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| 1 | Surgical strategy for bile duct cancer:Advances and current limitations显示文摘The aim of this review is to describe recent advances and topics in the surgical management of bile duct cancer.Radical resection with a microscopically negative margin(R0)is the only way to cure cholangiocarcinoma and is associated with marked survival advantages compared to margin-positive resections.Complete resection of the tumor is the surgeon’s ultimate aim,and several advances in the surgical treatment for bile duct cancer have been made within the last two decades.Multidetector row computed tomography has emerged as an indispensable diagnostic modality for the precise preoperative evaluation of bile duct cancer,in terms of both longitudinal and vertical tumor invasion.Many meticulous operative procedures have been established,especially extended hepatectomy for hilar cholangiocarcinoma,to achieve a negative resection margin,which is the only prognostic factor under the control of the surgeon.A complete caudate lobectomy and resection of the inferior part of Couinaud’s segmentⅣcoupled with right or left hemihepatectomy has become the standard surgical procedure for hilar cholangiocarcinoma,and pyloruspreserving pancreaticoduodenectomy is the first choice for distal bile duct cancer.Limited resection for middle bile duct cancer is indicated for only strictly selected cases.Preoperative treatments including biliary drainage and portal vein embolization are also indicated for only selected patients,especially jaundiced patients anticipating major hepatectomy.Liver transplantation seems ideal for complete resection of bile duct cancer,but the high recurrence rate and decreased patient survival after liver transplant preclude it from being considered standard treatment.Adjuvant chemotherapy and radiotherapy have a potentially crucial role in prolonging survival and controlling local recurrence,but no definite regimen has been established to date.Further evidence is needed to fully define the role of liver transplantation and adjuvant chemo-radiotherapy. | Nobuhisa Akamatsu Yasuhiko Sugawara Daijo Hashimoto | 2011 | World Journal of Clinical Oncology2011，2，2： | 27 |
| 2 | Living-donor vs deceased-donor liver transplantation for patients with hepatocellular carcinoma显示文摘With the increasing prevalence of living-donor liver transplantation(LDLT) for patients with hepatocellular carcinoma(HCC),some authors have reported a potential increase in the HCC recurrence rates among LDLT recipients compared to deceased-donor liver transplantation(DDLT) recipients.The aim of this review is to encompass current opinions and clinical reports regarding differences in the outcome,especially the recurrence of HCC,between LDLT and DDLT.While some studies report impaired recurrence- free survival and increased recurrence rates among LDLT recipients,others,including large database studies,report comparable recurrence- free survival and recurrence rates between LDLT and DDLT.Studies supporting the increased recurrence in LDLT have linked graft regeneration to tumor progression,but we found no association between graft regeneration/initial graft volume and tumor recurrence among our 125 consecutive LDLTs for HCC cases.In the absence of a prospective study regarding the use of LDLT vs DDLT for HCC patients,there is no evidence to support the higher HCC recurrence after LDLT than DDLT,and LDLT remains a reasonable treatment option for HCC patients with cirrhosis. | Nobuhisa Akamatsu Yasuhiko Sugawara Norihiro Kokudo | 2014 | World Journal of Hepatology2014，6，9： | 13 |
| 3 | Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis显示文摘AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. | Junmi Tanaka Hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 5 |
| 4 | Late-onset acute rejection after living donor liver transplantation显示文摘AIM: To investigate the incidence and risk factors of late-onset acute rejection (LAR) and to clarify the effectiveness of our immunosuppressive regime consisting of life-long administration of tacrolimus and steroids. METHODS: Adult living donor liver transplantation recipients (n = 204) who survived more than 6 mo after living donor liver transplantation were enrolled. Immunosuppression was achieved using tacrolimus and methylprednisolone. When adverse effects of tacrolimus were detected, the patient was switched to cyclosporine. Six months after transplantation, tacrolimus or cyclosporine was carefully maintained at a therapeutic level. The methylprednisolone dosage was maintained at 0.05 mg/kg per day by oral administration. Acute rejections that occurred more than 6 mo after the operation were defined as late-onset. The