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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging显示文摘Pulmonary contrast enhanced magnetic resonance angiography(CE-MRA) is useful for the primary diagnosis of pulmonary embolism(PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography(CTA). In this review, we discuss the strengths and weaknesses of CEMRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multiinstitutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women(< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness(patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE. | Nanae Tsuchiya Edwin JR van Beek Yoshiharu Ohno Hiroto Hatabu Hans-Ulrich Kauczor Andrew Swift Jens Vogel-Claussen Jürgen Biederer James Wild Mark O Wielpütz Mark L Schiebler | 2018 | World Journal of Radiology2018，10，6： | 4 |
| 3 | Effect of sulphur addition on the properties of Fe- Ti alloy for hydrogen storage显示文摘 | Suzuki R Ohno J Gondoh H | 1984 | J Less Common Met1984，104，1： | 1 |
| 4 | Thymoma:results with complete resection and adjuvant postoperative irradiation in 141 consecutive patients显示文摘 | Nakahara K Ohno K Hashimoto J | 1988 | J Thorac Cardiovasc surg1988，95，： | 1 |
| 5 | Atypical Antipsychotic Properties o Blonanserin,A Novel Dopamine D2 And 5-Ht2a Antagonist显示文摘 | Ohno Y Okano M Imaki J | 2010 | Pharmacology Biochemistry&Behavior2010，96，2： | 1 |
| 6 | Pretreatment neutrophil -to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma 显示文摘 | Ohno Y Nakashima J Ohori M Hatano T Tachibana M | 2010 | J Urol2010，184，3： | 1 |
| 7 | Immunopharmaeological character-ization of a highly branched fungal (1→3)- beta-D-glucan, OL-2, isolatedfrom Omphalia lapidescens 显示文摘 | Ohno N Saito K Nemoto J | 1993 | Biological & Pharmaceutical Bulletin1993，16，4： | 1 |
| 8 | Zonisamide treatment of early infantile epileptic encephalopathy显示文摘 | Ohno M Shimotsuji Y Abe J | 2000 | Pediatr Neurol2000，23，4： | 1 |
| 9 | High-dose-rate interstitial brachytherapy wit computed tomography-based treatment planning for patients with locall advanced uterine cervical carcinoma显示文摘 | Saitoh J Ohno T Sakurai H | 2011 | J Radial Res(Tokyo)2011，52，4： | 1 |
| 10 | Immuno- pharmacological characterization of a highly branched fungal(1→3)-beta-D-glucan, OL-2, isolated from Omphalia lapidescens 显示文摘 | Ohno N Saito K Nemoto J | 1993 | Bio Pharm Bull1993，16，4： | 1 |
| 11 | TOPLESS regulates apical embryonic fate in Arabidopsis显示文摘 | LONG J A OHNO C SMITH Z R | 2006 | Science2006，312，： | 1 |
| 12 | Size effect in high-strength concrete cylinders subjected to axial impact 显示文摘 | Krauthammer T Elfahal M M Lim J H Ohno T Beppu M Markeset G | 2003 | International Journal of Impact Engineering2003，28，： | 1 |
| 13 | Expression of bcl-2 protein,an inhibitor of apoptosis,and Bax,an accelerator of apoptosis,in ventrieular myocytes of human hearts with myocardial infarction显示文摘 | Misao J Hayakawa Y Ohno M | 1996 | Circulation1996，94，7： | 1 |
| 14 | Simulation model of an eyeball based on finite element analysis on a supercomputer显示文摘 | Uchio E Ohno S Kudoh J | 1999 | Br J Ophthalmol1999，83，10： | 1 |
| 15 | Zener model description of ferromagnetism in zine-blende magnetic semiconductors 显示文摘 | Died T Ohno H Matsukura F Cibert J Ferrand D | 2000 | Science2000，278，： | 1 |
| 16 | Pentavalcnt vanadium at concentration of the underground water level enhances the sweet taste sense to glucose in college students 显示文摘 | NAGAI M SAITON J OHNO H | 2006 | Biometals2006，19，1： | 1 |
| 17 | hnmunopharmacological character-ization of a highly branched fungal(1→3)beta-D- glucan,OL-2, isolatedfrom Omphalia lapidescens显示文摘 | Ohno N Saito K Nemoto J | 1993 | Biological & PharmaceuticalBulletin1993，16，4： | 1 |
| 18 | High Twist expression is involved in infiltrative endometrial cancer and affects patient survival显示文摘 | Kyo S Sakaguchi J Ohno S | 2006 | Hum Pathol2006，37，4： | 1 |
| 19 | Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction 显示文摘 | Misao J Hayakawa Y Ohno M Kato S Fujiwara T Fujiwara H | 1996 | Circulation1996，94，7： | 1 |
| 20 | High twist expression is involved in infiltrative endometrial cancer and affects patient survival显示文摘 | Kyo S Sakaguchi J Ohno S | 2006 | Human Pathology2006，37，4： | 1 |
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