|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Design and characterization of clindamycin-loaded nanofiber patches composed of polyvinyl alcohol and tamarind seed gum and fabricated by electrohydrodynamic atomization显示文摘In this study, we developed a polymeric nanofiber patch(PNP) for topical disease treatment using electrohydrodynamic atomization(EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol(PVA) and tamarind seed gum and loaded with clindamycin HCl as a model drug. The precursor polymer solutions were sprayed using the EHDA technique; the EHDA processing parameters were optimized to obtain blank and drug-loaded PNPs. The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application. The conductivity of the polymer solution increased with increasing PVA and clindamycin concentrations, and increasing the PVA concentration enhanced the solution viscosity. Based on scanning electron microscopy analysis, the PVA concentration had a pronounced effect on the morphology of the sprayed product. Nanofibers were fabricated successfully when the solution PVA concentration was 10%, 13%, or 15%(w/v). The applied voltage significantly affected the diameters of the prepared nanofibers, and the minimum nanofiber diameter was 163.86 nm. Differential scanning calorimetry and X-ray diffraction analyses indicated that the modeldrug was dispersed in PVA in an amorphous form. The PNP prepared with a PVA:gum ratio of 9:1 absorbed water better than the PVA-only PNP and the PNP with a PVA:gum ratio of 9.5:0.5. Moreover, the PNPs loaded with clindamycin at concentrations of 1%–3% prohibited the growth of Staphylococcus aureus more effectively than clindamycin gel, a commercially available product. | Tanikan Sangnim Sontaya Limmatvapirat Jurairat Nunthanid Pornsak Sriamornsak Wancheng Sittikijyothin Sumaleea Wannachaiyasit Kampanart Huanbutta | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 2 | Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity显示文摘The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac(SHL) nanofibers loaded with an antimicrobial monolaurin(ML). The main and interaction effects of formulation and process parameters including SHL content(35%–40% w/w), ML content(1%–3% w/w), applied voltage(9–27 kV) and flow rate(0.4–1.2 ml/h) on the characteristic of nanofibers were investigated through a total of 19 experiments based on a full factorial design with three replicated center points. As a result, the SHL content was the major parameter affecting fiber diameter. Another response result revealed that the SHL content would be also the most significant negative impact on amount of beads. An increase in the concentration of SHL leaded to a reduction in the amount of beads. From the results of characterization study, it was proved that ML might be entrapped between the chains of SHL during the electrospinning process exhibiting an excellent encapsulation. According to the response surface area, small(?488 nm) and beadless(?0.48) fibers were obtained with the SHL and ML contents of 37.5% and 1.1% w/w respectively, at the applied voltage of 18 k V and the flow rate of 0.8 ml/h. In addition, the results of the kill-kinetic studies showed that SHL nanofibers loaded with ML exhibited an excellent antibacterial activity against Staphylococcus aureus, while Escherichia coli was less affected due to the hydrophilic structure of the its outer membrane. ML also exerted an antifun-gal activity by reducing the number of Candida albicans colonies. Based on their structural and antimicrobial properties, SHL nanofibers containing ML could be potentially used as a medicated dressing for wound treatment. | Nawindac Chinatangkul Chutima Limmatvapirat Jurairatb Nunthanid Manee Luangtana-Anan Pornsak Sriamornsak Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 3 | Drug physical state and drug-polymer interaction on drug release from chitosan matrix films 显示文摘 | Puttipipatkhachorn S Nunthanid J Yamamoto K | 2001 | Journal of Control Rel2001，75，： | 1 |
