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3446篇 您的检索式:作者名="Oh K"
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14-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon 2017Cellular & Molecular Immunology2017,14,9:6
2Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species显示文摘This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic range.The new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique morphology.The family is sister to Biatriosporaceae and Roussoellaceae.The new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,A.muriformia,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,C.aureum,C.frutexensis,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,C.sibiraeae,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,D.meiosporum,D.thailandicum,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,K.spartii,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,L.ravennicum,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,N.italica,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,P.thysanolaenae,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,P.dracontomelon,P.italiana,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tamarindi,Pseudotrichia rubriostiolata,P.thailandica,Psiloglonium multiseptatum,Saagaromyces mangrovei,Sarimanas pseudofluviatile,S.shirakamiense,Tothia spartii,Trichomerium siamensis,Wojnowicia dactylidicola,W.dactylidis and W.lonicerae.The Basidiomycota Agaricus flavicentrus,A.hanthanaensis,A.parvibicolor,A.sodalis,Cantharellus luteostipitatus,Lactarius atrobrunneus,L.politus,Phylloporia dependens and Russula cortinarioides are also introduced.Epitypifications or reference specimens are designated for Hapalocystis berkeleyi,Meliola tamarindi,Pallidocercospora acaciigena,Phaeosphaeria musae,Plenodomus agnitus,Psiloglonium colihuae,P.sasicola and Zasmidium musae while notes and/or new sequence data are provided for Annulohypoxylon leptascum,A.nitens,A.stygium,Biscogniauxia marginata,Fasciatispora nypae,Hypoxylon fendleri,H.monticulosum,Leptosphaeria doliolum,Microsphaeropsis olivacea,Neomicrothyrium,Paraleptosphaeria nitschkei,Phoma medicaginis and Saccotheciaceae.A full description of each species is provided with light micrographs(or drawings).Molecular data is provided for 90 taxa and used to generate phylogenetic trees to establish a natural classification for species.Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin Zhao Erio Camporesi 2015Fungal Diversity2015,,3:3
3血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。Lee K W Kim J S Oh S T Kang C W An B K 2015饲料博览2015,0,3:2
4Network - based approach to on -line cursive script recognition 显示文摘SIN B K HA J Y OH S C 1999IEEE Transaction on System Man and Cybernetics-Part B:Cybernetics1999,29,2:2
5Estimating Directions - of - arrival of Coherent Signals in Unknown Correlated Noise Via Spatial Smoothing 显示文摘Tan K C Oh G L 1997IEEE Trans Signal Processing1997,45,4:1
6Effect of continuous lumbar traction on the size of herniated disc material in lumbar disc herniation 显示文摘Ozturk B Gunduz OH Ozoran K 2006Rheumatol Int2006,26,7:1
7Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana显示文摘OH S A PARK J H LEE G I PACK K H PARK S K NAM H G 1997Plant Journal1997,12,3:1
8Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘Seol D J Won Y M Oh K H 2000ISIJ International2000,40,4:1
9Microstruetural characterization of Al2O3-Ni composites prepared by electroless deposition 显示文摘OH I H LEE J Y HAN J K 2005Surf Coat Technol2005,192,:1
10Antiherpetic activities of acidic protein bound polysaccharide isolated from Ganoderma lucidumalone and in combinations with mterferons 显示文摘Kim Y S Eo S K Oh K W etal 2000J Ethnopharmacol2000,72,3:1
11Si-carbon core-shell composite anode in lithium secondary batteries 显示文摘JUNG Y S LEE K T OH SEUN M 2007Electrochimica Acta2007,52,:1
12A cytochrome P450 gene is differentially expressed in compa-ible and incompatible interactions between pepper(Capsicum annuum)and the anthracnose fungus,Colletotrichum gloeosp-orioides显示文摘 Ko M K Kim Y S 1999Mol Plant-microbe Interaction1999,12,:1
13Synaptopodin regulates the actinbundling activity of alpha-acrinin in an isoform-specific manner显示文摘Asanuma K Kim K Oh J 2005J Clin Invest2005,115,5:1
14Simulation of target detection in ultraviolet and infrared bands显示文摘DOO K S OH JS JAHNG S G 2001Opt Eng2001,40,11:1
15Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease显示文摘Okuda S Oh Y Tsuruda H Onoyama K Fujimi S Fujishima M 1986Kidney Int1986,29,2:1
16Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid显示文摘KIM J H YOO S J OH D K 1996Enzyme Microb Tech1996,19,6:1
17Surface plasmon resonance immunosensor for the detection of Salmonella typhimurium 显示文摘OH B K KIM Y K PARK K W 2004Biosens Bioelectron2004,19,11:1
18Axiomatic design of machine control System显示文摘LEE K D SUH N P OH J H 2001Annals of the CIRP2001,50,1:1
19Combination of in vitro bioassays encompassing different mechanisms to determine the endocrinedisrupting effects of river water显示文摘Oh SM Park K Chung KH 2006Sci Total environ2006,354,23:1
20Some volatile compounds formed from thermal interaction of glucose with glycine,diglycine,triglycine,and tetraglycine显示文摘Oh Y C Shu C K Ho C T 1991J Agric Food Chem1991,39,:1
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