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| 1 | Hilar cholangiocarcinoma with intratumoral calcification: A case report显示文摘This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first,hepatolithiasis was diagnosed,and he underwent endoscopic stone extraction via the transpapillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital,and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification,while no stones were found. To the best of our knowledge,only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here,we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features. | Kazuho Inoko Takahiro Tsuchikawa Takehiro Noji Yo Kurashima Yuma Ebihara Eiji Tamoto Toru Nakamura Soichi Murakami Keisuke Okamura Toshiaki Shichinohe Satoshi Hirano | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 2 | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma显示文摘Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. | Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 3 | Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment显示文摘 | K. Ikeda Y. Shiga A. Takahashi T. Kai H. Kimura K. Takeyama H. Noji K. Ogawa A. Nakamura H. Ohira Y. Sato Y. Maruyama | 2006 | Leukemia & Lymphoma2006，，1： | 2 |
| 4 | A medical disaster response to reduce immediate mortality after an earthquake 显示文摘 | Schultz CH Koenig KL Noji EK | 1996 | N Engl J Med1996，334，7： | 1 |
| 5 | Cysteine synthase overexpression in tobacco confers tolerance to sulfur-containing environment pollutants显示文摘 | Noji M Saito M Nakamura M | 2001 | Plant Pbysiol2001，326，3： | 1 |
| 6 | A monoclonal antibody against COOH-terminal peptide of human liver manganese superoxide dismutase显示文摘 | Noji S Uda T | 1989 | J Biol Chem1989，264，： | 1 |
| 7 | Molecular cloning and sequence analysis of antigen gene tdpA of treponema denticola 显示文摘 | Miyamoto M Noji S Kokeguchi S | 1991 | Infect lmmun1991，59，6： | 1 |
| 8 | Direct observation of the rota- tion of F1-ATPase显示文摘 | NOJI H YASUDA R YOSHIDA M | 1997 | Nature1997，386，20： | 1 |
| 9 | The public health consequences of disasters显示文摘 | Noji EK | 2000 | Prehospital Disaster Med2000，15，14： | 1 |
| 10 | Expression of fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development,compared with Fgf15 expression in the mouse显示文摘 | Kurose H Bito T Adachi T Shimizu M Noji S Ohuchi H | 2004 | Gene Expr2004，4，6： | 1 |
| 11 | Numerical analysis of the ac losses of 500-m I-ITS power cable in Super-ACE project 显示文摘 | NOJI H | 2007 | Cryogenics 472007，，： | 1 |
| 12 | AC loss analysis of 114MVA high-To superconducting model cable显示文摘 | Noji H Haji K Hamada T | 2003 | Physica C2003，，392396： | 1 |
| 13 | Intraperitoneal injection of in vitro expanded vγgvδ2 T cells together with zoledronate for the treat- ment of malignant ascites due to gastric cancer 显示文摘 | Wada I Matsushita H Noji S | 2014 | Cancer Med2014，3，2： | 1 |
| 14 | Adenosine uptake inhibitors显示文摘 | NOJI T KARASAWA A KUSAKA H | 2004 | Eur J Pharmacol2004，495，1： | 1 |
| 15 | A medical disaster response to reduce immediate mortality after an earthquake显示文摘 | Schultz CH Koenig KL Noji EK | 1996 | N Engl J Med1996，334，26： | 1 |
| 16 | A transcriptional activation domain of ATMYB2, a drought-inducible Arabidopsis Myb-related protein 显示文摘 | Urao T Noji M Yamaguchi-Shinozaki K | 1996 | The Plant Journal1996，10，6： | 1 |
| 17 | CT evaluation of paraaortic lymph node metastasis in patients with biliary cancer 显示文摘 | Noji T Kondo S Hirano S | 2005 | J Gastroenterol2005，40，7： | 1 |
| 18 | Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics显示文摘Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level.ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction.To understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in mitochondria.Methods:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial ATP.We constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and consumption.Results:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two clusters.Cluster 1 showed strong transient increase,whereas cluster 2 showed weak transient increase.Mathematical modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster 2.Cluster 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle fibers.Conclusions Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller consumption.Cluster 1 might reflect the larger oxidative capacity of slow muscle fiber. | Naoki Matsuda Ken-ichi Hironaka Masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue Miki Eto Daisuke Hoshino Yasuro Furuichi Yasuko Manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda | 2020 | Quantitative Biology2020，8，3： | 1 |
| 19 | Different functional recovery of the left ventricle after valve replacement for aortic regurgitation:correlation between grade of ventricular arrhythmia and long term mortality显示文摘 | Noji S Kitanmura M Hachida M | 1995 | J Heart Valve Dis1995，4，： | 1 |
| 20 | Advances in disaster medicine 显示文摘 | Noji EK | 2002 | Eur J Emerg Med2002，9，2： | 1 |
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