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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | HPLC residues of enrofloxacin and ciprofloxacin in eggs of layings hens显示文摘 | NORA G ENRIQUE C LAURA U | 1997 | International Journal of Antimicrobial Agents1997，8，： | 1 |
| 3 | Development of laser dimpling strategies on TiN coatings for tribological applications with a highly energetic Q-switched fibre laser显示文摘 | Ali G?khan Demir Barbara Previtali Nora Lecis | 2013 | Optics and Laser Technology2013，，： | 1 |
| 4 | An evaluation of the 30s chair stand test in older adults:frailty detection based on kinematic parameters from a single inertial unit显示文摘 | Nora M Pablo L Marisol G | 2013 | J Neuro- eng Rehabil2013，10，1： | 1 |
| 5 | Biomass and composition of the phytoplankton in the south eastern large-scale distribution and rela- tionship with environmental variables during a spring cruise 显示文摘 | Danilo C Monica G Nora G | 2005 | Cont Shelf Res2005，25，： | 1 |
| 6 | Linear equalizers with dynamic and automatic length selection显示文摘 | Riero-Palou F Noras J M Cruickshank D G M | 2001 | Electron Lett2001，37，25： | 1 |
| 7 | The inactive X chromo some adopts a unique three din, ensional conformation that is dependent on Xist RNA显示文摘 | Splinter g Wit E Nora E P | 2011 | Genes Dev2011，25，13： | 1 |
| 8 | Spatial partitioning of the regulatory landscape of the X inactivation center 显示文摘 | Nora E P Lajoie B R Schulz E G | 2013 | Nature2013，485，7398： | 1 |
| 9 | Preparation of Microstructured and Nanostructured Magnetic Materials by Mechan- ical Deformation 显示文摘 | Alexandre G Nguyen H H Nora D | 2002 | Journal of Magnetism and Magnetic Materi- als2002，242，245： | 1 |
| 10 | Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole显示文摘 | Lewis Brittany B. Buffie Charlie G. Carter Rebecca A. Leiner Ingrid Toussaint Nora C. Miller Liza C. Gobourne Asia Ling Lilan Pamer Eric G | 2015 | Journal of Infectious Diseases2015，，10： | 1 |
| 11 | Cleaning up contaminants with plants显示文摘 | JENNIFER C NORA G | 2005 | Biocycle2005，46，8： | 1 |
| 12 | Variable length equalizers for broadband mobile systems 显示文摘 | Felip R P Noras J M David G M | 2000 | Proceedings of IEEE VTC2000，9，5： | 1 |
| 13 | The State of Garbage in America显示文摘 | Scott M K Nora G Karsten M | 2004 | Biocycle2004，45，1： | 1 |
| 14 | Exploiting the intrinsic hydrocarbon-degrading microbial capacities in oil tank bottom sludge and waste soil for sludge bioremediation显示文摘 | NORA B S PAULINE V G ALETTE A M L | 2015 | International Journal of Environmental Science and Technology2015，12，： | 1 |
| 15 | Modifications of thesympathetic skin response in workers chronically exposed to lead显示文摘 | Nora D B Gomes I Said G | 2007 | Braz J Med Biol Res2007，40，1： | 1 |
| 16 | Lin- ear equalizers with dynamic and automatic length selection显示文摘 | RIERA-PALOU F NORAS J M CRUICKSHANK D G M | 2001 | Electronics Letters2001，37，25： | 1 |
| 17 | Linear equalizerswith dynamic and automatic length selection显示文摘 | Riera P F Noras J M Cruickshank D G M | 2001 | Electronics Letters2001，37，25： | 1 |
| 18 | Linear equalizers with dynamic and automatic lengthselection 显示文摘 | Riera-palou F Noras J M Cruickshank D G M | 2001 | Electronics Letters2001，37，25： | 1 |
| 19 | Modifications of the sympathetic skin response in workers chronically exposed to lead 显示文摘 | Nora DB Gomes I Said G | 2007 | Braz J Med Biol Res2007，40，1： | 1 |
| 20 | Linear equalizers, with dynamic and automatic length selection 显示文摘 | RIERA-PALOU F NORAS J M CRUICKSHANK D G M | 2001 | Elec- tronics Letters2001，37，25： | 1 |
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