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| 1 | The effect of surfactant on the physical properties of coconut oil nanoemulsions显示文摘The aim of this study was to develop the water compatible form of coconut oil through nanoemulsification. The effect of different types and amounts of surfactants on the physical characteristics of nanoemulsions containing coconut oil was investigated. Coconut oil nanoemulsions containing varied amounts of surfactants including polyethylene glycol octyl phenyl ether(PGO), polyoxyethylene sorbitan monostearate(POS), polyethylene glycol hydrogenated castor oil(PHC), sodium lauryl sulfate(SLS) and poloxamer 407(PLX) were formulated and comparatively evaluated for their physical properties. The results showed that the coconut oil nanoemulsions using PGO, POS and PHC as surfactants exhibited low percent creaming index indicating excellent stability, while those containing SLS and PLX demonstrated the higher percent creaming index suggesting lesser physical stability. The droplet sizes of nanoemulsions consisting of 5%(w/w) PGO, POS and PHC were 22.843, 4.458 and 0.162 μm, respectively. Thus, coconut oil nanoemulsions with the smallest size could be obtained when PHC was applied. Furthermore, the droplet size of nanoemulsions decreased from 33 μm to less than 200 nm with an increase in the amount of PHC from 1% to 10%(w/w). Additionally, the properties of coconut oil based nanoemulsions containing PHC were not changed through temperature cycling test. From these results, it was suggested that the fabrication of stable coconut oil nanoemulsions with small particle size could be easily achieved by using 5%(w/w) PHC as a surfactant. The knowledge gained from the study might provide the basic guideline for the fabrication of stable nanoemulsions for food, cosmetic and pharmaceutical fields in the future. | Sirikarn Pengon Nawinda Chinatangkul Chutima Limmatvapirat Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 3 |
| 2 | A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution显示文摘To enhance the dissolution of poorly soluble mefenamic acid,self-emulsifying formulation(SEF),composing of oil,surfactant and co-surfactant,was formulated.Among the oils and surfactants studied,Imwitor■ 742,Tween■ 60,Cremophore■ EL and Transcutol■ HP were selected as they showed maximal solubility to mefenamic acid.The ternary phase diagram was constructed to find optimal concentration that provided the highest drug loading.The droplet size after dispersion and drug dissolution of selected formulations were investigated.The results showed that the formulation containing Imwitor■ 742,Tween■ 60 and Transcutol■ HP(10:30:60)can encapsulate high amount of mefenamic acid.The dissolution study demonstrated that,in the medium containing surfactant,nearly 100% of mefenamic acid were dissolved from SEF within 5 min while 80% of drugs were dissolved from the commercial product in 45 min.In phosphate buffer(without surfactant),80% of drug were dissolved from the developed SEF within 5 min while only about 13% of drug were dissolved in 45 min,from the commercial product.The results suggested that the SEF can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug. | Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 3 |
| 3 | Determination of mono-, di-, and trilaurin in modified coconut oil using HPLC–ELSD显示文摘Modified coconut oil (MCO) enriched with monolaurin (ML) was prepared by the glycerolysis of coconut oil (1)Glycerolysis converts dilaurin (DL) and trilaurin (TL) into ML, the lauric acid monoglyceride. ML has been found to have antiviral, antibacterial and antifungal activities (2)According to the antimicrobial activity, the glyceride composition of MCO was determined. | Juthaporn Ponphaiboon Sirikarn Pengon Amornrat Chaidedgumjorn Sontaya Limmatvapirat Chutima Limmatvapirata | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 2 |
| 4 | Design and characterization of clindamycin-loaded nanofiber patches composed of polyvinyl alcohol and tamarind seed gum and fabricated by electrohydrodynamic atomization显示文摘In this study, we developed a polymeric nanofiber patch(PNP) for topical disease treatment using electrohydrodynamic atomization(EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol(PVA) and tamarind seed gum and loaded with clindamycin HCl as a model drug. The precursor polymer solutions were sprayed using the EHDA technique; the EHDA processing parameters were optimized to obtain blank and drug-loaded PNPs. The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application. The conductivity of the polymer solution increased with increasing PVA and clindamycin concentrations, and increasing the PVA concentration enhanced the solution viscosity. Based on scanning electron microscopy analysis, the PVA concentration had a pronounced effect on the morphology of the sprayed product. Nanofibers were fabricated successfully when the solution PVA concentration was 10%, 13%, or 15%(w/v). The applied voltage significantly affected the diameters of the prepared nanofibers, and the minimum nanofiber diameter was 163.86 nm. Differential scanning calorimetry and X-ray diffraction analyses indicated that the modeldrug was dispersed in PVA in an amorphous form. The PNP prepared with a PVA:gum ratio of 9:1 absorbed water better