| 4 | Drug physical state and drug -polymer interaction on drug release from chitosan matrix films 显示文摘 | S Puttipipatkhachorn J Nunthanid K Yamamoto | 2001 | Jounal of controlled Release2001，75，： | 1 |
| 5 | Characterization of chitosan acetate as a binder for sustained release tablets显示文摘 | Nunthanid J Laungtana M Sriamornsak P | 2004 | Journal of Controlled Release2004，99，1： | 1 |
| 6 | Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropylmethylcellulose 显示文摘 | Nunthanid J Huanbutta K Luangtana-anan M | 2008 | Eur J Pharm Biopharm2008，68，2： | 1 |
| 7 | Drug physical state and drug-polymer interaction on drug release from chitosan matrix films显示文摘 | PUTTIPIPATKHACHORN S NUNTHANID J YAMAMOTO K | 2001 | J Control Release2001，75，12： | 1 |
| 8 | Characterization of chitosan acetate as a binder for sustained release tablets显示文摘 | J. Nunthanid M. Laungtana-anan P. Sriamornsak S. Limmatvapirat S. Puttipipatkhachorn L.Y. Lim E. Khor | 2004 | Journal of Controlled Release2004，，1： | 1 |
| 9 | Drug physical state and drug-polymer interaction on drug release from ehltosan matrix films 显示文摘 | Puttipipatkhaehom S Nunthanid J Yamamoto K | 2001 | J Control Release2001，75，12： | 1 |
| 10 | Physical properties and molecular behavior of chitosan films显示文摘 | Nunthanid J Puttipipatkhachorn S Yamamoto K Peck G E | 2001 | Drug Dev Ind Pharm2001，，27： | 1 |
| 11 | Atomic force microscopy imaging of novel self-assembling pectin-liposome nanocomplexes显示文摘 | Sriamornsak P Thirawong N Nunthanid J | 2008 | Carbohydrate Polymers2008，71，： | 1 |
| 12 | Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropyl methylcellulose显示文摘 | Nunthanid J Huanbutta K Luangtana anan M etal | 2008 | Eur J Pharm Biopharm2008，681，： | 1 |
| 13 | Characterization of chitosan acetate as a binder for sustained release tablets显示文摘 | Nunthanid J Laungtana-Anan M Sriamornsak P | 2004 | J Control Release2004，99，1： | 1 |
| 14 | Atomic force microscopy imaging of novel self-assembling pectin-liposome nanocomplexes显示文摘 | SRIAMORNSAK P THIRAWONG N NUNTHANID J | 2008 | Carbohyd Polym2008，71，2： | 1 |
| 15 | Characteriza- tion of chitosan acetate as a binder for sustained release tablets 显示文摘 | Nunthanid J Laungtana-anan M Sriamomsak P | 2004 | Journal of Controlled Release2004，99，1： | 1 |
| 16 | Development of time-, pH-, and enzymecontrolled colonic drug delivery using spray-dried ehitosan acetate and hydroxypropyl methylcellulose 显示文摘 | Nunthanid Jurairat Huanbutta Kampanart Luangtana Manee | 2008 | Eur J Pharm Biopharm2008，68，2： | 1 |
| 17 | Alginate-based pellets prepared by extrusion/ spheronization: A preliminary study on the effect of additive in granulating liquid 显示文摘 | SRIAMORNSAK P NUNTHANID J LUANGTANA-ANAN M | 2007 | Eur J Pharm Biopharm2007，67，1： | 1 |
| 18 | Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process显示文摘 | Sontaya Limmatvapirat Chutima Limmatvapirat Satit Puttipipatkhachorn Jurairat Nunthanid Manee Luangtana-anan Pornsak Sriamornsak | 2008 | European Journal of Pharmaceutics and Biopharmaceutics2008，，3： | 1 |
| 19 | Drug physical state and drug-polymer interaction on drug release from chitosan matrix films显示文摘 | PUTrIPIPATKHACHORN S NUNTHANID J YAMAMOTO K | 2001 | Journal of controlled release2001，75，12： | 1 |
| 20 | Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer 显示文摘 | Thirawong N Nunthanid J Puttipipatkhachorn S | 2007 | Ear J Pharm Biopharm2007，67，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员