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| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | Adiponectin as a protective factor in hepatic steatosis显示文摘AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. | Nahum Méndez-Sánchez Norberto C.Chávez-Tapia Antonio R.Villa Karla Sánchez-Lara Daniel Zamora-Valdés Martha H.Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，12： | 12 |
| 3 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 4 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 5 | Blueberry' anthocya- nins in health promotion: A metabolic overview 显示文摘 | NORBERTO S SARA S MANUELA M | 2013 | Journal of Functional Foods2013，5，4： | 1 |
| 6 | Eosinophilic Gastroenteritis: A Review显示文摘 | Nahum Méndez-Sánchez Norberto C. Chávez-Tapia Genaro Vazquez-Elizondo Misael Uribe | 2007 | Digestive Diseases and Sciences2007，，11： | 1 |
| 7 | Tracking of regions-of-interest in myocardial contrast echocardiography显示文摘 | Norberto M Andres S Miguel AZ | 2004 | Ultrasound in Med and Biol2004，30，3： | 1 |
| 8 | Low-molecular-weight heparin for prevention of venous thromboembolism after varicose vein surgery in moder- ate-risk patients: a randomized, controlled trial 显示文摘 | San Norberto Garcia E M Merino B Taylor J H | 2013 | Ann Vase Surg2013，27，7： | 1 |
| 9 | Transesterication reaction of vegetable ils, using superacid sulfated TiO2-base catalysts显示文摘 | Rusiene M de Almeida Lucia K Noda Norberto S Goncalves | 2008 | Applied Catalysis A: General2008，347，： | 1 |
| 10 | Semiochemicals from larval food affect the locomotory behaviour of Varroa destructor显示文摘 | FRANCESCO N NORBERTO M GIORGIO D | 2001 | Apidologie2001，，3： | 1 |
| 11 | Role of diet in cholesterol gallstone formation显示文摘 | Nahum Méndez-Sánchez Daniel Zamora-Valdés Norberto C. Chávez-Tapia Misael Uribe | 2006 | Clinica Chimica Acta2006，，1： | 1 |
| 12 | C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation显示文摘 | Sara B Simona M Norberto P | | 0，，09： | 1 |
| 13 | Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection显示文摘 | Natalia Rubinstein Mariano Alvarez Norberto W Zwirner Marta A Toscano Juan M Ilarregui Alicia Bravo José Mordoh Leonardo Fainboim Osvaldo L Podhajcer Gabriel A Rabinovich | 2004 | Cancer Cell2004，，3： | 1 |
| 14 | Mycophenolate mofetil versus AZAthioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial显示文摘 | Giuseppe R Mariadomenica L Eliana G Maria G Borislav DD Bogdan EI Giulia G Donato D Maurizio S Silvio S Umberto V Giuseppe S Georges M Stefano F Paolo R Vito S Jean-Louis B Norberto P Piero R | 2004 | Lancet2004，364，7： | 1 |
| 15 | Modeling Starburst Cells' GABAB Receptors and Their Putative Role in Motion Sensitivity显示文摘 | Norberto M Grzywacz Charles L Zucker | 2006 | Biophys J2006，91，2： | 1 |
| 16 | blueberry anthocya- nins in health promotion: A metabolic overview 显示文摘 | Norberto S Sara S Manuela M | 2013 | Journal of functional foods2013，，5： | 1 |
| 17 | The competition between acetate and pyrazolate in the forma- tion of polynuclear Zn(Ⅱ ) coordination complexes显示文摘 | AUGUSTO C I SIMONA G NORBERTO M | 2006 | Dalton Transactions2006，20，： | 1 |
| 18 | Shotgun wound and pellet embolism to the intracranial carotid artery 显示文摘 | Vaquero-Puerta C San Norberto E M Mrtino B | 2012 | J Vase Surg2012，55，2： | 1 |
| 19 | Combined analysis of prenatal ( maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides 显示文摘 | Enrique M Ostrea Jr Dawn M Bielawski Norberto C Poseeion Jr | 2009 | Environ Research2009，109，1： | 1 |
| 20 | Separation of scattering and absorption contributions in UV/visible spectra of resonant systems显示文摘 | NORBERTO M FRANCESCO M MARIANGELA C | 2001 | Anal Chem2001，73，： | 1 |
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