median follow- up period was 34 mo. RESULTS: LAR was observed in 15 cases (7%) and no chronic rejection was observed. The incidence of hyperlipidemia, chronic renal failure, new-onset post- transplantation diabetes, and deep fungal infection were 13%, 2%, 24%, and 17%, respectively. Conversion from tacrolimus to cyclosporine was required in 38 patients (19%). Multivariate analysis revealed that a cyclosporine- based regimen was significantly associated with LAR. CONCLUSION: Both LAR and drug-induced adverseevents happen at a low incidence, supporting the safety and efficacy of the present immunosuppression regimen for living donor liver transplantation. | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Junichi Keneko Yuichi Matsui Kiyoshi Hasegawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，41： | 4 |
| 5 | Efficacy of mycofenolate mofetil for steroid-resistant acute rejection after living donor liver transplantation显示文摘瞄准:在类固醇作为抑制免疫力的药讨论 mycophenolate mofetil (MMF ) 的使用在肝移植以后的抵抗拒绝。方法:经历了生活施主肝移植(LDLT ) 的 260 个成年病人的临床的记录被考察。Tacrolimus 和甲基氢化尼松被用于主要免疫力的抑制。尖锐拒绝首先与类固醇被对待。当类固醇抵抗发生了时,病人与类固醇和 MMF 的联合被对待。Anti-T-cell 单音的同种细胞的抗体予不对在有 MMF 的联合的类固醇应答的病人被以。结果:90 的一个总数(35%) 病人们开发了尖锐拒绝。第一个事件的从移植的中部的间隔时间是 15 d。54 个病人是类固醇抵抗。44 个病人与 MMF 并且留下被对待 10 要求的 anti-T-cell 单音的同种细胞的抗体治疗。到长期的拒绝的前进在一个病人被观察。骨髓抑制和胃肠的症状是与 MMF 使用联系的最普通的副作用。机会主义的感染没有重要增加。结论:我们的结果证明 MMF 为在有在 LDLT 以后的尖锐拒绝的病人的营救治疗是一个有势力和安全抑制免疫力的代理人。 | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Yuichi Matsui Junichi Kaneko Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，30： | 3 |
| 6 | Liver Transplantation and Hepatitis C显示文摘 | Nobuhisa Akamatsu Yasuhiko Sugawara Mario Reis Alvares-da-Silva | 2012 | International Journal of Hepatology2012，，： | 2 |
| 7 | Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa 显示文摘 | Nobuhisa M Eiko S Satoshi O | 1995 | Antimicrobial Agents Chemother1995，39，： | 1 |
| 8 | Chemical changes of kenaf core binderless boards during hot pressing (I) :influence of the pressing temperature condition 显示文摘 | Nobuhisa Okuda Keko Hori Masatoshi Sato | 2006 | Jap Wood Res Soc2006，，10： | 1 |
| 9 | Fuel consumption-derived CO 2 emissions under conventional and reduced tillage cropping systems in northern Japan显示文摘 | Nobuhisa Koga Haruo Tsuruta Hiroyuki Tsuji Hiroshi Nakano | 2003 | Agriculture Ecosystems and Environment2003，，1： | 1 |
| 10 | Free jejunal graft for hypopharyngeal and esophageal reconstruction显示文摘 | Yasuhiro Shirakawa Yoshio Naomoto Kazuhiro Noma Ryoko Ono Tetsuji Nobuhisa Masahiko Kobayashi Toshiya Fujiwara Hirofumi Noguchi Takaomi Ohkawa Tomoki Yamatsuji Minoru Haisa Junji Matsuoka Mehmet Gunduz Noriaki Tanaka | 2004 | Langenbeck’s Archives of Surgery2004，，5： | 1 |
| 11 | Heparanase Expression correlates with malignant potential in human colon cancer显示文摘 | Nobuhisa T Naomoto Y Ohkawa T | 2005 | J Cancer Res Clin Oncol2005，131，4： | 1 |
| 12 | Soluble adhesion molecules and C-reactive protein in the progression of silent cerebral infarction in patients with type 2 diabetes mellitus显示文摘 | Takahiko Kawamura Toshitaka Umemura Akio Kanai Masahito Nagashima Nobuhisa Nakamura Tomoko Uno Mikihiro Nakayama Takahisa Sano Yoji Hamada Jiro Nakamura Nigishi Hotta | 2006 | Metabolism2006，，4： | 1 |
| 13 | Three dimensional numerical model for flow and bed deformation around river hydraulic structures 显示文摘 | NOBUHISA N TAKASHI H TATSUAKI N | 2005 | Journal of Hydraulic Engineering2005，131，12： | 1 |
| 14 | Translocation of heparanase into nucleus results in cell differentiation 显示文摘 | Nobuhisa T Naomoto Y Okawa T | 2007 | Cancer Sci2007，98，4： | 1 |
| 15 | High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt 显示文摘 | NOBUHISA N KEIKO N YASUKO K | 2011 | J Diabetes Invest2011，2，4： | 1 |
| 16 | Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis 显示文摘 | Inoue T Kagawa T Inoue-Mochita M Isono K Ohtsu N Nobuhisa I | 2010 | FEBS Lett2010，584，14： | 1 |
| 17 | Enhancement of trans glutaminase activity by NMR identification of its flexible resi dues affecting the active site显示文摘 | Nobuhisa S Mina S Kei-ichi Y | 2002 | FEBS Letters2002，517，4： | 1 |
| 18 | Manufacture and Mechanical Properties of Binder Less Boards from Kenaf Core显示文摘 | OKUDA Nobuhisa SATO Masatoshi | 2004 | The Japan Wood Research and Society2004，50，： | 1 |
| 19 | Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire显示文摘 | Nobuhisa Maeno Kazunori Kusunoki Tsuyoshi Kitajima Nakao Iwata Yuichiro Ono Shuji Hashimoto Makoto Imai Lan Li Yuhei Kayukawa Tatsuro Ohta Norio Ozaki | 2004 | Journal of Affective Disorders2004，，： | 1 |
| 20 | COX-2 induction by heparanase in progression of progression of breast cancer 显示文摘 | Imada T Matsuoka J Nobuhisa T | 2006 | Int J Med2006，17，2： | 1 |
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