|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeted therapies in gastric cancer and future perspectives显示文摘Advanced gastric cancer(AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research has focused on the new treatment options for AGC. In the last two decades, many targeted molecules were developed against AGC. Currently, two targeted therapy molecules have been approved for patients with AGC. In 2010, trastuzumab was the first molecule shown to improve survival in patients with HER2-positive AGC as part of a first-line combination regimen. In 2014, ramucirumab was the second targeted molecule to improve survival rates and was suggested as treatment for patients with AGC who had progressed after firstline platinum plus fluoropyrimidine with or without anthracycline chemotherapy. Ramucirumab was the first targeted therapy acting as a single agent in patients with advanced gastroesophageal cancers. Although these two molecules were introduced into clinical use, many other promising molecules have been tested in phase Ⅰ-Ⅱ trials. It is obvious that in the near future many different targeted therapies will be in use for treatment of AGC. In this review, the current status of targeted therapies in the treatment of AGC and gastroesophageal junction tumors, including HER(2-3) inhibitors, epidermal growth factor receptor inhibitors, tyrosine kinase inhibitors, antiangiogenic agents, c-MET inhibitors, mammalian target of rapamycin inhibitors, agents against other molecular pathways fibroblast growth factor, Claudins, insulin-like growth factor, heat shock proteins, and immunotherapy, will be discussed. | Ozan Yazici M Ali Nahit Sendur Nuriye Ozdemir Sercan Aksoy | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 2 | Hepatic osteodystrophy and liver cirrhosis显示文摘AIM: To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis. METHODS: Bone mineral density of the patients (n = 55) and that of the control group (n = 30) were measured by dual-energy X-ray absorptiometry. All the women in the study were premenopausal. Deoxypyridinoline, pyridinoline and urinary Ca 2+ were measured as bone destruction markers, while alkaline phosphatase (ALP), osteocalcin and insulin-like growth factor-1 (IGF-1) were measured as bone formation markers. Furthermore, interleukin-1 (IL-1), IL-6, tumor necrosis factor α (TNF-α), vitamin D3, direct bilirubin, albumin, cortisol and parathyroid hormone (PTH) levels were measured. The independent Student t test and χ 2 test were employed in comparing both groups, and the Pearson correlation test was used to determine associations. RESULTS: Comparing cirrhosis and control groups, lumbar total T-score (-1.6 ± 1.2 g/cm 2 vs -0.25 ± 1.3 g/cm 2 , P < 0.001), lumbar total Z-score (-1.2 ± 1.23 g/cm 2 vs -0.6 ± 1.3 g/cm 2 , P < 0.001), total femur T-score (-0.05 ± 1 g/cm 2 vs -0.6 ± 0.9 g/cm 2 , P = 0.003) and total femur Z-score (-0.08 ± 1.5 g/cm 2 vs 0.7 ± 0.9 g/cm 2 , P =0.003) showed significantly lower values in the cirrhosis group. Blood ALP level (109.2 ± 57 U/Lvs 62.6 ± 32.5 U/L, P < 0.001), IL-6 level (27.9 ± 51.6 pg/mL vs 3.3 ± 3.1 pg/mL, P = 0.01), TNF-α level (42.6 ± 33.2 pg/mL vs 25.3 ± 12.3 pg/mL, P = 0.007) and direct bilirubin level (0.9 ± 0.7 mg/dL vs 0.3 ± 0.2 mg/dL, P < 0.001) were significantly higher in the cirrhosis group. IGF-1 level (47.7 ± 26.2 ng/mL vs 143.4 ± 53.2 ng/mL, P < 0.001), osteocalcin level (1.05 ± 2.5 ng/mL vs 7.0 ± 13 ng/mL, P = 0.002) and 24 h urinary Ca 2+ (169.6 ± 227.2 mg/dL vs 287 ± 168.6 mg/dL, P = 0.003) were significantly lower in the cirrhosis group. Urinary deoxypyridinoline/creatinine (9.4 ± 9.9 pmol/μmol vs 8.1 ± 5.3 pmol/μmol, P = 0.51), urinary pyridinoline/creatinine (51.3 ± 66.6 pmol/μmol vs 29 ± 25.8 pmol/μmol, P = 0.08), blood IL-1 level (3.4 ± 8.8 pg/mL vs 1.6 ± 3.5 pg/mL, P = 0.29), vitamin D3 level (18.6 ± 13.3 μg/L vs 18.4 ± 8.9 μg/L, P = 0.95), cortisol level (11.1 ± 4.8 μg/dL vs 12.6 ± 4.3 μg/dL, P = 0.15) and PTH level (42.7 ± 38 μg/dL vs 34.8 ± 10.9 μg/dL,P = 0.27) were not significantly different. CONCLUSION: Hepatic osteodystrophy is an important complication encountered in patients with liver cirrhosis and all patients should be monitored for hepatic osteodystrophy. | Vedat Goral Mehmet Simsek Nuriye Mete | 2010 | World Journal of Gastroenterology2010，16，13： | 11 |
