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| 1 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 2 | Big Earth Data science:an information framework for a sustainable planet显示文摘The digital transformation of our society coupled with the increasing exploitation of natural resources makes sustainability challenges more complex and dynamic than ever before.These changes will unlikely stop or even decelerate in the near future.There is an urgent need for a new scientific approach and an advanced form of evidence-based decisionmaking towards the benefit of society,the economy,and the environment.To understand the impacts and interrelationships between humans as a society and natural Earth system processes,we propose a new engineering discipline,Big Earth Data science.This science is called to provide the methodologies and tools to generate knowledge from diverse,numerous,and complex data sources necessary to ensure a sustainable human society essential for the preservation of planet Earth.Big Earth Data science aims at utilizing data from Earth observation and social sensing and develop theories for understanding the mechanisms of how such a social-physical system operates and evolves.The manuscript introduces the universe of discourse characterizing this new science,its foundational paradigms and methodologies,and a possible technological framework to be implemented by applying an ecosystem approach.CASEarth and GEOSS are presented as examples of international implementation attempts.Conclusions discuss important challenges and collaboration opportunities. | Huadong Guo Stefano Nativi Dong Liang Max Craglia Lizhe Wang Sven Schade Christina Corban Guojin He Martino Pesaresi Jianhui Li Zeeshan Shirazi Jie Liu Alessandro Annoni | 2020 | International Journal of Digital Earth2020，13，7： | 12 |
| 3 | Recent Advances in Hydrometallation of Alkenes and Alkynes via the First Row Transition Metal Catalysis显示文摘Hydrometallation of alkenes and alkynes provides a straightforward route to access alkyl- or alkenyl-metal reagents, which have a wide rangeof applications in organic transformations. In recent years, the first row transition metals (such as copper, nickel, cobalt, iron, etc.) have emerged highactivity and selectivity in this area with the aid of a variety of ligands. This review covers the recent advances in the hydrometallation of minimally func-tionalized unsaturated C--C bonds (including alkenes, alkynes, dienes, allenes, enynes, etc.), as well as transformations involving catalytic hydrometalla-tion process via the first row transition metal catalysis. | Jianhui Chen Jun Guo Zhan Lu | 2018 | Chinese Journal of Chemistry2018，36，11： | 12 |
| 4 | Non-Darcy flow in oil accumulation (oil displacing water) and relative permeability and oil saturation characteristics of low-permeability sandstones显示文摘Hydrocarbon resources in low-permeability sandstones are very abundant and are extensively distributed. Low-permeability reservoirs show several unique characteristics,including lack of a defi nite trap boundary or caprock,limited buoyancy effect,complex oil-gas-water distribution,without obvious oil-gas-water interfaces,and relatively low oil(gas) saturation. Based on the simulation experiments of oil accumulation in low-permeability sandstone(oil displacing water) ,we study the migration and accumulation characteristics of non-Darcy oil flow,and discuss the values and influencing factors of relative permeability which is a key parameter characterizing oil migration and accumulation in low-permeability sandstone. The results indicate that:1) Oil migration(oil displacing water) in lowpermeability sandstone shows non-Darcy percolation characteristics,and there is a threshold pressure gradient during oil migration and accumulation,which has a good negative correlation with permeability and apparent fluidity;2) With decrease of permeability and apparent fluidity and increase of fluid viscosity,the percolation curve is closer to the pressure gradient axis and the threshold pressure gradient increases. When the apparent fluidity is more than 1.0,the percolation curve shows modifi ed Darcy flow characteristics,while when the apparent fluidity is less than 1.0,the percolation curve is a 'concaveup' non-Darcy percolation curve;3) Oil-water two-phase relative permeability is affected by core permeability,fluid viscosity,apparent fluidity,and injection drive force;4) The oil saturation of lowpermeability sandstone reservoirs is mostly within 35%-60%,and the oil saturation also has a good positive correlation with the permeability and apparent fluidity. | Zeng Jianhui Cheng Shiwei Kong Xu Guo Kai Wang Hongyu | 2010 | Petroleum Science2010，7，1： | 11 |
