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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Survival after pulmonary edema due to enterovirus 71 encephalitis显示文摘 | NOLAN N A CRAIG M E LAHRA M M | 2003 | Neurology2003，60，10： | 1 |
| 3 | Dysembryoplasticneuroepithelial tumors in childhood: long-term outcome andprognostic features 显示文摘 | Nolan MA Sakuta R Chuang N | 2004 | Nerology2004，62，： | 1 |
| 4 | The role of uhrauiolet irradiation and heparin-binding epidermal growth factor-lik growth factor in the pathogenesis of pterggium显示文摘 | Nolan TM di Girolamo N Sachdev NH | 2003 | Am J P2003，162，2： | 1 |
| 5 | Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the human lens:implications for cortical cataract formation显示文摘 | Sachdev N H Girolamo N D Nolan T M | 2004 | Invest Ophthalmol Vis Sci2004，45，11： | 1 |
| 6 | The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygium显示文摘 | Nolan TM DiGirolamo N Sachdev NH | 2003 | Am J Pathol2003，162，： | 1 |
| 7 | Dysembryoplastic neuroepithelial tumor in childhood: long-term outcome and prognostic feathures 显示文摘 | Nolan MA Sakuta R Chuang N | 2004 | Neurology2004，62，6： | 1 |
| 8 | Insulin resistance as a physiological defense against metabolic stress:implications for the management of subsets of type 2diabetes显示文摘 | Nolan C J Ruderman N B Kahn S E | 2015 | Diabetes2015，64，3： | 1 |
| 9 | Experimental exposure of rainbow trout Oncorhynchus mykiss (Walbaum) to the infective stages of the sea louse Lepeophtheirus salmonis (Kroyer) influences the physiological response to an acute stressor 显示文摘 | Ruane N M Nolan D T Rotllant J | 2000 | Fish & Shellfish Immunology2000，10，5： | 1 |
| 10 | Mechanisms of ANCA - mediated leukocyte - endothelial cell interactions in vivo 显示文摘 | Nolan S L Kalia N Nash G B | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 11 | Dysembryoplastic neuroepithelial tumors in childhood:long term outcome and prongostic features显示文摘 | Nolan M A Sakuta R Chuang N | 2004 | Neuroleg2004，62，12： | 1 |
| 12 | Cationic copper (Ⅰ) complexes as efficient precatalysts for the hydrosilylation of carbonyl compounds显示文摘 | GONZALEZ S D SCOTT N M NOLAN S P | 2006 | Organometallics2006，25，9： | 1 |
| 13 | Mapping normal and cancer cell signalling net- works: towards single-cell proteomies 显示文摘 | Irish JM Koteeha N Nolan GP | 2006 | Nat Rev Cancer2006，6，2： | 1 |
| 14 | Adjustments in gait symmetry with walking speed in trans-femoral and trans-tibial amputees显示文摘 | Nolan L Wit A Dudzi(n)ski K | | 0，，02： | 1 |
| 15 | Assimilation of metals in marine copepods and its biogeochemical implications显示文摘 | Fisher N S Nolan C V Fowler S W | 1991 | Marine Ecology Progress Series1991，71，： | 1 |
| 16 | Spatial Patterns of Robbery at Tourism Sites : A Case Study of the Vieux Carre in NewOrleans显示文摘 | Harper D W Khey D N Nolan G M | 2012 | Southern Criminal Justice Association2012，38，4： | 1 |
| 17 | Perceptions of Inequity,Satisfaction,and Conflict in Task-Oriented Groups显示文摘 | Nolan N | 1996 | Human Relations1996，39，： | 1 |
| 18 | Expasion of peripheral blood CD5+B cells is associated with mild disease in chronic hepatitis C virus infection显示文摘 | Curry MP Golden-Mason L Nolan N | 2000 | J Hepatol2000，32，1： | 1 |
| 19 | Dynamic stability of wind turbine generators显示文摘 | Hinrinchsenand E N Nolan P J | 1982 | PAS IEEE Trans on1982，101，3： | 1 |
| 20 | Effect of N doping on the photocatalytic activity of sol-gelTiO2显示文摘 | Nolan N T Synnott D W Seery M K Hinder S J Van Wassenhoven A Pillai S C | 2012 | Journal of Hazardous Materials2012，，： | 1 |
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