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| 1 | A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis显示文摘A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography (CT) or nuclear magnetic resonance imaging (MRI). However, endoscopic retrograde cholangiopancreatography (ERCP) demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment (B5) and narrowness of the intrahepatic bile duct in the anterior superior segment (B8), so that we strongly suspected intrahepatic cholangiocarcinoma (ICC). Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor (MUC5AC+/CK7+) was compatible with an intraductal papillary neoplasm of the bile duct (IPN-B). Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ(pT1, pN0, P0, H1, M0). We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells. | Junpei Hayashi Shyun-ichi Matsuoka Makiko Inami Shu Ohshiro Akiyasu Ishigami Hirotoshi Fujikawa Masahide Miyagawa Kenji Mimatsu Youichi Kuboi Hisao Kanou Takatsugu Oida Makiko Inami Shu Ohshiro Mitsuhiko Moriyama | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 2 | Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice显示文摘 | Fumitake Usui Hiroaki Kimura Taichi Ohshiro Kazuki Tatsumi Akira Kawashima Akiyo Nishiyama Yo-ichiro Iwakura Shun Ishibashi Masafumi Takahashi | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 2 |
| 3 | Branches of the persistent primitive trigeminal artery: an autopsy case显示文摘 | Ohshiro S Inoue T Hamada Y | 1993 | Neurosurgery1993，32，1： | 1 |
| 4 | Molecular mechanism of diabetic nephropathy 显示文摘 | Ohshiro Y Takasu N | 2006 | Nippon Rinsho2006，64，5： | 1 |
| 5 | Alternate estrogen re- ceptors promote invasion of inflammatory breast cancer cells via non- genomic signaling显示文摘 | Ohshiro K Schwartz A M Levine P H | 2012 | PLoS One2012，7，30： | 1 |
| 6 | Beneficial effect of switching from a combination of angiotensin ii receptor blockers other than losartan and thiazides to a fixed dose oflosartan/hydroch显示文摘 | Ohshiro K Sakima A Nakada S | 2011 | Clin Exp Hypertens2011，33，8： | 1 |
| 7 | Identification of a novel estro- gen reeeptor-alpha variant and its upstream splicing regulator显示文摘 | Ohshiro K Mudvari P Meng QC | 2010 | Mol Endocrino12010，24，5： | 1 |
| 8 | Dibenzothiophene(DBT) degrading enzyme responsible for the first step of DBT desulfurization by rhodococcus erythropolis D-1:purification and characterization显示文摘 | Ohshiro T Suzuki K Izumi Y | 1997 | Journal of Fermentation and Bioengineering1997，83，3： | 1 |
| 9 | Purification, characterization and overexpression of flavin reductase in- volved in dibenzothiophene desulfurization by Rhodo- coccus erythropolis D - 1 显示文摘 | MATSUBARA T OHSHIRO T | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 10 | Appraisal of myocutaneous flapping for treatment of postmastectomy lymphedema 显示文摘 | Kambayashi J Ohshiro T Mori T | 1990 | Ac- ta Chir Scand1990，156，2： | 1 |
| 11 | Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma , not otherwise specified , by immunohistochemical analysis显示文摘 | Matsumoto Y Horiike S Ohshiro M | 2010 | Am J Clin Pathol2010，133，2： | 1 |
| 12 | Appraisal of myocutaneous flapping for treatment of postmastectomy lymphedema显示文摘 | Ohshiro T Mori T | 1990 | Acta Chir Scand1990，156，2： | 1 |
| 13 | Atomic force mi- croscopy to study direct neurite-mast cell (RBL) commu- nication in vitro 显示文摘 | Ohshiro H Suzuki R Furuno T | 2001 | Immunol Lett2001，74，3： | 1 |
| 14 | Glomerular-specific protein kinase C-betainduced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity显示文摘 | Mima A Ohshiro Y Kitada M | 2011 | Kidney Int2011，79，： | 1 |
| 15 | Inhibitory effects of nitric oxide on oxidative phosphorylation in plant mitochondria显示文摘 | YAMASAKI H SHIMOJI H OHSHIRO Y SAKIHAMA Y | 2001 | Nitric Oxide2001，5，： | 1 |
| 16 | Desulfurization of dibenzothiophene to 2-hydroxybiphenyl by Some Newly Isolated Bacteria Strains显示文摘 | Izumi Y Ohshiro T | 1994 | Appl Environ Microbiol1994，60，： | 1 |
| 17 | Inhibitory effects of nitric oxide on oxidative phosphorylation in plant mitoehondria 显示文摘 | Yamasaki H Shimoji H Ohshiro Y Sakihama Y | 2001 | Nitric Oxide2001，5，3： | 1 |
| 18 | MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response显示文摘 | Da-Qiang Li Sujit S. Nair Kazufumi Ohshiro Anupam Kumar Vasudha S. Nair Suresh B. Pakala Sirigiri Divijendra Natha Reddy Rajendra P. Gajula Jeyanthy Eswaran L. Aravind Rakesh Kumar | 2012 | Cell Reports2012，，6： | 1 |
| 19 | Selective desulfurization of dibenzothiophene by Rhodococcus erythropolis D-1显示文摘 | IZUMI Y OHSHIRO T OGINO H | 1994 | Appl Environ Microbiol1994，60，1： | 1 |
| 20 | Pak protein kinases and their role in cancer显示文摘 | Dummler B Ohshiro K Kumar R | | 0，，1： | 1 |
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