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| 1 | Rosmarinic acid ameliorates hypoxia/ischemia induced cognitive deficits and promotes remyelination显示文摘Rosmarinic acid,a common ester extracted from Rosemary,Perilla frutescens,and Salvia miltiorrhiza Bunge,has been shown to have protective effects against various diseases.This is an investigation into whether rosmarinic acid can also affect the changes of white matter fibers and cognitive deficits caused by hypoxic injury.The right common carotid artery of 3-day-old rats was ligated for 2 hours.The rats were then prewarmed in a plastic container with holes in the lid,which was placed in 37°C water bath for 30 minutes.Afterwards,the rats were exposed to an atmosphere with 8% O2 and 92% N2 for 30 minutes to establish the perinatal hypoxia/ischemia injury models.The rat models were intraperitoneally injected with rosmarinic acid 20 mg/kg for 5 consecutive days.At 22 days after birth,rosmarinic acid was found to improve motor,anxiety,learning and spatial memory impairments induced by hypoxia/ischemia injury.Furthermore,rosmarinic acid promoted the proliferation of oligodendrocyte progenitor cells in the subventricular zone.After hypoxia/ischemia injury,rosmarinic acid reversed to some extent the downregulation of myelin basic protein and the loss of myelin sheath in the corpus callosum of white matter structure.Rosmarinic acid partially slowed down the expression of oligodendrocyte marker Olig2 and myelin basic protein and the increase of oligodendrocyte apoptosis marker inhibitors of DNA binding 2.These data indicate that rosmarinic acid ameliorated the cognitive dysfunction after perinatal hypoxia/ischemia injury by improving remyelination in corpus callosum.This study was approved by the Animal Experimental Ethics Committee of Xuzhou Medical University,China (approval No.20161636721) on September 16,2017. | Man Li Miao-Miao Cui Nwobodo Alexander Kenechukwu Yi-Wei Gu Yu-Lin Chen Si-Jing Zhong Yu-Ting Gao Xue-Yan Cao Li Wang Fu-Min Liu Xiang-Ru Wen | 2020 | Neural Regeneration Research2020，15，5： | 3 |
| 2 | Long term effect of municipal waste disposal on soil properties and productivity of sites used for urban agriculture in Abakaliki, Nigeria显示文摘 | M.A.N Anikwe K.C.A Nwobodo | 2002 | Bioresource Technology2002，，3： | 2 |
| 3 | Long term effect of municipal waste disposal on soil properties and productivity of sites used for urban agriculture in Abakaliki, Nigeria 显示文摘 | Anikwe M A N Nwobodo K C A | 2002 | Bioresource Technology2002，3，3： | 1 |
| 4 | Medical students evaluation of physiology learning environments in two Nige- rian medical schools,Teaching of the renal system in an in- tegrated, problem -based curriculum 显示文摘 | Anyaehie USB Nwobodo E Oze G | 2011 | Adv Physiol Educ2011，，35： | 1 |
| 5 | Hypochotesterolemic effects of crude extract of leaf of Moringa Oleifera Lain in high-fat diet fed wistar rats显示文摘 | Ghasi S Nwobodo E Ofili J O | 2000 | Journal of Ethnopharmacology2000，69，1： | 1 |
| 6 | Hypocholesterolemic effects of crude extract of leaf of Mormga oleifera Lam in high-fat diet fed wistar rats显示文摘 | Ghasi S Nwobodo EN Of′tli JO | 2000 | J Ethnopharrnacol2000，69，1： | 1 |
| 7 | Hypocholes terolemic effects of crude extract of leaf of Monnga oleera Lam in high-fat diet fed wistar rats 显示文摘 | Ghasi S Nwobodo E Ofili J O | 2000 | Journal of Ethnopharmacology2000，69，1： | 1 |
| 8 | Hypochotesterolemic effects of crude extract of leafof Moringa oleifera Lam in high-fat diet fed wistar rats显示文摘 | GHASI S NWOBODO E OFILI J O | 2000 | Journal Ethnophannacology2000，69，1： | 1 |
| 9 | Ruptured uterus in a booked patient显示文摘 | Isah AY Nwobodo EI Tunau KA | | 0，，04： | 1 |
| 10 | Hyptocholesterolemic effects of crude extract of leaf ofMoringa oleifera Lain in high fat diet fed Wistar rats显示文摘 | Ghasi S Nwobodo E Ofili JO | 2000 | J Ethnopharmacol2000，69，1： | 1 |
| 11 | Abdominal pregnancy: A case report 显示文摘 | Nwobodo E I | 2004 | Ann Afr Med2004，3，4： | 1 |
| 12 | Emergency obstetric hysterectomy in a tertiary hospital in sokoto,Nigeria显示文摘 | Nwobodo E Nnadi D | 2012 | Ann Med Health Sci Res2012，2，1： | 1 |
| 13 | Long term effect of municipal waste disposal on soil properties and productivity of sites used hr urban agriculture in Abakaliki, Nigeria 显示文摘 | Anikwe M A N Nwobodo K C A | 2002 | Bioresource Technology2002，83，3： | 1 |
| 14 | Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistarrats 显示文摘 | E Nwobodo J O Ofili | 2000 | JournalofEthnopharmacology2000，69，： | 1 |
| 15 | Long term effect of municipal waste disposal on soil properties and productivity of sites used for urban agriculture in Abakaliki, Nigeria显示文摘 | Anikwe MAN Nwobodo KCA | 2002 | Bioresource Technology2002，83，： | 1 |
| 16 | Hypocholest erolemic effect s of crude extract of leaf of Moringa oleifera Lam in high- fat diet fed wistar rats显示文摘 | Ghasi S Nwobodo E Ofili JO | 2000 | J Et hnophar -macol2000，69，1： | 1 |
| 17 | Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats显示文摘 | Ghasi S Nwobodo E Ofili JO | 2000 | J Ethnophar?macal2000，69，1： | 1 |
| 18 | Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats显示文摘 | Ghasi S Nwobodo E Ofili J O | 2000 | Journal of Ethnopharmacology2000，69，1： | 1 |
| 19 | Medical students' evaluation of physiology learning environments in two Nigerian medical schools 显示文摘 | Anyaehie US Nwobodo E Oze G | 2011 | Adv Physiol Educ2011，35，2： | 1 |
| 20 | Long term effect of municipalwaste disposal on soil properties and productivity of sites used forurban agriculture in Abakaliki, Nigeria显示文摘 | Anikwe MAN Nwobodo K C A | 2002 | Bioresource Technology2002，83，3： | 1 |
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