| 3 | Immediate postabortal contraception with the levonorgestrel intrauterine device, Norplant, and traditional methods显示文摘 | Nuriye Ortayli Aysen Bulut Tulay Sahin | 2001 | Contraception2001，63，： | 1 |
| 4 | Magnetic resonance spectroscopic imaging associated with analysis of fluid in cystic brain tumors显示文摘 | Alaattin Yurt Nuriye Demircan Mehmet SelcCuki | 2010 | Neurological Research2010，32，2： | 1 |
| 5 | The Use of Voltammetry for Sorption Studies of Pb 2+ from Aqueous Media using Schiff Base Immobilized Biologic Polymer Material显示文摘 | Semahat Kucukkolbasi Zehra ?zden Erdo?an Nuriye Kocak Mustafa Sahin Ilkay Hilal Gubbuk | 2013 | Water, Air, & Soil Pollution2013，，3： | 1 |
| 6 | Implications for Degenerative Disorders: Antioxidative Activity, Total Phenols, Flavonoids, Ascorbic Acid, β-Carotene and β-Tocopherol in Aloe vera显示文摘 | Nurten Ozsoy Eda Candoken Nuriye Akev | 2009 | Oxidative Medicine and Cellular Longevity2009，，2： | 1 |
| 7 | Frequency of gestational diabetes mel- litus and the associated risk factors 显示文摘 | Nuriye Buyukkayaci Duman | 2015 | Pak J Med Sci2015，31，1： | 1 |
| 8 | Effectiveness of foot and hand massage in postc- esarean pain control in a group of Turkish pregnant women显示文摘 | Nuriye Degirmen | 2011 | Applied Nursing Research2011，24，2： | 1 |
| 9 | Synthesis of crosslinked chitosan possessing schiff base and its use in metal removal显示文摘 | Nuriye K Mustafa S Gulsin A | 2012 | J Inorg Organomet Polym2012，22，： | 1 |
| 10 | Evaluation of the effect of comorbidity on survival in pancreatic cancer by using “Charlson Comorbidity Index” and “Cumulative Illness Rating Scale”显示文摘 | F. Tugba Kos Ozan Yazici Burak Civelek Metin Seker Zafer Arik Sercan Aksoy Dogan Uncu Nuriye Ozdemir Nurullah Zengin | 2014 | Wiener klinische Wochenschrift . 2014 (1-2)2014，，1： | 1 |
| 11 | Strategic environmental assessment and national development plans in Turkey:Towards legal framework and operational procedure显示文摘 | Muzaffer Yucel | 2006 | Environmental Impact Assessment Review2006，，26： | 1 |
| 12 | Strategic environmental assessment and national development plans in Turkey : Towards legal framework and operational procedure 显示文摘 | Nuriye Peker Say Muzaffer Yucel | 2006 | Environmental Impact Assessment Review2006，26，： | 1 |
| 13 | Strategic environmental assessment and national development plans in Turkey : Towards legal framework and operational procedure显示文摘 | NURIYE PEKER SAY MUZAFFER YIICEL | 2006 | Environmental Impact Assessment Review2006，，26： | 1 |
| 14 | Is exon mutation analysis needed for adjuvant treatment of gastrointestinal stromal tumor?显示文摘Gastrointestinal stromal tumors(GISTs) are the most common soft tissue sarcoma of the gastrointestinal tract,resulting from an activating mutation of stem cell factor receptor(KIT),and an activating mutation of the homologous platelet-derived growth factor receptor alpha(PDGFRA) kinase.Most GISTs(90%-95%) are KIT-positive.About 5% of GISTs are truly negative for KIT expression.GISTs have been documented to resistant conventional chemotherapeutics.Due to the KIT activation that occurs in the majority of the cases,KIT inhibition is the primary treatment approach in the adjuvant treatment of metastatic GISTs.Imatinib mesylate is an oral agent that is a selective protein tyrosine kinase inhibitor of the KIT protein tyrosine kinase,and it has demonstrated clinical benefit and objective tumor responses in most GIST patients in phase Ⅱ and Ⅲ trials.The presence and the type of KIT or PDGFRA mutation are predictive of response to imatinib therapy in patients with advanced and metastatic disease.Molecular analysis in phaseⅠ-Ⅱ trials revealed significant differences in objective response,progression-free survival,and overall survival between GISTs with different kinase mutations.The aim of this letter is to touch on the need for exon mutation analysis for adjuvant treatment with imatinib in GIST patients. | Mehmet Ali Nahit Sendur Nuriye Yildirim zdemir Muhammed Bülent Akinci Dogan Uncu Nurullah Zengin Sercan Aksoy | 2013 | World Journal of Gastroenterology2013，19，1： | 1 |
| 15 | Effects of Aloe vera leaf gel extract on rat peritonitis model显示文摘 | Ayca Altincik Ferah S?nmez ?igdem Yenisey Soner Duman Ayse Can Nuriye Akev Sevin Kirdar Murat Sezak | 2014 | Indian Journal of Pharmacology2014，，3： | 1 |
