|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 2 | Avascular necrosis of the talus:current treatment options显示文摘 | Horst F Gilbert BJ Nunley JA | | 0，，： | 1 |
| 3 | Long - term functional outcomes after opera- tive treatment for intra - articular fractures of the calcaneus 显示文摘 | Potter MQ Nunley JA | 2009 | J Bone Joint Surg Am2009，91，8： | 1 |
| 4 | Fractures of the elbow's lateral column radial head and capitellum显示文摘 | Rizzo M Nunley J A | 2002 | Hand Clin2002，18，3： | 1 |
| 5 | Concomitant fractures of the capitellum and radial head显示文摘 | Ward WG Nunley JA | 1988 | J Orthop Trauma1988，2，2： | 1 |
| 6 | Potential donor rotational bone grafts using vascular territories in the foot and ankle显示文摘 | Gilbert BJ Horst F Nunley JA | | 0，，： | 1 |
| 7 | The management of soft tissue problems associated with calcaneal fractures显示文摘 | Levin LS Nunley JA | 1993 | Clin Orthop Relat Res1993，，290： | 1 |
| 8 | Symptomatic adjacent segment disease after cervical total disc replacement:re-examining the clinical and radiological evidenee with established criteria显示文摘 | Nunley PD Jawahar A Cavanaugh DA | 2013 | Spine J2013，13，1： | 1 |
| 9 | Biomechanical and functional testing of plate fixation devices for proximal phalangeal fractures显示文摘 | Nunley A Kloen P Durham NC | 1991 | J Hand Surg(Am)1991，16，6： | 1 |
| 10 | Classification,investigation,and management of midfoot sprains:Lisfianc injuries in the athlete显示文摘 | Nunley JA Vertullo CJ | 2002 | Am J Sports Med2002，30，6： | 1 |
| 11 | Combined modality therapy of esthesioneuroblastoma 显示文摘 | McLean JN Nunley SR Klass CM | 2007 | Otolaryngol Head Neck Surg2007，136，6： | 1 |
| 12 | The prognostic val- ue of serum progesterone and quantitative beta-human ehorionie gonadotropin in early human pregnancy 显示文摘 | Daily CA Lanrent SL Nunley WC Jr | 1994 | Am J Obstet Gynecol1994，171，2： | 1 |
| 13 | Long-term functional outcomes after operative treatment for intra-articular fracture of the calcaneus显示文摘 | Potter MQ Nunley JA | 2009 | J Bone Joint Surg Am2009，91，8： | 1 |
| 14 | Concomitant fractures of the eapitellum and radial head显示文摘 | Ward WG Nunley JA | | 0，，02： | 1 |
| 15 | Risk of the Achilles tendon after partial excision for treatment of insertional tendonitis and Haglund's deformity: a biomechsnical study 显示文摘 | Kolodziej P Glisson R R Nunley J A | 1999 | Foot Ankle Int1999，20，11： | 1 |
| 16 | Fractures of the base of the fifth metatarsal: the Jones fracture显示文摘 | Nunley JA | 2001 | Orthop Clin North Am2001，1，： | 1 |
| 17 | Choice of plate may affect outcomes for single versus multilevel ACDF:re- sults of a prospective randomized single - blind trial显示文摘 | Nunley P D Jawahar A Kerr E J | 2009 | Spine J2009，9，： | 1 |
| 18 | Long-term functional outcomes after operative treatment for intra-articular fractures of the Calcaneus显示文摘 | Potter MQ Nunley JA | 2009 | J Bone Joint Surg Am2009，91，8： | 1 |
| 19 | Classification,investigation,and management of midfoot sprains显示文摘 | Nunley JA Vertullo CJ | 2002 | American Journal of Sports Medicine2002，30，6： | 1 |
| 20 | Symptomatic adjacent segment disease after cervical total disc replacement:re-examining the clinical and radiological evidence with established criteria显示文摘 | Nunley PD Jawahar A Cavanaugh DA | 2013 | Spine J2013，13，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员