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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘 | AGATHA C GEMMA L NURIA R | 1999 | Bichem Biophys Ras Commun1999，260，50： | 1 |
| 3 | Composites Reinforced in ThreeDimensions by Using Low Magnetic Fields显示文摘 | Randall ME Rafael L Nuria R | 2012 | Science2012，335，： | 1 |
| 4 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 5 | A signaling model of tgemporary layoffs显示文摘 | NURIA R P | 2009 | Oxford Economic Papers2009，61，3： | 1 |
| 6 | Prevention of radiochemotherapy-induced esophagitis with glutamine: results of a pilot study显示文摘 | Manuel A Nuria R Pedro V | 2007 | Int J Radiat Oncol Biol Phys2007，69，： | 1 |
| 7 | Penetrating 3D Imaging at 4 and 25 m Range Using a Submillimeter-Wave Radar显示文摘 | Cooper K B Dengler R J Nuria L | | 0，，12： | 1 |
| 8 | IBQS: A synthetic index of soil quality based on soil macro-invertebrate communi- ties显示文摘 | Nuria R Jerome M Leonide C | 2011 | Soil Biology and Biochemistry2011，43，10： | 1 |
| 9 | Eukaryotic elongation factor 2 controls TNF-[alpha] translation in LPS-induced hepatitis显示文摘 | González-Terán Bárbara Cortés José R Manieri Elisa Matesanz Nuria Verdugo ángeles Rodríguez María E González-Rodríguez águeda Valverde ángela Martín Pilar Davis Roger J Sabio Guadalupe | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 10 | IBQS:A synthetic index of soil quality based on soil macro-invertebrate communities显示文摘 | Nuria R Jér?me M Léonide C Christine R Gérard H Etienne I Patrick L | | 0，，： | 1 |
| 11 | lnhibiton of human P450 enzeymes by natural extracts used in traditional medicine 显示文摘 | IDANIA R MARIA TD NURIA J | 2009 | Phytother Res2009，23，2： | 1 |
| 12 | Production of ome ga-3 polyunsaturated fatty acid concentrates: a review 显示文摘 | Nuria R R Sagrario B Isabel J | 2010 | Innovative Food Science and Emerging Technolo gies2010，11，1： | 1 |
| 13 | THz Imaging Radar for Standoff Personnel Screening显示文摘 | Cooper K B Dengler R J Nuria L | | 0，，01： | 1 |
| 14 | Hysteroscopy in Pregnancy-Related Conditions: Descriptive Analysis in 273 Patients显示文摘 | Tirso Pérez-Medina Javier Sancho-Saúco Mar Ríos Augusto Pereira Nuria Argila Elena Cabezas Enrique Cayuela | 2013 | The Journal of Minimally Invasive Gynecology2013，，： | 1 |
| 15 | Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘 | Agatha C Gemma L Nuria R | 1999 | Bichem Biophys Ras Commun1999，260，50： | 1 |
| 16 | Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin 显示文摘 | MARTA V M ELISEO R NURIA A | 2007 | Chemistry & Biology2007，14，3： | 1 |
| 17 | Supercritical fluid extraction of fish oil from fish by-products : A comparison with other extraction methods 显示文摘 | NURIA R SARA M DIEGO D | 2012 | Journal of Food Engineering2012，，109： | 1 |
| 18 | Daytime sleepiness and polysomnography in obstructive sleep apnea patients显示文摘 | Nuria R Silvia G Olga M | 2008 | Sleep Med2008，9，7： | 1 |
| 19 | IBQS: A synthetic index of soil quality based on soil macro-invertebrate communities 显示文摘 | Nuria R J6r6me M L6onide C | 2011 | Soil Biology and Biochemistry2011，43，10： | 1 |
| 20 | Two new actions of topiranate:inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance显示文摘 | Ana I H Nuria D O Jose R G | 2002 | Neuropharmacology2002，4，： | 1 |
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