| 5 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://wheatomics.sdau.edu.cn/,previously designated as Triticeae Multi-omics Center,http://202.194.139.32/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 6 | Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period显示文摘Background:Early pregnancy failure has a profound impact on both human reproductive health and animal production.2/3 pregnancy failures occur during the peri-implantation period;however,the underlying mechanism(s)remains unclear.Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy.Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.Result:In this study,using well-managed recipient ewes that received embryo transfer as model,we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period.After embryo transfer,recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy.By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes,we identified 94 and 257 differentially expressed proteins(DEPs) in the endometrial caruncular and intercaruncular areas,respectively.Functional analysis showed that the DEPs were mainly associated with immune response,nutrient transport and utilization,as well as proteasome-mediated proteolysis.Conclusion:These analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss.In addition,many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes.These proteins,as potential candidates,may contribute to early pregnancy loss. | Haichao Zhao Linlin Sui Kai Miao Lei An Dong Wang Zhuocheng Hou Rui Wang Min Guo Zhilong Wang Jiqiang Xu Zhonghong Wu Jianhui Tian | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 8 |
| 7 | Hydrodynamic Evolution and Hydrocarbon Accumulation in the Dabashan Foreland Thrust Belt,China显示文摘在 Dabashan 低岬有二出戏构造的带:上面并且更低的戏。更低的戏经历了当上面的戏有一个沉积水动力学阶段时,水动力学从 Sinian 上演到新生代的一个沉积水动力学阶段,二个埋葬水动力学阶段,二个构造水动力学阶段和二渗入,一个埋葬水动力学阶段,二个构造水动力学阶段和阶段渗入水动力学阶段从对新生代二叠。两沉积的水,包括的烃,和深披风液体的广泛的流动在中间迟了的三叠纪的 Indosinian 造山运动在碰撞造山运动期间在 Chengkou 差错发生了,并且液体流动在在中间迟了的侏罗记的 intracontinental 造山运动期间是复杂的。除了这些运动,,大气的水的渗入和运动在封面阶层 decollement 发生在 Chengkou 差错构造的带,广泛的沉积的水流动(包括的烃) 主要在 Zhenba 和 Pingba 差错发生了。在阶段期间快速高举并且从白垩纪的发掘到新生代,液体流动主要被高度差别引起的大气的水和导致严肃的流动的渗入描绘,而构造过程引起的沉积的水流动是相对不太重要。沉积的水流动在在中间迟了的三叠纪的 Indosinian 造山运动的碰撞造山运动期间对在烃移植和累积的更低的戏更重要,但是它的影响在上面的戏上是相对细微的。一方面,水动力学在在中间迟了的侏罗记的 intracontinental 造山运动期间调整了,改革或炉破坏了在更低的戏的油水库;在另一方面,它驱使大量烃旁边地并且垂直地移居并且为烃累积是有利的。主要从白垩纪调整并且破坏油水库到新生代的渗入水动力学。 | ZENG Jianhui GUO Kai TIAN Kun XU Tianwu | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 8 | A universal elliptical disc(UED)model to represent natural rock fractures显示文摘Since natural fractures are often non-equidimensional,the circular disc model still has great limitations.By contrast,the elliptical disc model is more applicable to representing natural fractures,especially for slender ones.This paper developed a universal elliptical disc(UED)model by incorporating the center point,size,and azimuth of fractures as variables.Specifically,with respect to the azimuth of elliptical fractures in three-dimensional(3D)space,we proposed a paradigm to construct its probability density function(PDF)by coupling the orientation and rotation angle of long axis based on three coordinate transformations.To illustrate the construction process of the PDF of the fracture azimuth,we took the orientation following the Fisher distribution and the rotation angle following Von Mises distribution as an example.A rock slope is used to show the use of the developed UED model,and the 3D DFNs for the slope rock mass are generated by Monte Carlo simulation.In addition,the DFNs for the rock mass are also generated based on the existing circular disc model and non-universal elliptical disc model.The comparison results from the three models clearly illustrate the superiority of the UED model over the existing circular and non-universal elliptical disc models. | Jun Zheng Jichao Guo Jiongchao Wang Honglei Sun Jianhui Deng Qing Lv | 2022 | International Journal of Mining Science and Technology2022，32，2： | 4 |
| 9 | A grid-based clustering algorithm for wild bird distribution显示文摘 | Yuwei WANG Yuanchun ZHOU Ying LIU Ze LUO Danhuai GUO Jing SHAO Fei TAN Liang WU Jianhui LI Baoping YAN | 2013 | Frontiers of Computer Science2013，7，4： | 4 |
| 10 | On-line Popularity Monitoring Method Based on Bloom Filters and Hash tables for Differentiated Traffic显示文摘Towards line speed and accurateness on-line content popularity monitoring on Content Centric Networking(CCN) routers, we propose a three-stage scheme based on Bloom filters and hash tables for differentiated traffic. At the first stage, we decide whether to deliver the content to the next stage depending on traffic types. The second stage consisting of Standard Bloom filters(SBF) and Counting Bloom filters(CBF) identifies the popular content. Meanwhile, a scalable sliding time window based monitoring scheme for different traffic types is proposed to implement frequent and real-time updates by the change of popularities. Hash tables according with sliding window are used to record the popularity at the third stage. Simulation results reveal that this method reaches a 40 Gbps processing speed at lower error probability with less memory, and it is more sensitive to the change of popularity. Additionally, the architecture which can be implemented in CCN router is flexible and scalable. | ZHANG Guo ZHANG Jianhui WANG Binqiang ZHANG Zhen | 2016 | China Communications2016，13，S1： | 4 |
