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| 1 | Hypertrophic cardiomyopathy: Can the noninvasive diagnostic testing identify high risk patients?显示文摘Hypertrophic cardiomyopathy(HCM) is the most common cause of sudden cardiac death(SCD) in the young, particularly among athletes. Identifying high risk individuals is very important for SCD prevention. The purpose of this review is to stress that noninvasive diagnostic testing is important for risk assessment. Extreme left ventricular hypertrophy and documented ventricular tachycardia and fibrillation increase the risk of SCD. Fragmented QRS and T wave inversion in multiple leads are more common in high risk patients. Cardiac magnetic resonance imaging provides complete visualization of the left ventricular chamber, allowing precise localization of the distribution of hypertrophy and measurement of wall thickness and cardiac mass. Moreover, with late gadolinium enhancement, patchy myocardial fibrosis within the area of hypertrophy can be detected, which is also helpful in risk stratification. Genetic testing is encouraged in all cases, especially in those with a family history of HCM and SCD. | Li Zhang Obinna Mmagu Liwen Liu Dayuan Li Yuxin Fan Adrian Baranchuk Peter R Kowey | 2014 | World Journal of Cardiology2014，6，8： | 3 |
| 2 | An evidence-based clinical protocol for diagnosis of acute appendicitis decreased the use of computed tomography in children显示文摘 | Obinna O. Adibe Sejal R. Amin Erik N. Hansen Albert J. Chong Lena Perger Richard Keijzer Oliver J. Muensterer Keith E. Georgeson Carroll M. Harmon | 2011 | Journal of Pediatric Surgery2011，，1： | 1 |
| 3 | Evaluation of quality of TB control services by private health care providers in Plateau state, Nigeria, 2012显示文摘 | LUKA MI OBINNA O PATRICK N | 2014 | Pan Afr Med J2014，，17： | 1 |
| 4 | Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices显示文摘 | Pauline Jolly Yi Jiang William Ellis Richard Awuah Obinna Nnedu Timothy Phillips Jia-Sheng Wang Evans Afriyie-Gyawu Lili Tang Sharina Person Jonathan Williams Curtis Jolly | 2006 | International Journal of Hygiene and Environmental Health2006，，4： | 1 |
| 5 | Evaluation of the microbial community, acidity and proximate composition of akamu , a fermented maize food显示文摘 | Patience C Obinna‐Echem Victor Kuri Jane Beal | 2014 | Food Agric2014，，2： | 1 |
| 6 | Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Perforated Appendicitis: A Prospective Randomized Trial显示文摘 | Shawn D. St Peter Obinna O. Adibe Corey W. Iqbal Frankie B. Fike Susan W. Sharp David Juang David Lanning J. Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder George W. Holcomb Daniel J. Ostlie | 2012 | Annals of Surgery2012，，4： | 1 |
| 7 | Copper tailings as a potential additive in concrete:consistency,strength and toxic metal immobilization properties显示文摘 | Onuaguluchi Obinna Eren Ozgur | 2012 | Indian J Eng Mater Sci2012，，19： | 1 |
| 8 | Cement mixtures containing copper tailings as an additive:durability properties显示文摘 | Onuaguluchi Obinna Eren Ozgur | 2012 | Mater Res2012，，15： | 1 |
| 9 | Appendectomy using single-incision pediatric endosurgery for acute and perforated appendicitis显示文摘 | Oliver J. Muensterer Cecilia Puga Nougues Obinna O. Adibe Sejal R. Amin Keith E. Georgeson Carroll M. Harmon | 2010 | Surgical Endoscopy2010，，12： | 1 |
| 10 | Single incision versus standard 4-port laparoscopic cholecystectomy: A prospective randomized trial显示文摘 | Daniel J. Ostlie Obinna O. Adibe David Juang Corey W. Iqbal Susan W. Sharp Charles L. Snyder Walter S. Andrews Ronald J. Sharp George W. Holcomb Shawn D. St. Peter | 2012 | Journal of Pediatric Surgery2012，，： | 1 |
| 11 | Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain显示文摘 | Obinna I. Ndubuizu Constantinos P. Tsipis Ang Li Joseph C. LaManna | 2010 | Brain Research2010，，： | 1 |
| 12 | Single Incision Versus Standard 3-Port Laparoscopic Appendectomy: A Prospective Randomized Trial显示文摘 | Shawn D. St. Peter Obinna O. Adibe David Juang Susan W. Sharp Carissa L. Garey Carrie A. Laituri J. Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder George W. Holcomb Daniel J. Ostlie | 2011 | Annals of Surgery2011，，4： | 1 |
| 13 | A model for simultaneous matrix depletion into natural and hydraulic fracture network显示文摘 | Obinna E D Hassan D | 2014 | Journal of Natural Gas Science and Engineering2014，16，： | 1 |
| 14 | Rheology, strength and durability properties of mortars containing copper tailings as a cement replacement material显示文摘 | Obinna Onuaguluchi ?zgür Eren | 2013 | European Journal of Environmental and Civil Engineering2013，，1： | 1 |
