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| 1 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 2 | Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-basedchemotherapy显示文摘 | Tomojiro Ono Hideyuki Ishida Kensuke Kumamoto Norimichi Okada Keiichiro Ishibashi | 2012 | Oncology Letters2012，，5： | 2 |
| 3 | Difference in amounts and composition of dew from different types of dew collectors显示文摘 | Norimichi Takenaka Hiroyuki Soda Keiichi Sato | 2003 | Water A ir and Soil Pollution2003，147，： | 2 |
| 4 | Characterization of mastoparan-induced histamine release from RBL-2H3 cells显示文摘 | Kouichi Mizuno Norimichi Nakahata Yasushi Ohizumi | 1998 | Toxicon1998，，3： | 1 |
| 5 | Anti-allergic effects of cnidii monnieri fructus(dried fruits of Cnidium monnieri) and its major component,osthol显示文摘 | Hideaki Matsuda Norimichi Tomohiro Yasuko Ido | 2002 | Biol Pharm Bull2002，25，6： | 1 |
| 6 | Neuroendocrine Differentiation in Hormone Refractory Prostate Cancer Following Androgen Deprivation Therapy显示文摘 | Daisaku Hirano Yasuhiro Okada Sadatsugu Minei Yukie Takimoto Norimichi Nemoto | 2003 | European Urology2003，，5： | 1 |
| 7 | Regio and stereoselective oxidation of gem-dimethyl olefins via -sigmatropic rearrangement of allyl amine oxides 显示文摘 | Seiichi I Norimichi I Osamu M | 1986 | Chem Lett1986，，12： | 1 |
| 8 | A study on adhesion between wheels and rails in wheel slipping for high availability of braking force显示文摘 | Kumagai Norimichi Hasegawa Izumi | 2004 | Japan Society of Mechanical Engineers2004，70，1： | 1 |
| 9 | Impact of NOx reduction on long-term ozone trends in an urban atmosphere 显示文摘 | Yasuyuki Itano Hiroshi Bandow Norimichi Takenaka Yoshiyuki Saitoh Atsushi Asayama Joji Fukuyama | 2007 | Science of the Total Environment2007，379，1： | 1 |
| 10 | Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models显示文摘 | Norimichi Koitabashi Djahida Bedja Ari L. Zaiman Yigal M. Pinto Manling Zhang Kathleen L. Gabrielson Eiki Takimoto David A. KassZ | 2009 | Circulation Research2009，，1： | 1 |
| 11 | Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice显示文摘 | Takimoto Eiki Koitabashi Norimichi Hsu Steven Ketner Elizabeth A Zhang Manling Nagayama Takahiro Bedja Djahida Gabrielson Kathleen L Blanton Robert Siderovski David P Mendelsohn Michael E Kass David A | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 12 | Difference in amounts and composition of dew from different types of dew collectors,Water,air,and Pollution显示文摘 | Hiroyuki Soda | 2003 | Atmos Environ2003，147，： | 1 |
| 13 | Changes in evaporation rate and vapor pressure of gasoline with progress of evaporation显示文摘 | Katsuhiro Okamoto Norimichi Watanabe Yasuaki Hagimoto Koji Miwa Hideo Ohtani | 2009 | Fire Safety Journal2009，，5： | 1 |
| 14 | Application of image-based skin chromophore analysis to cosmetics 显示文摘 | Nobutoshi Ojima Norimichi Tsumura Syuuichi Akazaki | 2004 | Journal of Imaging Science and Technology2004，48，3： | 1 |
| 15 | Thromboxane A2: physiology/pathophysi- ology, cellular signal transduction and pharmacology显示文摘 | Norimichi N | 2008 | Pharmacol Therapeut2008，118，1： | 1 |
| 16 | Thermal degradation mechanism of a, 7-diphenyl alkyl allophanate as a model polyurethane by pyrolysis-high-resolution gas chromatography /FT-IR显示文摘 | NORIMICHI YOSHITAKE MUTSUHISA FURUKAWA | 1995 | Journal of Analytical and Applied Pyrolysis1995，33，： | 1 |
| 17 | 显示文摘 | Shinsaku H Norimichi K Noritsugu U | 2003 | Machining Science and Technology2003，7，： | 1 |
| 18 | Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer显示文摘 | Tatsuya M Norimichi O Keiichiro I | 2008 | Jpn J Clin Oncol2008，38，： | 1 |
| 19 | Effect of calcium and magnesium on neurotoxicity and blood platinum concentrations in patients receiving mFOLFOX6 therapy: a prospective randomized study显示文摘 | Keiichiro I Norimichi O Tatsuya M | 2010 | IntJ Clin Oncol2010，15，1： | 1 |
| 20 | Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis 显示文摘 | Norimichi K Masashi A Shinya K | 2007 | California Circ2007，49，5： | 1 |
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