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46篇 您的检索式：作者名="Nutten"

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	题名	作者	年代	出处	被引量
1	Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential.	Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot	2007	World Journal of Gastroenterology2007，13，2：	22
2	From the cover: enhanced antiinflammatory capacity of a lactobacillus plantarum mutant synthesizing modified teichoie acids 显示文摘	Grangette C Nutten S Palumbo E	2005	PNAS2005，102，10：	1
3	Schistosoma mansoni schistosomula reduce E-selectin and VCAM-I expression in TNF- alpha-stimulated lung microvascular endothelial cells by interfering with the NF-kappaB pathway 显示文摘	Trottein F Nutten S Angeli V	1999	Eur J Immunol1999，29，：	1
4	Pregnancy induced hypertension in women with gestational carbohydrate intolerance:the diagest study显示文摘	Vambergue A Nuttens MC Goeusse P		0，，01：	1
5	Pregnancy induced hypertension in women with gestational carbohydrate intolerance:the diagest study显示文摘	Vambergue A Nuttens MC Goeusse P	2002	Eur J Obstet Gynecol Reprod Biol2002，102，1：	1
6	The micro and semi- micro determination of alkoxyl groups 显示文摘	Belcher R Fildes J E Nutten A J	1955	Analytica Chimica Acta1955，13，：	1
7	Attenuation of colon inflammation through activators of the rethinoid x receptor (RXR)/peroxisome proliferator-activated receptor γ(PPARγ) heterodimer:a basis for new therapeutic strategies显示文摘	DESREUMAUX P DUBUQUOY L NUTTEN S	2001	J Exp Med2001，193，：	1
8	Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids显示文摘	GRANGETTE C NUTTEN S PALUMBO E	2005	Proceedings of the National Academy of Sciences of the United States of America2005，102，10：	1
9	A new optical instru-ment for simultaneous measurements of raindrop diameter and falldistribution 显示文摘	Hauser D Amayenc P Nutten P	1984	Journal of Atmospheric and Oceanic Technology1984，1，：	1
10	Pregnancy inducer! hypertension in women with gestational carbohydrate intolerance:the digest study显示文摘	Vamhergue A Nuttens MC Goeusse P	2002	Eur J Obstet Gynecol Reprod Biol2002，102，1：	1
11	Pregnancy induced hypertension in women with gestation carbohydrate intolerance显示文摘	Vambergue A Nuttens MC Goeusse P	2002	Eur J Obstet Gynecol Reprod Biol2002，102，：	1
12	Pregnancy induced hypertension in women with gestational carbohydrate intolerance: the diagnosis study 显示文摘	Vambergue A Nuttens MC	2002	E J Obstet Gynecol Reprod Biol2002，102，1：	1
13	Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats显示文摘	García-Ródenas CL Bergonzelli GE Nutten S	2006	J Pediatr Gastroenterol Nutr2006，43，1：	1
14	Schistosoma mansoni schistosomula reduce E-selectin and VCAM-1 expression in TNF- alpha-stimulated lung microvascular endothelial cells by interfering with the NF-Kappa B pathway显示文摘	Trottein F Nutten S Anqeli V	1999	Eur J Immunol1999，29，11：	1
15	Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects 显示文摘	Folign B Nutten S Steidler L	2006	Dig Dis Sci2006，51，2：	1
16	Pregnancy-induced hypertension in women with gestational carbohydrate intolerance显示文摘	Vambergue A Nuttens MC Goeusse P	2002	Eur J Obstet Gynecol Reprod Biol2002，102，1：	1
17	Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases显示文摘	Dubuquoy L Dharancy S Nutten S		0，，：	1
18	Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype显示文摘	Trottein F Descamps L Nutten S	1999	Infection and Immunity1999，67，7：	1
19	Enhanced antiinflammatory capacity of a LactobaciUus plantarum mutant synthesizing modified teichoic acids 显示文摘	GRANGETTE C NUTTEN S PALUMBO E	2005	Proceedings of the National Academy of Sciences of the United States of America2005，102，10：	1
20	Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroentemlogical diseases显示文摘	Dubuquoy L Dharancy S Nutten S		0，，：	1

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