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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage Ⅰ chronic obstructive pulmonary disease显示文摘 | Ofir D Laveneziana P Webb KA | | 0，，6： | 1 |
| 3 | Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease显示文摘 | Ofir D Laveneziana P Webb K A | 2008 | Am J Respir Crit Care Med2008，177，6： | 1 |
| 4 | A methodology and model for the pun-ln parameters of eleetrostatle aetuator 显示文摘 | NEMIROVSKY Y OFIR B D | 2001 | Journal of Microelectromechanical Systems2001，10，4： | 1 |
| 5 | MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E显示文摘 | Ofir M Hacohen D Ginsberg D | | 0，，04： | 1 |
| 6 | Measuring Images of Foreign Products显示文摘 | OFIR C LEHMANN D R | | 0，，02： | 1 |
| 7 | Intraneuronal amyloid-β plays a role in mediating the synergistic pathological effects of apoE-4 and environmental stimulation显示文摘 | OFIR L IFTACH D HAIM B | 2007 | Journal of Neurochemistry2007，103，： | 1 |
| 8 | Audio packet loss concealment in a combined MDCT-MDST domain显示文摘 | Ofir H Malah D Cohen I | 2007 | IEEE Signal Processing Letters2007，14，10： | 1 |
| 9 | Comparison of oral mucosal pH values in bulimia nervosa,GERD,BMS patients and healthy population显示文摘 | Aframian D J Ofir M Benoliel R | 2010 | Oral Dis2010，16，： | 1 |
| 10 | A methodology and model for the pull-in parameters of electrostatic actuators 显示文摘 | OFIR B D | 2001 | Journal of MEMS2001，10，4： | 1 |
| 11 | miR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-in- duced proliferation by targeting Cyclin E显示文摘 | OFIR M HACOHEN D GINSBERG D | 2011 | Molecular Cancer Research2011，9，4： | 1 |
| 12 | Pull-in study of an electrostatic torsion microactuator 显示文摘 | Ofir D Eran S Ariel L | 1998 | J of Microelectromechanical Systems1998，7，4： | 1 |
| 13 | Ventilatory and perceptual responses to cycle exercise in obese women 显示文摘 | Ofir D Laveneziana P Webb KA | 2007 | J Appl Physiol2007，102，6： | 1 |
| 14 | 信息技术“阴暗面”显示文摘法国最新劳动法规定,法国科技企业在晚上6点后到早上9点之前的非正常工作时间,向员工发送邮件或打电话属于违法行为。德国似乎也在做这方面的努力。虽然这一趋势不太可能在所有国家和企业延展,但至少应当引发更多企业管理者与政策制定者的思考:过度使用信息技术是否会对员工的健康造成损害? | Monideepa Tarafdar John D’Arcy Ofir Turel Ashish Gupta | 2015 | 董事会2015，0，4： | 0 |
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