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| 1 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 3 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 4 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 5 | Early-onset gastric cancer:Learning lessons from the young显示文摘There is by no means a clear-cut pattern of mutations contributing to gastric cancers,and gastric cancer research can be hampered by the diversity of factors that can induce gastric cancer,such as Helicobacter pylori infection,diet,ageing and other environmental factors.Tumours are unquestionably riddled with genetic changes yet we are faced with an unsolvable puzzle with respect to a temporal relationship.It is postulated that inherited genetic factors may be more important in early-onset gastric cancer (EOGC) than in gastric cancers found in older patients as they have less exposure to environmental carcinogens.EOGC,therefore,could provide a key to unravelling the genetic changes in gastric carcinogenesis.Gastric cancers occurring in young patients provide an ideal background on which to try and uncover the initiating stages of gastric carcinogenesis.This review summarizes the literature regarding EOGC and also presents evidence that these cancers have a unique molecular-genetic phenotype,distinct from conventional gastric cancer. | Anya N Milne G Johan A Offerhaus | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 6 | Targets for molecular therapy in esophageal cell carcinoma:an immunohistochemical analysis显示文摘 | Boone J van Hillegersberg R Offerhaus G J | | 0，，06： | 1 |
| 7 | Experssion of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 | Wielenga V J Heider KH Offerhaus G J | 1993 | Caner Res1993，53，20： | 1 |
| 8 | Leptin is a growth factor for colonic epithelial cells显示文摘 | Hardwick J C Van Den Brink G R Offerhaus G J | 2001 | Gastroenterology2001，121，1： | 1 |
| 9 | Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 | WIELENGA V J HEIDER K H OFFERHAUS G J | 1993 | Cancer Res1993，53，20： | 1 |
| 10 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 11 | I- dentification of molecular aherations in gas- trointestinal carcinomas and dyplastic hamartomas in Peutz-Jeghers syndrome显示文摘 | Korsses E Biermann K Offerhaus G et ai | 2013 | Carcinogenesis2013，34，： | 1 |
| 12 | Role of Cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma显示文摘 | BUSKENS C J RISTIMAKI A OFFERHAUS G J | 2003 | Scand J Gastronenterol Suppl2003，239，： | 1 |
| 13 | Large mode area fibers for high power applications 显示文摘 | BRODERICK N G R OFFERHAUS H L RICHARDSON D J | 1999 | Optical Fiber Technology1999，，5： | 1 |
| 14 | Pancreaticcarcinogenesis显示文摘 | Koorstra J B M Hustinx S R Offerhaus G J A Maitra A | 2008 | Pancreatology2008，8，： | 1 |
| 15 | Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 | Wielenga V J Heider K H Offerhaus G JA | 1993 | Cancer Res1993，53，20： | 1 |
| 16 | Prognostic value of Lauren classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction 显示文摘 | POLKOWSKI W VAN SANDICK J W OFFERHAUS G J | 1999 | Ann Surg Oncol1999，6，3： | 1 |
| 17 | Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 | Heider K H Offerhaus G J A | 1993 | Cancer Res1993，53，20： | 1 |
| 18 | Survival af- ter pancreatieoduodenectomy for periampullary adenocarcinoma: an update 显示文摘 | van Geenen RC van Gulik TM Offerhaus G] | 2001 | Eur J Surg Oncol2001，27，6： | 1 |
| 19 | Hexagonally Poled Lithium Niobate: A Two-Dimensional Nonlinear Photonic Crystal显示文摘 | Broderick N G R Ross G W Offerhaus H L | 2000 | Physical Review Letters2000，84，： | 1 |
| 20 | Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression显示文摘 | Wielenga V J M Heider K H Offerhaus G j A | 1993 | Cancer Res1993，53，20： | 1 |
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