than the PVA-only PNP and the PNP with a PVA:gum ratio of 9.5:0.5. Moreover, the PNPs loaded with clindamycin at concentrations of 1%–3% prohibited the growth of Staphylococcus aureus more effectively than clindamycin gel, a commercially available product. | Tanikan Sangnim Sontaya Limmatvapirat Jurairat Nunthanid Pornsak Sriamornsak Wancheng Sittikijyothin Sumaleea Wannachaiyasit Kampanart Huanbutta | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 5 | Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity显示文摘The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac(SHL) nanofibers loaded with an antimicrobial monolaurin(ML). The main and interaction effects of formulation and process parameters including SHL content(35%–40% w/w), ML content(1%–3% w/w), applied voltage(9–27 kV) and flow rate(0.4–1.2 ml/h) on the characteristic of nanofibers were investigated through a total of 19 experiments based on a full factorial design with three replicated center points. As a result, the SHL content was the major parameter affecting fiber diameter. Another response result revealed that the SHL content would be also the most significant negative impact on amount of beads. An increase in the concentration of SHL leaded to a reduction in the amount of beads. From the results of characterization study, it was proved that ML might be entrapped between the chains of SHL during the electrospinning process exhibiting an excellent encapsulation. According to the response surface area, small(?488 nm) and beadless(?0.48) fibers were obtained with the SHL and ML contents of 37.5% and 1.1% w/w respectively, at the applied voltage of 18 k V and the flow rate of 0.8 ml/h. In addition, the results of the kill-kinetic studies showed that SHL nanofibers loaded with ML exhibited an excellent antibacterial activity against Staphylococcus aureus, while Escherichia coli was less affected due to the hydrophilic structure of the its outer membrane. ML also exerted an antifun-gal activity by reducing the number of Candida albicans colonies. Based on their structural and antimicrobial properties, SHL nanofibers containing ML could be potentially used as a medicated dressing for wound treatment. | Nawindac Chinatangkul Chutima Limmatvapirat Jurairatb Nunthanid Manee Luangtana-Anan Pornsak Sriamornsak Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 6 | Enhanced enteric properties and stability of shellac films through composite salts formation显示文摘 | Sontaya L Chutima L Satit P | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，67，3： | 1 |
| 7 | Formation of shellac succinate having improved enteric film properties through dry media reaction显示文摘 | Sontaya L Danuch P Chutima L | 2008 | European Journal of Pharmaceutics and Biopharmaceutics2008，70，13： | 1 |
| 8 | Formulation and evaluation of gels containing coconut? kernel extract for topical application显示文摘The biological activity of coconut( Cocos nucifera L.) extracts from its kernels and various parts was reported by many previous studies, it is therefore believable that the extracts of its kernels might show some activities in topical formulations. Among several kernel extracts, the TC06 extract prepared by soaking the steamed coconut kernels in hot water showed the highest total phenolic content(6.98 ± 0.30 mg GAE/g extract) and the strongest antioxidant activity as determined using FRAP and DPPH methods with a reducing power value of 4.12 ± 0.16 mg AAE/g of extract and an SC 50 value of 2.38 ± 0.14 mg/ml, respectively. In addition, this extract did not display any cytotoxic effects in the concentration range of 50–3200 μg/ml. Meanwhile, it revealed cytoprotective effects against t-BHP-induced cytotoxicity in HaCaT cells at concentrations higher than 400 μg/ml. The results of phytochemical investigations including a chemical color test, TLC, 1 H NMR and FTIR suggested that the TC06 extract was mainly composed of flavonoids and terpenoids. Furthermore, the concentrations of heavy metals including As, Cd, Hg, and Pb in the TC06 extract were below permissible limits. According to the solubility, the TC06 extract was incorporated into gels using Carbopol Ultrez 21 as a gelling agent. The formulated gel containing 3%(w/w) TC06 extract was stable at 4 °C and 25 °C with 75% RH throughout the storage period. It was found that the Carbopol Ultrez 21-based hydroalcoholic gel containing an aqueous extract of coconut kernels exhibited antioxidant activities in the two assays and showed a sufficient consistency, a pleasing color, and a non-oily perception during the period of observation. | Wantanwa Krongrawa Sontaya Limmatvapirat Nushjira Pongnimitprasert Paranee Meetam Chutima Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 1 |
| 9 | Optimal growth conditions and the cultivation of Chaetoceros calcitrans in airlift photobioreactor显示文摘 | Sontaya K Worapannee L Sorawit P | 2005 | Chemical Engineering Journal2005，，105： | 1 |
| 10 | Optimal growth conditions and the cultivation of Chaetoceros calcitrans in airlift photobioreactor 显示文摘 | Sontaya Krichnavaruk Worapannce Loataweesup Sorawit Powtongsook | 2005 | Chemical Engineering Journal2005，105，3： | 1 |