| 15 | Rapunzel syndrome is not just a mere surgical problem: A case report and review of current management显示文摘Recurrent Rapunzel syndrome(RRS) is a rare clinical presentation with fewer than six cases reported in the Pub Med literature. A report of RRS and literature review is presented. A 25-year-old female was admitted to hospital with a 4-wk history of epigastric pain and swelling. She had a known history of trichophagia with a previous admission for Rapunzel syndrome requiring a laparotomy nine years earlier, aged 16. Psychological treatment had been successfully achieved for nine years with outpatient hypnotherapy sessions only, but she defaulted on her last session due to stressors at home. The abdominal examination demonstrated an epigastric mass. Computer tomography scan revealed a large gastric bezoar and features of aspiration pneumonia. The patient underwent emergency open surgical laparotomy for removal as the bezoar could not be removed endoscopically. The bezoar was cast in a shape that mimicked the contours of the stomach and proximal small bowel, hence the diagnosis of RRS. The patient was seen by a psychiatrist and was commenced on Quetiapine before discharge. She continues to attend follow-up. | Obinna Obinwa David Cooper Faraz Khan James M O'Riordan | 2017 | World Journal of Clinical Cases2017，5，2： | 1 |
| 16 | 用磷酸二酯酶抑制剂对供体移植的脉管系统定向保护增加自体脂肪移植的成活量和可预测性显示文摘背景移植脂肪长期成活量的不可预测性,使脂肪移植的应用受到限制。作者认为,主要是在提取的过程中,供体微脉管系统受到损伤,然后引起缺血,所以导致其结果不稳定。有学者研究发现,美国食品药品管理局批准使用的磷酸二酯酶-5抑制剂枸橼酸西地那非(sildenafil)片能保护移植的微脉管系统,维持其在血管再生和存活中的作用。方法取Tie21LacZ大鼠的腹股沟脂肪,用西地那非或盐水浸润,提取,并移植到FVB大鼠的背部。其他的供体大鼠在提取和移植前,灌注胰蛋白酶,使脂肪移植的微脉管系统失活。对移植的血管再生、灌注、脂肪成活量和生物变化进行测定。结果存活脂肪移植物的脉管系统能与受体周围融合一起。供者的微脉管系统失活降低了早期脂肪移植的灌注,移植8周时,几乎失去全部脂肪。西地那非能减弱血管缺血的损伤,48h时,VCAM-1和SDFlα的表达减少;2周时,与对照组相比,微脉管系统的成活量增加4倍。定向西地那非治疗能改善早期的脂肪灌注;12周时,移植脂肪的保留量增加1倍(85%:59%,P〈0.05);24周时,组织学特征表明仍保留原始脂肪的64%。结论脂肪移植脉管系统主要依赖于供体微脉管系统的维护情况。西地那非在移植和血管再生中能保护供体微脉管系统,增加移植脂肪的长期成活量。本研究介绍了一种在临床实践中增加脂肪移植的可预测性和耐久性的方法。 | Marc A. Soares Obinna C. Ezeamuzie I Maria J. Ham April M. Duckworth Piul S. Rabbani Pierre B. Saadeh Daniel J. Ceradini 叶美辰 高景恒 张晨 袁继龙 | 2015 | 中国美容整形外科杂志2015，26，10： | 0 |
| 17 | CRISPR-Cas9 System:a Revolutionary Tool in the Fight Against Antimicrobial Resistance:Retracted显示文摘The rapidly evolving world of antimicrobial resistance has not only made it difficult to combat infectious diseases,but during the last decades also brought the discovery of novel antimicrobials to a standstill.In recent years,researchers discovered the potential of the clustered regularly interspaced short palindromic repeats(CRISPR)-associated(CRISPR-Cas)system as an alternative therapeutic.Since the unearthing of CRISPR-Cas9 as an“adaptive immune system”of bacteria,the CRISPR-Cas9 system has been improved into a state-of-the-art genetic engineering tool,with an impressive ability to cause specific gene insertions and/or gene deletions,in almost all microorganisms.The emerging picture suggests that the CRISPR-Cas9 system can be exploited in a sequence-specific manner to selectively eliminate individual bacterial strains in a mixed microbial population,and/or re-sensitize bacteria to antibiotics.These findings have not only revolutionized biomedical research,but might also prove to be pivotal in creating novel alternative treatments for multidrug-resistant infections.Here,we discussed the up-to-date findings reported in this area,as well as the approaches involved in the utilization of CRISPR-Cas9 as a novel technology in the fight against antimicrobial resistance.We also highlighted recent studies that have exploited the CRISPR-Cas9 system in the context of targeting pathogenic and drug-resistant bacteria. | Osmond C.Ekwebelem Job Aleke Ekenedirichukwu Ofielu Obinna Nnorom-Dike | 2021 | Infectious Microbes & Diseases2021，3，2： | 0 |
| 18 | Active tracking of rejected dried blood samples in a large program in Nigeria显示文摘AIM: To study the impact of rejection at different levels of health care by retrospectively reviewing records of dried blood spot samples received at the molecular laboratory for human immunodeficiency virus(HIV) early infant diagnosis(EID) between January 2008 and December 2012.METHODS: The specimen rejection rate, reasons for rejection and the impact of rejection at different levels of health care was examined. The extracted data were cleaned and checked for consistency and then deduplicated using the unique patient and clinic identifiers. The cleaned data were ciphered and exported to SPSS version 19(SPSS 2010 IBM Corp, New York, United States) for statistical analyses.RESULTS: Sample rejection rate of 2.4%(n = 786/32552) and repeat rate of 8.8%(n = 69/786) were established. The mean age of infants presenting for first HIV molecular test among accepted valid samples was 17.83 wk(95%CI: 17.65-18.01) vs 20.30 wk(95%CI: 16.53-24.06) for repeated samples. HIV infection rate was 9.8% vs 15.9% for accepted and repeated samples. Compared to tertiary healthcare clinics, secondary and primary clinics had twofold and