| 16 | Living the Mechanical Dream显示文摘Studying in China is not just about academics,it is also about connecting with communities and learning local culture.As a child,I was captivated by machines and their inner workings.I yearned to design contraptions that could solve real-world problems and improve people’s lives.So,when it came time to choose a university,I knew that mechanical engineering was the path for me. | KEDIR ABDUREZAK NURIYE | 2024 | ChinAfrica2024，16，3： | 0 |
| 17 | edia Sources for Seeking Health Information in Women显示文摘 | Gulay Yilmazel A. Burcu Akbulut Nuriye Buyukkayaci Duman | 2013 | 通讯和计算机(中英文版)2013，10，7： | 0 |
| 18 | Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma显示文摘Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma(PAC).Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.Results: Of 563 patients, 472 received adjuvant chemotherapy(CT) alone, chemoradiotherapy(CRT) alone, and chemoradiotherapy plus chemotherapy(CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival(RFS) and overall survival(OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were considered.Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection. | Nedim Turan Mustafa Benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül Babacan Gulnihal Tufan Zuhat Urakci Basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem Balvan Ercelep Burcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber | 2015 | Chinese Journal of Cancer Research2015，27，4： | 0 |
| 19 | Knowledge of reproductive health rights and its associated factors among Wolkite University undergraduate students, Wolkite, southern Ethiopia显示文摘Objective:Reproductive health(RH)rights are the rights of all persons,regardless of age,sex,or other traits,and they have the freedom to make decisions about their sexuality and RH.However,there is limited information about Ethiopians’understanding of RH rights.Because little is known about the degree of knowledge and relevant predictors in the study area,this study was carried out to fill in the gaps.Methods:An institution-based cross-sectional study was conducted from 3 January to 25 January 2021 G.C to determine the knowledge level of RH rights and its associated factors among Wolkite University undergraduate medical students.The minimum estimated sample size was computed by using the simple population proportion formula of 95%confidence interval(CI),with 5%of marginal error,which was 318 students.The students were stratified based on their academic year and department.Each student was selected from each department by using the simple random sampling method based on their ID numbers.Data were collected by using a pre-tested,structured self-administered questionnaire.Epi Info version 3.5.1 was used for data coding,entering,and cleaning,and then the data were expor ted to Statistical Package for Social Sciences(SPSS)version 23 for advanced analysis.The associated factors were identified by performing analysis for bivariate and multivariate logistic regression analyses.Results:More than half(56.33%)of the par ticipants were knowledgeable about reproductive and sexual rights and par ticipated in RH clubs(adjusted odds ratio[AOR]:2.94,95%CI:1.46,5.91).The paternal educational level(AOR:2.89,95%CI:1.34,5.65)had an association with the knowledge of reproductive health rights.Conclusions:The students’knowledge regarding reproductive and sexual rights was found to be little.The Ethiopia Ministry of Education has to include reproductive and sexual rights in the curriculum of high school and higher institution studies. | Seid Jemal Mohammed Eskindir Demisie Zergaw Kenzudin Assfa Mosaa Keyredin Nuriye Mossa Yibeltal Mesfin Yesgat | 2022 | Frontiers of Nursing2022，9，4： | 0 |
| 20 | V5VIRE EN CHZNE显示文摘RECITS D'EXPERIENCES VECUES PAR DES AFRICAINS INSTALLES EN CHINE Etudiant ethiopien a I'Universite des sciences et technologies electroniques de Chine,Chengdu,province du Sichuan Les mecanismes d'un reve Voyage d'un etudiant en ingenierie entre deux mondes Des mon plus jeune age,j'aiéte fascine par les machines et leur mecanisme interne.Mon reveétait de creer des dispositifs capables de résoudre des problemes concrets et d'ameliorer le quotidien des individus.Lorsqu'il a fallu choisir mon parcours universitaire. | KEDIR ABDUREZAK NURIYE | 2024 | 中国与非洲(法文版)2024，16，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员