| 11 | Factors affecting formation of nanoemulsions containing modified coconut oil and spearmint oil显示文摘Dental caries is one of the major oral health problems in most countries,affecting more than 50%of school children and majority of adults.Normally,we can prevent the disease by utilization of suitable antiseptics,e.g.alcohols and chlorhexidine[1].However,most antiseptics cause irritation or straining of the mucous membrane and teeth.Therefore,finding a more safe and efficient antiseptics is still a matter of interest to eradicate the causative pathogen.Volatile oils from plants including spearmint oil(SMO)could reduce the number of Streptococcus mutans counts in plaques and saliva. | Kamonchanok Wangjit Chutima Limmatvapirat Nattawat Nattapulwat Wanchai Sutananta Sontaya Limmatvapirat | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 1 |
| 12 | Supercritical carbon dioxide extraction of astaxanthin from Haematococcus pluvialis with vegetable oils as co-solvent 显示文摘 | Sontaya Krichnavaruk Artiwan Shotipruk Motonobu Goto | 2008 | Bioresource Technology2008，，99： | 1 |
| 13 | Dissolution improvement by solid dispersions composed of nifedipine, Eudragit?E and silica from rice husk显示文摘Nifedipine is a practically water-insoluble drug used therapeutically as a calcium-channel blocker for systemic and coronary vasodilation.Poorly soluble drugs that undergo dissolution rate-limited gastrointestinal absorption generally show increased bioavailability when dissolution is improved by formulation techniques[1].In solid dispersion system,a drug may exist as an amorphous form in polymeric carriers,and this may result in improved solubility and dissolution rate as compared with crystalline drug.Solid dispersion can be prepared by either fusion or solvent method[2]. | Pornsak Sriamornsak Srisuda Konthong Sontaya Limmatvapirat Supakij Suttiruengwong | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 1 |
| 14 | Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process显示文摘 | Sontaya Limmatvapirat Chutima Limmatvapirat Satit Puttipipatkhachorn Jurairat Nunthanid Manee Luangtana-anan Pornsak Sriamornsak | 2008 | European Journal of Pharmaceutics and Biopharmaceutics2008，，3： | 1 |
| 15 | An approach for the enhancement of the me- chanical properties and film coating efficiency of shellac by the formation of composite films based on shellac and gelatin显示文摘 | Sitthiphong Soradech Jurairat Nunthanid Sontaya Lim- matvapirat | 2012 | Journal of Food Engineering2012，108，1： | 1 |
| 16 | Modification of physicochemical and mechanical properties of shellac by partial hydrolysis显示文摘 | Sontaya Limmatvapirat Chutima Limmatvapirat Manee Luangtana-anan | 2004 | International Journal of Pharmaceutics2004，278，4： | 1 |
| 17 | Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique显示文摘 | Srisagul Sungthongieen Omlaksana Paeratakul Sontaya Limmatvapirat | 2006 | Inter J Pharm2006，324，： | 1 |
| 18 | Supercritical carbon dioxide extraction of astaxanthin from haematococcus pluvialis with vegetable oils as co-solvent显示文摘 | Sontaya Krichnavaruk Artiwan Shotipruk Motonobu Goto | | 0，，13： | 1 |
| 19 | Enhanced enteric properties and stability of shellac films through composite salts formation 显示文摘 | Sontaya L Chutima L Satit P | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，67，3： | 1 |
| 20 | Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles显示文摘The aims of this study were to prepare and characterize hydroxypropyl methylcellulose(HPMC)/polycarbophil(PC) mucoadhesive blend films saturated with propranolol hydrochloride(PNL)-loaded nanoparticles to improve permeability of drugs that undergo firstpass metabolism. An ionic cross-linking method and film casting technique was used to prepare nanoparticles and mucoadhesive blend films, respectively. Increasing concentrations of PNL(70, 80, 90 mg/film) in HPMC/PC blend films containing PNL-loaded nanoparticles(PN-films) and HPMC/PC blend films containing PNL(80 mg/film) without nanoparticles(PPfilms) were prepared to test swelling, mucoadhesiveness, release, permeation and physicochemical properties. Scanning electron microscope(SEM) images showed a partially smooth surface with a wrinkled occurrence and spherically shaped, well-dispersed nanoparticles on the surface of PN-films containing PNL 80 mg/film(PN-films-80). The size of the nanoparticles on the surface of PN-films-80 was around 100 nm, which was similar to the nanoparticle size observed using light scattering technique. The swelling index(SI)of all PN-films and PP-films increased greatly in the first period time(10–20 min) and reached swelling equilibrium at 20 min and 30 min, respectively. For the PN-films, the concentration of PNL influenced the mucoadhesive properties and tended to be higher when the amount of PNL increased. Immediate release of all blend film formulations was found in early time points(10–30 min). After 120 min, the release of PN-films-70 was lower than the other PNfilms. Permeation studies using porcine buccal mucosa showed that inclusion of nanoparticles in the films increased the permeability of PNL compared to PP-films. Therefore, buccal administration of mucoadhesive blend films containing PNL-loaded nanoparticles could be a promising approach for drugs that undergo first-pass metabolism. | Pakorn Kraisit Sontaya Limmatvapirat Manee Luangtana-Anan Pornsak Sriamornsak | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 1 |
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