three-fold higher likelihood of sample rejection, respectively(P < 0.05). We observed a significant increase in sample rejection rate with increasing number of EID clinics(r = 0.893, P = 0.041). The major reasons for rejection were improper sample collection(26.3%), improper labeling(16.4%) and insufficient blood(14.8%). CONCLUSION: Programs should monitor pre-analytical variables and incorporate continuous quality improvement interventions to reduce errors associated with sample rejection and improve patient retention. | Auchi Inalegwu Sunny Phillips Rawlings Datir Christopher Chime Petronilla Ozumba Samuel Peters Obinna Ogbanufe Charles Mensah Alash'Le Abimiku Patrick Dakum Nicaise Ndembi | 2016 | World Journal of Virology2016，5，2： | 0 |
| 19 | Antimalarial activity of Ageratum conyzoides in combination with chloroquine and artesunate显示文摘Objective:To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides(A.conyzoides) in combination with chloroquine and artesunate, respectively against Plasmodium berghei infection in mice.Methods:Using malaria(Plasmodium berghei) infected albino mice of both sexes,aqueous extracts of A.conyzoides in combination with chloroquine and artesunate were tested for antimalarial activity,respectively.Four-day suppressive test and Rane’s curative test were carried out.Results:Suppressive tests showed significant dose dependent reduction in parasitemia level produced by the extract-chloroquine and extract-artesunate combinations.Suppressive activities of both extract-drug combinations were greater than the individual drugs alone.Extract-chloroquine(100:5) produced the highest suppressive effect(98%suppression).Curative tests showed absolute survival in two extract-drug combinations.Two extract-drug combinations produced higher curative effects than the individual drugs alone.The highest dose combinations of extract-chloroquine(100:5) and extract-artesunate(100:5) produced absolute parasitemia clearance(cure) in the infected mice. Conclusions:The study indicated that aqueous extract of A.conyzoides had the ability to potentiate the antimalarial activity of chloroquine and artesunate against induced plasmodiasis in mice.It contributes a lot in the malaria endemic and poverty stricken tropics. | Ukwe Chinwe V Ekwunife Obinna I Epueke Ebele A Ubaka Chukwuemeka M | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 0 |
| 20 | Sedimentary facies and textural characteristics of Cretaceous sandstones in the southern Bida Basin,Nigeria:Implication for reservoir potential and depositional environment显示文摘A study of sedimentary facies,mineral and textural characteristics of sections of conglomerates/pebbles and sandstone facies found within the Lokoja and Patti Formations in southern Bida Basin,Nigeria,is carried out to evaluate the paleo-environment and reservoir quality of the sandstones of the formations through field observations and textural and mineralogical(using X-Ray Diffractogram)analyses.Nine lithofacies are identified and grouped into three main facies associations.These sedimentary facies suggest deposition in both foreshore and estuaries.The mineral analysis(XRD)shows that the quartz content in sandstone facies of the Lokoja Formation ranges between 49%and 67%,and that of the Patti Sandstone between 43%and 56%,indicating a quartz dominance.The granulometric studies reveal that the Lokoja Formation comprises coarse-to medium-grained(-0.63 to 1.30φ)sandstone with moderatepoor sorting of 0.72e1.824.On the other hand,medium to fine-grained sandstones dominate the Patti Formation,which is averagely poorly sorted(1.29-1.54φ).The sandstones are coarsely skewed to finely skewed,with the kurtosis ranging from very platykurtic to leptokurtic.Morphological results of the pebbles from both Lokoja and Patti Formations indicate that the study areas are mainly characterized by the interplay of both wave and fluvial processes,which suggests that the environment of deposition of sandstone facies is predominantly of the fluvial to the shallow marine environment with the indication of tidal influence.Integrating sedimentary facies and textural results suggests subtidal sand ridge/foreshore,estuarine mudflat,and estuarine delta environments with fluvial influences.Evidence from the textural and mineral characteristics indicate that the sandstone facies of the Lokoja and Patti Formations are fairly matured and can act as potential hydrocarbon reservoirs in the formations.The facies,XRD mineral,and textural results have revealed potential hydrocarbon reservoir areas and paleo-depositional features of the Lokoja and Patti Formations. | Godwin Okumagbe Aigbadon Simon Dalom Christopher Ernest Orji Akudo Obinna Chigoziem Akakuru | 2022 | Energy Geoscience2022，3，3： | 0 |
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