| 11 | Novel Implementation of Track-Oriented Multiple Hypothesis Tracking Algorithm显示文摘 | GUO Jianhui ZHANG Rongtao | 2012 | Chinese Journal of Electronics2012，21，4： | 3 |
| 12 | Rare Earth Luminescent Materials for White LED Solid State Lighting显示文摘Solid-state white LED will be a new generation of energy-saving light source in 21 century. In order to emitting white light, one of important approaches is using luminescence conversion technology with rare earth phosphors, which can be excited by the 460 nm blue light or 400 nm near violet light emitted from the InGaN chip and then emit white light. The rare earths doped phosphors prepared by us such as YAG∶Ce 3+, Ca 1-xSrxS∶Eu 2+, Ga2S3∶Eu 2+, MGa2S4∶Eu 2+(M=Ca, Sr, Ba), SrGa 2+xS 4+y∶Eu 2+, (Ca 1-xSrx)Se∶Eu 2+, SrLaGa3S6O∶Eu 2+, (M1, M2) 10(PO4)6X2 (M1=Ca, Sr, Ba; M2=Eu, Mn; X=F, Cl, Br) and NaEu 0.92Sm 0.08(MoO4)2 were reported. They emit blue, green, yellow or red color light. Some white LEDs were made by these phosphors with blue or near violet InGaN chips and their chromaticity coordinate (x, y), correlated color temperature TC, and color rendering index Ra are reported. | Su Qiang Wu Hao Pan Yuexiao Xu Jian Guo Chongfeng Zhang Xinmin Zhang Jianhui Wang Jing Zhang Mei | 2005 | Journal of Rare Earths2005，23，5： | 3 |
| 13 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 14 | Extended Sufficient Conditions for Exact Relaxation of the Complementarity Constraints in Storage-concerned Economic Dispatch显示文摘Storage is widely considered in economic dispatch(ED)problems.To prevent simultaneous charging and discharging of a storage device,a storage-concerned ED problem should involve complementarity constraints for every storage device to make the problem strongly non-convex.In this case,the conventional Karush-Kuhn-Tucker optimality conditions are unsuitable,and the methods that are normally effective are also invalid.In our recent paper,we proposed a new exact relaxation method that directly removes the complementarity constraints from a storageconcerned ED model to make it convex and easy to solve.This paper extends the previous study by presenting and analyzing two new groups of sufficient conditions that guarantee exact relaxation.Different application conditions of these groups of sufficient conditions are discussed.Numerical tests are performed to show the benefit of using the exact relaxation method and the different suitable application conditions of these groups of sufficient conditions.This paper contributes to a wide application of exact relaxation in storage-concerned ED problems. | Zhengshuo Li Qinglai Guo Hongbin Sun Jianhui Wang | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 3 |
| 15 | System resilience enhancement: Smart grid and beyond显示文摘Boosting the resilience of power systems is a core requirement of smart grids. In fact, resilience enhancement is crucial to all critical infrastructure systems.In this study, we review the current research on system resilience enhancement within and beyond smart grids. In addition, we elaborate on resilience definition and resilience quantification and discuss several challenges and opportunities for system resilience enhancement. This study aims to deepen our understanding of the concept of resilience and develop a wide perspective on enhancing the system resilience for critical infrastructures. | Gang HUANG Jianhui WANG Chen CHEN Chuangxin GUO Bingquan ZHU | 2017 | Frontiers of Engineering Management2017，4，3： | 2 |
| 16 | Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection显示文摘Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus DNA replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873 D infected with minute virus of canines(MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC DNA replication and reduce viral gene expression at both mRNA and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC infection.Furthermore, OMT significantly increased cell viability, decreased MVC-infected cell apoptosis, and reduced the expression of activated caspase 3. Our results suggest that OMT has potential application in combating parvovirus infection. | Yanqin Ding Na Li Jinhan Sun Linran Zhang Jianhui Guo Xueqi Hao Yuning Sun | 2019 | Virologica Sinica2019，34，1： | 2 |
