|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxidative stress modulation in hepatitis C virus infected cells显示文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells. | Sonia A Lozano-Sepulveda Owen L Bryan-Marrugo Carlos Cordova-Fletes Maria C Gutierrez-Ruiz Ana M Rivas-Estilla | 2015 | World Journal of Hepatology2015，7，29： | 6 |
| 2 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 3 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 4 | The role of corticotrophin releasing factor in depress andanxiety disorder显示文摘 | Owens MJ Plotsky PM | 1999 | J Endocrinol1999，160，1： | 1 |
| 5 | Methanesulphonic Anhydride显示文摘 | | 1953 | J Chem Soc1953，3723，： | 1 |
| 6 | Timed ammonia release for steers显示文摘 | Mizwicki K L Owens F N PolingK | 1980 | J Anita Sci1980，51，： | 1 |
| 7 | Inactiva- tion of Cryptosporidium parvum oocysts with ozone显示文摘 | Rennecker J L Marinas B J Owens J H | 1999 | Water Re''search1999，33，11： | 1 |
| 8 | A laboratory evaluationof the wettability of fifty oil-producing reservoirs显示文摘 | TREIBER L E OWENS W W | 1972 | SPE Journal1972，12，6： | 1 |
| 9 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
| 10 | Excitatory GA BA responses in embryonic and neonatal cortical slices demon strated by grarnicidin perforated- patch recordings and calei um imaging显示文摘 | Owens D F Boyce L H Davis M B | 1996 | J Neurosci1996，16，20： | 1 |
| 11 | Military movement training program improves jump-landing mechanics associated with anterior crueiate ligament injury risk 显示文摘 | Owens B D Cameron K L Duffey M L | 2012 | Journal of surgical orthopaedic advances2012，22，1： | 1 |
| 12 | Multiperiodic repetitive control system:A Lyapunov stability analysis for MIMO systems显示文摘 | OWENS D H LI L M BANKS S P | 2004 | International Journal of Control2004，77，5： | 1 |
| 13 | The management of brain metastases in nomsmall cell lung cancer显示文摘 | Owen S Souhami L | 2014 | Front Oncol2014，4，： | 1 |
| 14 | Insulin-like Growth Factor 1 Promotes Growth Selectively in fetal sheep in late gestation 显示文摘 | FONG L JULIE A OWENS L | 1996 | AmJPhysiol1996，270，： | 1 |
| 15 | Sex and Age Differences in Victimi-zation and Conflict Resolution among Adolescents in a SouthAustralian School显示文摘 | Owens L Daly A Slee P | 2005 | Aggressive Behavior2005，31，： | 1 |
| 16 | Storage of sediment-associated nutrients and contaminants in river channel and floodplain systems显示文摘 | Walling D E Owens P N Carter J Leeks G J L Lewis S Meharg A A and Wright J | 2003 | Applied Geochemistry2003，18，： | 1 |
| 17 | Enhancement of Freezing Tolerance of Strawberry by Heterologous Expression of CBFI显示文摘 | OWENS C L LEZZONI A F HANCOCK J F | 2003 | ActaHort2003，，626： | 1 |
| 18 | Distribution of light and heavy fractions of soil organic carbon as related to land use and tillage practice 显示文摘 | TAN Z LAL R OWEN L | 2007 | Soil and Tillage Research2007，92，12： | 1 |
| 19 | Integrating glycaemic vari- ability in the glycaemic disorders of type 2 diabetes: a move to- wards a unified glucose tetrad concept 显示文摘 | Monnier L Colette C Owens DR | 2009 | Diabetes Metab Res Rev2009，25，5： | 1 |
| 20 | Efficacy of anescherichia coli phytase in broilers fed adequate or reducedphosphorus diets and its effect on carcass characteristics显示文摘 | Pillai P B Owens C M Emmert J L | 2006 | Poult Sci2006，85，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员