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| 1 | Large-scale experimental study of precast segmental unbonded posttensioned concrete bridge columns for seismic regions显示文摘 | Ou Yuchen Wang Pinghsiung Tsai Musen | 2010 | Journal of Structural Engineering ASCE2010，136，3： | 1 |
| 2 | Cyclic behavior of precast segmental concrete bridge columns with high performance or conventional steel reinforcing bars as energy dissipation bars显示文摘 | Ou Yuchen Tsai Musen Chang Kuochun | 2010 | Earthquake Engineer- ing and Structural Dynamics2010，39，11： | 1 |
| 3 | Long-term Seismic Performance of Reinforced Concrete Bridges Under Steel Reinforcement Corrosion Due to Chloride Attack显示文摘 | Ou Yuchen Fan Hongda Nguyen Dang Nguyen | 2013 | Earthquake Engng Struct Dyn2013，42，14： | 1 |
| 4 | Seismic perform- ance of segmental precast un-bonded post-tensioned concrete bridge column显示文摘 | Ou Yuchen Chiewanichakorn M | 2007 | Journal of Structural En- gineering2007，133，11： | 1 |
| 5 | Large- scale experimental study of precast segmental un- bonded post-tensioned concrete bridge columns for seismic regions 显示文摘 | Ou Yuchen Wang Pingsiu Tsai Musen | 2010 | Journal of Structural Engineer- ing2010，136，3： | 1 |
| 6 | Cyclic behavior of precast segmental concrete bridge columns with high performance or conventional steel reinforcing bars as energy dissipation bars显示文摘 | Ou Yuchen Tsai M S Chang Kuochun | 2010 | Earthquake Engineering and Structural Dynamics2010，39，11： | 1 |
| 7 | Large-scale experimental study of precast segmental unbonded posttensioned concrete bridge columns for seismic regions显示文摘 | Ou Yuchen Wang Pingsiu Tsai Musen | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 8 | Seismic per- formance of segmental precast unbonded post- tensioned concrete bridge column 显示文摘 | Ou Yuchen Chiewanichakorn M | 2007 | Journal of Structural Engineering ASCE2007，133，11： | 1 |
| 9 | Large-scale experimental study of precast seg- mental unbonded post-tensioned concrete bridge columns for seismic regions 显示文摘 | Ou Yuchen Wang Pingsiu Tsai Musen | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 10 | Cyclic Behavior of Precast Segmental Concrete Bridge Col- umns with High Performance or Conventional Steel Reinforcing Bars as Energy Dissipation Bars 显示文摘 | OU Yuchen TSAI Musen CHANG Kuochun | 2010 | Earthquake Engineering and Structural Dynamics2010，39，11： | 1 |
| 11 | Large-Scale Experimental Study of Precast Segmental Un- bonded Posttensioned Concrete Bridge Columns for Seismic Regions 显示文摘 | OU Yuchen WANG Pinghsiung TSAI Musen | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 12 | Lee Large-Scale Experimental Study of Precast Segmental Unbonded Postt- ensioned Concrete Bridge Columns for Seismic Regions 显示文摘 | Ou YuChen Wang Pinghsiung Tsai Musen | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 13 | Seismic perform- ance of segmental precast un-bonded post-tensioned concrete bridge columns 显示文摘 | Ou Yuchen Chiewanichakorn M | 2007 | Journal of Structural Engineering ASCE2007，133，11： | 1 |
| 14 | Cy- clic behavior of precast segmental concrete bridge columns with high performance or conventional steel reinforcing bars as energy dissipation bars 显示文摘 | Ou Yuchen Tsai Musen Chang Kuochun | 2010 | Earth- quake Engineering and Structural Dynamics2010，39，11： | 1 |
| 15 | Cyclic performance of large-scale corroded reinforced concrete beams 显示文摘 | OU Yuchen TSA1 Lilan CHEN Houheng | 2012 | Earthquake Engineering andStructural Dynamics2012，41，： | 1 |
| 16 | Large-scale experimental study of precast segmental un-bonded post-tensioned concrete bridge columns for seismic regions 显示文摘 | Ou Yuchen Wang Pinghsiung Tsai Musen | 2010 | Journal of Structural Engi- neering2010，136，3： | 1 |
| 17 | Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function显示文摘Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment. | Zhen Xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu Siyi Xu Tianbin Chen Jing Chen Qishui Ou | 2021 | Cellular & Molecular Immunology2021，18，2： | 1 |
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