| 17 | Flexible artificial synapse based on single-crystalline BiFeO_(3) thin film显示文摘Realization of functional flexible artificial synapse is a significant step toward neuromorphic computing.Herein,a flexible artificial synapse based on ferroelectric tunnel junctions(FTJs)is demonstrated,using BiFeO_(3)(BFO)thin film as the functional layer.The inorganic single crystalline FTJs grown on rigid perovskite substrates at high temperatures are integrated with the flexible plastic substrates,by using the water-soluble Sr_(3)Al_(2)O_(6)(SAO)as the sacrificial layer and the following transfer.The transferred freestanding BFO thin film exhibits excellent ferroelectric properties.Moreover,the memristive properties and the brain-like synaptic learning performance of the flexible FTJs are investigated.The results show that multilevel resistance states were maintained well of the flexible artificial synapse,together with their stable synaptic learning properties.Our work indicates the promising opportunity of ferroelectric thin film based flexible synapse used in the future neuromorphic computing system. | Zhen Zhao Amr Abdelsamie Rui Guo Shu Shi Jianhui Zhao Weinan Lin Kaixuan Sun Jingjuan Wang Junling Wang Xiaobing Yan Jingsheng Chen | 2022 | Nano Research2022，15，3： | 2 |
| 18 | Residues of organochlorine pesticides (OCPs) in upper reach of the Huaihe River, East China显示文摘 | Jinglan Feng Mengxiao Zhai Qun Liu Jianhui Sun Jiajia Guo | 2011 | Ecotoxicology and Environmental Safety2011，，8： | 2 |
| 19 | Petroleum Migration Characteristics in the Northeastern Part of the Baiyun Depression,Pearl River Mouth Basin,South China Sea显示文摘This paper investigates the origin and migration characteristics of petroleum in the northeastern part of the Baiyun Depression,Pearl River Mouth Basin(PRMB).The discovered petroleum in the study area is mainly located in the Lower Zhujiang Member(N_(1)z^(2))and mainly originated from the Enping Formation source rocks in the eastern sag.Active faults(vertical migration)and N_(1)z^(2)sandstones(lateral migration)acted as the petroleum migration systems.The fault activities in the Dongsha event controlled the episodic petroleum migration.Fractures in the fault zones provided effective conduits,and overpressure was the driving force.The vertical migration could not cross the fault zones laterally.The petroleum injection areas in the carrier beds were the contact zones of petroleum-migration faults and carrier beds.The lateral migration was steady-state migration,and buoyancy was the driving force.The migration pathways in the carrier beds were controlled by the structural morphology.Secondary petroleum migration in the study area could be divided into two parts:vertical migration along the fractures in the fault zones and lateral migration through preferential petroleum migration pathways(PPMPs)in the carrier beds.The petroleum migration behaviors,including migrating direction,driving force,and migration pattern,in the faults and sandstone carrier beds were quite different.This study provides a typical example for comprehending secondary migration processes and has great importance for determining future exploration targets in the deep-water area of the PRMB. | ZENG Jianhui WANG Chen GUO Shuai YU Yixin ZHANG Zhongtao YANG Haizhang ZHAO Zhao SUN Rui | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 2 |
| 20 | Electrostatic self-assembly of 2D/2D CoWO_(4)/g-C_(3)N_(4)p-n heterojunction for improved photocatalytic hydrogen evolution:Built-in electric field modulated charge separation and mechanism unveiling显示文摘Two-dimensional(2D)semiconductor heterojunctions are considered as an effective strategy to achieve fast separation of photoinduced carriers.Herein,a novel CoWO_(4)/g-C_(3)N_(4)(CWO/CN)p–n junction was synthesized using an electrostatic selfassembly method.The constructed 2D/2D p–n heterostructure had a rich hetero-interface,increased charge density,and fast separation efficiency of photoinduced carriers.The in-situ Kelvin probe force microscopy confirmed that the separation pathway of photoinduced carriers through the interface obeyed an II-scheme charge transfer mechanism.Experimental results and density functional theory calculations indicated the differences of work function between CWO and CN induced the generation of built-in electric field,ensuring an efficient separation and transfer process of photoinduced carriers.Under the optimized conditions,the CWO/CN heterojunction displayed enhanced photocatalytic H_(2)generation activity under full spectrum and visible lights irradiation,respectively.Our study provides a novel approach to design 2D/2D hetero-structured photocatalysts based on p–n type semiconductor for photocatalytic H_(2)generation. | Haiyang Wang Ranran Niu Jianhui Liu Sheng Guo Yongpeng Yang Zhongyi Liu Jun Li | 2022 | Nano Research2022，15，8： | 1 |
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