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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | Epidemiological,clinical and laboratory findings of infectious keratitis at Mansoura Ophthalmic Center,Egypt显示文摘● AIM: To analyze the epidemiological, clinical and laboratory findings of infectious keratitis. ● METHODS: A retrospective study on cases of infective keratitis, attended our institution from Mar. 2013 to Feb. 2015, was done at Mansoura Ophthalmic Center, Egypt. Corneal scrapings were performed and processed for direct microscopy and culture in appropriate media using standard laboratory protocols. ● RESULTS: Out of 245 patients enrolled for study, 247 corneal scrapings were obtained. Ocular trauma was the most common predisposing factor(51.4%), followed by diabetes mellitus(15.1%). Cultures were positive in 110 scraping samples(44.5%): 45.5% samples had pure fungal infection, 40% had pure bacterial infections and 10% had mixed fungal and bacterial growths. Acanthamoeba was detected in 5(4.5%) samples. The most common fungal pathogen was Aspergillus spp.(41%). The most common bacterial isolates were Staphylococcus aureus(38.2%) and Pseudomonas aeruginosa(21.8%).● CONCLUSION: Incidence of fungal keratitis is high in our region. Therapeutic approach can initially be based on clinical features and sensitivity/resistance patterns. Microbiological research should direct the antimicrobial treatment. Antibiotic resistance to fluoroquinolones and aminoglycosides is an important consideration. | Amani E Badawi Dalia Moemen Nora L El-Tantaw | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 2 |
| 3 | Magnesia-phosphate bond for cold- settingcordierite-based refractories显示文摘 | Nora E Hipdinger | 2002 | Cement and Concrete Research2002，32，： | 1 |
| 4 | XAFS characterization of mercury captured from combustion gases on sorbents at low temperatures显示文摘 | Frank E H Nora Y Gerald P H | | 0，，02： | 1 |
| 5 | Magnesia-ammonium phosphate-bonded cordierite refractory castables:phase evolution on heating and mechanical properties显示文摘 | NORA E H ALBERTON S ESTEBAN F A | 2004 | Cem Concr Res2004，34，1： | 1 |
| 6 | A comparision of the performance of two chromatographic and three extraction techniques for the analysis of PAHs in Sources of Drinking Water显示文摘 | Nora E Dlaz - Moroles Humberto J Garza - Ulloa Rocfo Castro - Rlosl | 2007 | J Chromatogr A2007，45，1： | 1 |
| 7 | Complement activation determines the therapeutic activity of rituximab in vivo 显示文摘 | Di Gaetano N Cittera E Nora R | 2003 | J Immunol2003，171，： | 1 |
| 8 | Toxoplasma gondii infection among chronic hepatitis C patients:A casecontrol study显示文摘Objective:To determine the detection rate of anti-Toxoplasma gondii(T.gondii) IgG and IgM in chronic HCV patients attending the Department of Tropical Medicine Mansoura University hospital in Egypt.Methods:This study included 120 adult chronic HCV patients.81 decompensate cirrhosis(late-stage)and 39 chronic HCV non cirrhotic patients(early-stage) and40 healthy blood donors as controls.Serum samples uere examined for anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies by ELISA.Real-time RT-polymerase chain reaction assay was done for quantitation of hepatitis C virus.Results:Anti-T.gondii IgG antibodies were detected in 75(92.6%) of 81 late-stage cirrhotic patients.30(76.9%) of the 39 chronic HCV non cirrhotic patients(early-Stage) and in 6(15ft) of 40 controls with statistically significant difference(P<0.001).Anti-T.gondii IgM antibodies were found in 11(13.6%) in late stage patients,5(12.8%)in early stage and in 3(7.5%) of controls with no statistical significant difference(P=0.610).There was no correlation between stage of fibrosis and IgM or IgG antibodies positivity in our studied groups(P=0.526).High IgG levels significantly correlated with high viral load(P=0.026).Conclusions:Our findings suggest that the serious opportunistic T.gondii infection represent a potential significant risk for chronic HCV patients.So.toxoplasmosis should be considered in their investigations and follow-up. | Hala A El-Nahas Nora L El-Tantawy Raghda E Farag Argaya MA Alsalem | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，8： | 1 |
| 9 | The inactive X chromo some adopts a unique three din, ensional conformation that is dependent on Xist RNA显示文摘 | Splinter g Wit E Nora E P | 2011 | Genes Dev2011，25，13： | 1 |
| 10 | Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity 显示文摘 | Matthias B Stefan E Nora K | 2006 | Diabetes2006，55，11： | 1 |
| 11 | Spatial partitioning of the regulatory landscape of the X inactivation center 显示文摘 | Nora E P Lajoie B R Schulz E G | 2013 | Nature2013，485，7398： | 1 |
| 12 | RNA interference guides histone modification during the S phase of chromosomal replication 显示文摘 | Kloc A Zaratiegui M Nora E | 2008 | Curr Biol2008，18，7： | 1 |
| 13 | Study of solid acid catalysis for the hydration of a-pinene 显示文摘 | Avila Maria C Comellia Nora A Rodriguez-Castellon E | 2010 | Journal of Molecular Catalysis A2010，322，12： | 1 |
| 14 | Increased collagen synthesis by scleroderma skin fibroblasts in vitro 显示文摘 | E Carwile LR Mary MG Nora C | 1974 | J Clin Invest1974，54，10： | 1 |
| 15 | Randomized controlled study of stroke unit care versus stroke team care in different stroke subtypes 显示文摘 | Andrew E Farzaneh H Nora D | 2002 | Stroke2002，33，2： | 1 |
| 16 | Brain-derived neurotrophic factor plasma levels:relationship with dementia and diabetes in the elderly population显示文摘 | Passaro A Dalla Nora E Morieri ML | 2015 | J Gerontol A Biol Sci Med Sci2015，70，3： | 1 |
| 17 | Bizarre parosteal osteochondromatous proliferations of the hands and feet 显示文摘 | Nora F E Dahlin D C Beabout J W | 1983 | Am J Surg Pathol1983，7，3： | 1 |
| 18 | Regulation of X-chromosome inactivation by the X-inactivation centre显示文摘 | Augui S Nora E P Heard E | | 0，，06： | 1 |
| 19 | ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice显示文摘 | Murphy Andrew J Akhtari Mani Tolani Sonia Pagler Tamara Bijl Nora Kuo Chao-Ling Wang Mi Sanson Marie Abramowicz Sandra Welch Carrie Bochem Andrea E Kuivenhoven Jan Albert Yvan-Charvet Laurent Tall Alan R | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 20 | 2011 The inactive X chromosome adopts au- nique threedimensional conformation that is dependent on Xist RNA显示文摘 | Splinter E de Wit E Nora E P Klous P van de Werken H J Zhu Y Kaaij L J van ljcken W Gribnau J Heard E de Laat W | 2011 | Genes Development2011，25，13： | 1 |
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