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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1显示文摘 | Ohara J P W | 1985 | Nature1985，315，6017： | 1 |
| 3 | A common oocyst surface antigen of Crytosporidium recognized by monoclonal antibodies显示文摘 | YU J R OHARA S P LIN J L | 2002 | Parasitol Res2002，88，5： | 1 |
| 4 | Gliopathic pain:when satellite glial cells go bad显示文摘 | Ohara P T Vit J P Bhargava A | 2009 | The Neuroscientist2009，15，5： | 1 |
| 5 | Acute and sublethal toxicity of naphthalene and three methylated derivatives to the estuarine copepod, Eurytemoraaffinis显示文摘 | OTT F S HARRIS P OHARA S C M | 1978 | Marine Environ Res1978，，1： | 1 |
| 6 | Size-controlled synthesis of Au nanoparticles显示文摘 | Leff D Ohara P Heath J | 1995 | J Phys Chem1995，99，： | 1 |
| 7 | Interplay between hole instability and nanoparticle array formation in ultrathin liquid films显示文摘 | Gelbart W M Ohara P C | 1998 | Langmuir1998，14，： | 1 |
| 8 | Thermodynamic control of gold nanocrystal size: Experiment and theory 显示文摘 | Leff D V Ohara P C Heath J R | 1995 | J Phys Chem1995，99，18： | 1 |
| 9 | Self-assembly of submicrome- ter rings of particles from solutions of nanopartieles显示文摘 | Ohara P C Heath J R Gelbart W M | 1997 | Angew Chem Int Ed1997，36，10： | 1 |
| 10 | Cortical modulation of pain显示文摘 | Ohara P T Vit J P Jasmin L | 2005 | Cell Mol Life Sci2005，62，1： | 1 |
| 11 | Extended -release divalprcex in child and adolescent out-patients with epilepsy显示文摘 | OHara KA Jiang P | 2005 | Epilepsia2005，46，3： | 1 |
| 12 | Infectious cDNA clones of the DA strain of Thciler' s murine encephalomyelitis virus 显示文摘 | Stein S Ohara Y | 1989 | J Virol1989，63，： | 1 |
| 13 | Upregulation of aquaporin-2 water channel expression in chronic heart failure rat 显示文摘 | Xu D Martin P Ohara M | 1997 | J Clin Invest1997，99，： | 1 |
| 14 | Quantitative analyses of intraeellularly characterized and labeled thalamocortical projection neurons in the ventrobasal complex of primates 显示文摘 | HAVTON L A OHARA P T | 1993 | J CompNeurol1993，336，1： | 1 |
| 15 | Quantitative analyses of intracellularly characterized and labeled thalamocortical projection neurons in the ventrobasal complex of primates 显示文摘 | HAVTON L A OHARA P T | 1993 | J Comp Neurol1993，336，1： | 1 |
| 16 | Self-Assembly of Submicrometer Rings of Particles from Solutions of Nanoparticles 显示文摘 | Ohara P C Heath J R Gelbart W M | 1997 | Angew Chem Int Ed Engl1997，36，10： | 1 |
| 17 | Nitric oxide synthase(NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites显示文摘 | MARTIN PY OHARA M GINES P | 1998 | J Clin Invest1998，101，： | 1 |
| 18 | Crystallization of opals from polydisperse nanoparti-cles 显示文摘 | LEFF D V HEALTH J R | 1995 | Phys Rev Lett1995，75，： | 1 |
| 19 | Evidence for a role of eonnexin 43 in trigeminal pain using RNA interference in vivo显示文摘 | OHARA P T VIT J P BHARGAVA A | 2008 | Journal of Neurophysiology2008，100，6： | 1 |
| 20 | Upregulation of aquaporin-2water channel expression in pregnant rats显示文摘 | OHARA M MARTIN P Y XU D L | 1998 | Journal of ClinicalInvestigation1998，101，5： | 1 |
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