liao Lu Zhou Kai Yang Chenglan Wang Yixian Lou Cece Wang Qiuling Song | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 19 | Pyramiding of multiple genes generates rapeseed introgression lines with clubroot and herbicide resistance, high oleic acid content, and early maturity显示文摘Clubroot and herbicide resistance,high oleic acid(OA)content,and early maturity are targets of rapeseed(Brassica napus L.)breeding.The objective of this study was to develop new male-fertility restorer lines by pyramiding favorable genes to improve these traits simultaneously.Seven elite alleles for the four traits were introduced into the restorer line 621R by speed breeding with marker-assisted and phenotypic selection.Six introgression lines(ILs)were developed with four-to seven-gene combinations and crossed with two elite parents to develop hybrids.All ILs and their corresponding hybrids displayed high resistance to both clubroot pathotype 4 and sulfonylurea herbicides.Three ILs and their hybrids showed large increases in OA contents and four showed earlier maturity.These new ILs may be useful in rapeseed hybrid breeding for the target traits. | Zhaoyang Wang Fucai Wang Zihan Yu Xiaorui Shi Xianming Zhou Pengfei Wang Yixian Song Dengfeng Hong Guangsheng Yang | 2023 | The Crop Journal2023，11，3： | 0 |
| 20 | Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis显示文摘Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological processes.Therefore,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD treatment.Accordingly,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside XVII.Guided by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected region.This nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ phagocytosis.Resultantly,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic mice.Our research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy. | Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
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