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| 1 | Adiponectin as a protective factor in hepatic steatosis显示文摘AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. | Nahum Méndez-Sánchez Norberto C.Chávez-Tapia Antonio R.Villa Karla Sánchez-Lara Daniel Zamora-Valdés Martha H.Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，12： | 12 |
| 2 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 3 | Detailed modelling of a flue-gas desulfurisation plant显示文摘 | Antonio Gómez Norberto Fueyo Alfredo Tomás | 2006 | Computers and Chemical Engineering2006，，11： | 2 |
| 4 | Blueberry' anthocya- nins in health promotion: A metabolic overview 显示文摘 | NORBERTO S SARA S MANUELA M | 2013 | Journal of Functional Foods2013，5，4： | 1 |
| 5 | New butenolides in plantlets of Virola surinamensis (Myristicaceae) 显示文摘 | NORBERTO P L PIERRE A D S MASSUO J K | 2004 | Chem Pharm Bull2004，52，10： | 1 |
| 6 | Tracking of regions-of-interest in myocardial contrast echocardiography显示文摘 | Norberto M Andres S Miguel AZ | 2004 | Ultrasound in Med and Biol2004，30，3： | 1 |
| 7 | Functional characterization of the hypothalamic–pituitary–adrenal axis of the Wistar Audiogenic Rat (WAR) strain显示文摘 | Eduardo H.L. Umeoka Sérgio Britto Garcia José Antunes-Rodrigues Lucila L.K. Elias Norberto Garcia-Cairasco | 2011 | Brain Research2011，，： | 1 |
| 8 | Transesterication reaction of vegetable ils, using superacid sulfated TiO2-base catalysts显示文摘 | Rusiene M de Almeida Lucia K Noda Norberto S Goncalves | 2008 | Applied Catalysis A: General2008，347，： | 1 |
| 9 | Mast cell degranulation promotes microvascular responses to systemic hypoxia 显示文摘 | Steiner Dawn R S Gonzalez Norberto C Wood John G | 2002 | FASEB Journal2002，16，5： | 1 |
| 10 | Role of diet in cholesterol gallstone formation显示文摘 | Nahum Méndez-Sánchez Daniel Zamora-Valdés Norberto C. Chávez-Tapia Misael Uribe | 2006 | Clinica Chimica Acta2006，，1： | 1 |
| 11 | Management of perceptions of information technology service quality显示文摘 | Luís Kalb Roses Norberto Hoppen Jorge Luiz Henrique | | 0，，9： | 1 |
| 12 | Analysis of the immune response to FMDV structural and non-structural proteins in cattle in Argentina by the combined use of liquid phase and 3ABC-ELISA tests显示文摘 | Blanca R Cristina S Norberto F | 2006 | Vaccine2006，24，7： | 1 |
| 13 | Determination of caffeine and its metabolites in urine by capillary electrophoresismass spectrometry显示文摘 | PERI - OKONNY U WANG S X JOHN R S NORBERTO A G | 2005 | Electrophoresis2005，26，13： | 1 |
| 14 | Mycophenolate mofetil versus AZAthioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial显示文摘 | Giuseppe R Mariadomenica L Eliana G Maria G Borislav DD Bogdan EI Giulia G Donato D Maurizio S Silvio S Umberto V Giuseppe S Georges M Stefano F Paolo R Vito S Jean-Louis B Norberto P Piero R | 2004 | Lancet2004，364，7： | 1 |
| 15 | blueberry anthocya- nins in health promotion: A metabolic overview 显示文摘 | Norberto S Sara S Manuela M | 2013 | Journal of functional foods2013，，5： | 1 |
| 16 | Butanolides as a common feature of Iryanthera Lancifolia and Virola Surinamensis显示文摘 | Norberto P L Dulce H S S Massuo J K | 1998 | Phytochemiswy1998，49，5： | 1 |
| 17 | The potential for electricity generation from crop and forestry residues in Spain显示文摘 | Antonio Gómez Marcos Rodrigues Carlos Monta?és César Dopazo Norberto Fueyo | 2010 | Biomass and Bioenergy2010，，5： | 1 |
| 18 | Bile Duct Growing Factor: An Alternate Technique for Reconstruction of Thin Bile Ducts After Iatrogenic Injury显示文摘 | Miguel ángel Mercado Héctor Orozco Carlos Chan Carlos Quezada Alexandra Barajas-Olivas Daniel Borja-Cacho Norberto Sánchez-Fernandez | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 19 | Wireless sensor networks for temperature and humidity monitoring within concrete structures显示文摘 | Norberto Barroca Luís M. Borges Fernando J. Velez Filipe Monteiro Marcin Górski Jo?o Castro-Gomes | 2012 | Construction and Building Materials2012，，： | 1 |
| 20 | Endoscopic palliation of esophageal cancer;results of a prospective comparison of Nd:YAG laser and ethanol injection显示文摘 | Norberto L Ranzato R Marino S | 1999 | Eur J Surg1999，12，： | 1 |
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