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| 1 | Intestinal barrier in inflammatory bowel disease显示文摘A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms.In this review,we provide an overview about the major components of this protective system as for example an intact epithelium,the synthesis of various antimicrobial peptides(AMPs)and the formation of the mucus layer.We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease.Barrier disturbances including a defective production of AMPs,alterations in thickness or composition of the intestinal mucus layer,alterations of pattern-recognition receptors,defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis. | Lena Antoni Sabine Nuding Jan Wehkamp Eduard F Stange | 2014 | World Journal of Gastroenterology2014，20，5： | 33 |
| 2 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense显示文摘 | Zora Teltschik Reiner Wiest Julia Beisner Sabine Nuding Claudia Hofmann Juergen Schoelmerich Charles L. Bevins Eduard F. Stange Jan Wehkamp | 2012 | Hepatology2012，，： | 2 |
| 3 | Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin显示文摘 | SCHROEDER B O WU Z H NUDING S | 2011 | Nature2011，469，： | 1 |
| 4 | Association of late-life changes in blood pressure and cognitive status显示文摘BackgroundDisagreement 在血压和认知缺陷在在变化之间的协会上存在。我们试图检验在收缩、心脏舒张的血压( SBP 和 DBP )的4年的变化是否从一件基于人口的德国样品(年老的 60-87 年)的 854 个参加者在老人的一件代表性的样品和纵的数据的 women.MethodsAnalysis 与认知地位被联系与标准认知屏蔽和血被执行迫使大小。在 SBP 和 DBP 的变化的效果(10 mmHg 和 5 mmHg 分别地作为回归效果联合起来测量) 用非参量、线性的回归 modeling.ResultsNo 在认知地位上被评估清楚的协会在 SBP 或在 DBP 和认知分数在变化之间被看见。小效果为性别和高血压了解在层化以后被发现。明确地,在 SBP 的更大的减少在知道他们的高血压的那些人与更高认知的分数被联系(在 SBP 的 10 mmHg 减少, β=− 0.26, 95% CI:− 0.51 到 − 0.02 ) 并且有控制高血压的人(在 SBP 的 10 mmHg 减少, β=− 0.44, 95% CI:− 0.92 到 − 0.03 ) 。DBP 的另外更大的增加与控制高血压在人与更高认知的分数被联系(DBP 的 5 mmHg 增加, β= 0.67, 95% CI:0.19-1.15 ) 。为知道他们的高血压的女人,在 DBP 的更大的减少与更高认知的分数被联系(在 DBP 的 5 mmHg 减少, β=− 0.26;95%CI:− 0.51 到 − 0.01 ) 在血压的 .ConclusionsChanges 仅仅微弱地与认知地位被联系。明确地,在 SBP 的减少在知道他们医学上被控制的高血压和特别那些的男人与更高认知的分数被联系。 | Maria E Lacruz Daniel Tiller Alexander Kluttig Karin H Greiser Sebastian Nuding Karl Werdan Johannes Haerting | 2016 | Journal of Geriatric Cardiology2016，13，1： | 1 |
| 5 | A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts显示文摘 | Nuding S Fellermann K Wehkamp J | 2006 | J Microbiol Meth2006，65，2： | 1 |
| 6 | Phytosoeiology of an alteredran ge from the Depressao Central of Rio Grande doSul,Brasil显示文摘 | Nudes G E lob B I | | 0，，52： | 1 |
| 7 | correlation between successful heterotransplants, poor prognosis and amplification of the Her- 2/neu oncogene显示文摘 | Vardeman DM Willams LJ Heterotransplantation of human breast carcinomas in nude mice | 1991 | Int J Cancer1991，47，： | 1 |
| 8 | Ivabradine in combination with betablocker improves symptoms and quality of life in patients with stable angina pectoris:results from the ADDITIONS study显示文摘 | Werdan K Ebelt H Nuding S | 2012 | Clin Res Cardiol2012，101，： | 1 |
| 9 | Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1显示文摘 | Schroeder B O Wu Z H Nuding S | | 0，，： | 1 |
| 10 | The host and the flora显示文摘 | Nuding S Antoni L Stange EF | 2013 | Dig Dis2013，31，34： | 1 |
| 11 | Ivabradine in combination with beta-blocker improves symptoms and quality of life in pa?tients with stable angina pectoris: results from the ADDITIONS study显示文摘 | Werdan K Ebelt H Nuding S | 2012 | Clin Res Cardiol2012，101，5： | 1 |
| 12 | Arsenic contamination and secondary mineral evaluation in mine drainage using inte- grated acid-base accounting and toxicity characterisation leach-ing procedure :The case of Obuasi Mine,Ghana显示文摘 | FOLI G GAWU S K Y NUDE P M | 2015 | Environ- mental Earth Sciences2015，73，12： | 1 |
| 13 | Thermo stability and magnetic properties of FeSiB amorphous alloy显示文摘 | NUDES E PEREIRA R D FREITAS J C C PASSAMANI E C LARICA C FERNANDES A R SANCHEZ F H | 2006 | J Mater Sci Lett2006，41，： | 1 |
| 14 | Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1显示文摘 | Schroeder BO Wu Z Nuding S | | 0，，7330： | 1 |
| 15 | Antibacterial activity of human defensins on anaerobic intestinal bacterial species : a major role of HBD-3 显示文摘 | Nuding S Zabel L T Enders C | 2009 | Microbes Infect2009，11，3： | 1 |
| 16 | Reduction of disulphide bonds unmasks potent antimicrobial activity of human betadefensin 1 显示文摘 | Schroeder BO Wu Z Nuding S | 2011 | Nature2011，469，： | 1 |
| 17 | Human colonic mucus is a reservoir for antimicrobial peptides显示文摘 | Lena Antoni Sabine Nuding Dagmar Weller Michael Gersemann German Ott Jan Wehkamp Eduard F. Stange | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 18 | Reduction of disulphide bonds unmasks potent antimicrobial activity of humanβ-defensin1显示文摘 | Schroeder BO Wu ZH Nuding S | 2011 | Nature2011，469，7330： | 1 |
| 19 | Impaired chemoreflex sensitivity in adult patients with multiple organ dysfunction syndrome - the potential role of disease severity 显示文摘 | Schmidt H Muller- Werdan U Nuding S | 2004 | Intensive Care Med2004，30，4： | 1 |
| 20 | Groundwater evolution in the Voltaian Basin,Ghana-an application of multivariate statistical analyses to hydrochemical data显示文摘 | NUDE P M BANOENG-YAKUBO B SAKYI P A | 2011 | Natural Science2011，3，10： | 1 |
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