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| 1 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 2 | Teachers’Stressors and Strains:a Longitudinal Study of Their Relationships显示文摘 | Shirom A Oliver A Stein E | 2009 | International Journal of Stress Management2009，16，4： | 1 |
| 3 | Increased expression of ADAM33 and ADAM88 with disease progession in asthma 显示文摘 | Foley SG Mogas AK Olive stein R | 2007 | J A1-lergy Clin Immunol2007，119，4： | 1 |
| 4 | Multigene Analysis Can Discriminate Between Ulcerative Colitis, Crohn’s Disease, and Irritable Bowel Syndrome显示文摘 | Petra von Stein Robert Lofberg Nikolai V. Kuznetsov Alexander W. Gielen Jan–Olov Persson Rolf Sundberg Karin Hellstrom Anders Eriksson Ragnar Befrits Ake Ost Oliver D. von Stein | 2008 | Gastroenterology2008，，： | 1 |
| 5 | 铝颗粒粉尘对冲火焰数值模拟研究显示文摘铝颗粒由于具有能量密度高、易储存、燃烧过程不产生温室气体等优势,有望成为未来化石燃料替代的解决方案.本文建立了铝颗粒粉尘火焰的燃烧模型,其中考虑了相间传热、相变、表面化学反应、气相详细化学反应及辐射传热等过程,并针对铝颗粒粉尘对冲火焰开展了数值模拟研究.首先,通过仿真McGill大学的铝颗粒粉尘对冲火焰实验进行模型验证,并分析了实验中使用铝颗粒本身作为示踪粒子引起的气相速度测量误差,结果表明,数值模拟得到的离散相速度分布与实验结果基本一致,火焰传播速度的预测值也同实验数据吻合较好.当颗粒粒径小于10μm时,连续介质假设不再成立,相间传热模型必须考虑过度区机制,随着颗粒粒径的增加,火焰传播速度不断降低.随着对冲火焰拉伸率的增加,颗粒在火焰区的停留时间减少,并出现燃烧不完全的现象,粉尘火焰由双峰变为单峰结构.火焰传播速度随着拉伸率的增加而增大,通过线性外推可得到未拉伸的火焰传播速率约为29 cm/s.辐射引起的热损失会导致气相温度大幅降低,但辐射传热对颗粒的加热作用相对较小. | 张家瑞 夏智勋 方传波 马立坤 冯运超 Oliver Stein Andreas Kronenburg | 2022 | 物理学报2022，71，7： | 1 |
| 6 | Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis显示文摘 | Liu Y Stein E Oliver T | 2004 | Curr Biol2004，14，10： | 1 |
| 7 | Novel role for netrins in regulating epithelial behaviour during lung hranehing morphogenesis显示文摘 | Liu Y Stein E Oliver T Li Y Brunken W J Koch M | 2004 | Curr Biol2004，14，： | 1 |
| 8 | Novel role for netrins in regulating epithelial beha'viour during lung branching morphogenesis 显示文摘 | Liu Y Stein E Oliver T | 2004 | Curr Biol2004，14，10： | 1 |
| 9 | LES of the Sydney Swirl Flame Series: a Study of Vortex Breakdown in Isothermal and Reacting Flows 显示文摘 | Oliver Stein Andreas Kempf | 2007 | Proceedings of the Combustion Institute2007，31，： | 1 |
| 10 | New introducer PEG gastropexy does not require prophylactic antibiotics: multicenter prospective randomized double-blind placebo-controlled study显示文摘 | Yogesh M. Shastri Nicolas Hoepffner Angelika Tessmer Hans Ackermann Oliver Schroeder Jürgen Stein | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 11 | How to solve a semi-infinite optimization problem显示文摘 | Oliver Stein | 2012 | European Journal of Operational Research2012，，2： | 1 |
| 12 | Synchronous Todani types I and III choledochal cysts in a 10-month-old-infant: type IVb显示文摘 | Oliver B. Lao Sharon Stein Kim A. Ely Harold N. Lovvorn | 2008 | Pediatric Surgery International2008，，7： | 1 |
| 13 | HAnd Suture Versus STApling for Closure of Loop Ileostomy (HASTA Trial): Results of a Multicenter Randomized Trial (DRKS00000040)显示文摘 | Thorsten L?ffler Inga Rossion Thomas Bruckner Markus K. Diener Moritz Koch Moritz von Frankenberg Julius Pochhammer Oliver Thomusch Thomas Kijak Thomas Simon André L. Mihaljevic Matthias Krüger Erwin Stein Gerald Prechtl René Hodina Walter Michal Roland S | 2012 | Annals of Surgery2012，，5： | 1 |
| 14 | 永不消逝的东方传奇 李小龙显示文摘一颗耀眼的彗星,一个东方的传奇。当全世界的武术爱好者一遍遍念及他的时候,当一部部影视作品不断向他致敬的时候,李小龙,这个名字本身就是一部传奇。2008年,央视斥资50000万元拍摄的40集电视剧《李小龙传奇》即将公映,我们将又一次在荧幕上领略他非凡的风采。当回顾作为一位中华武术传人的李小龙的一生时,我们将永远怀念他那热爱中华、振奋中华的龙的精神和渴望国家强盛的赤子之心。 | Joel Stein Oliver | 2008 | 疯狂英语(阅读版)2008，0，4： | 0 |
| 15 | Upregulation of 25-hydroxyvitamin D_3-1α-hydroxylase by butyrate in Caco-2 cells显示文摘AIM: To investigate the possible involvement of 25-hydroxyvitamin D3-1α-hydroxylase [1α-25(OH)2D3] in butyrate-induced differentiation in human intestinal cell line Caco-2 cells.METHODS: Caco-2 cells were incubated either with 3 mmol/L butyrate and 1 μmol/L 25(OH)2D3 or with 1μmol/L 1α-25(OH)2D3 for various time intervals ranging from 0 to 72 h. Additionally, cells were co-incubated with butyrate and either 25(OH)2D3 or 1α-25(OH)2D3.1α-25(OH)2D3 mRNA was determined semi-quantitatively using the fluorescent dye PicoGreen. Immunoblotting was used for the detection of 1α-25(OH)2D3 protein.Finally, enzymatic activity was measured by ELISA.RESULTS: Both butyrate and 1α-25(OH)2D3 stimulated differentiation of Caco-2 cells after a 48 h incubation period, while 25(OH)2D3 had no impact on cell differentiation. Synergistic effects on differentiation were observed when cells were co-incubated with butyrate and vitamin D metabolite. Butyrate transiently upregulated 1α-25(OH)2D3 mRNA followed by a timely delayed protein upregulation. Coincidently, enzymatic activity was enhanced significantly. The induction of the enzyme allowed for comparable differentiating effects of both vitamin D metabolites.CONCLUSION: Our experimental data pr ovide a further mechanism for the involvement of the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate. The enhancement of 1α-25(OH)2D3 followed by antiproliferative effects of the vitamin D prohormone in the Caco-2 cell line suggest that 25(OH)2D3 in combination with butyrate may offer a new therapeutic approach for the treatment of colon cancer. | Oliver Schr(o|¨)der Sinan Turak Carolin Daniel Tanja Gaschott Jürgen Stein | 2005 | World Journal of Gastroenterology2005，11，45： | 0 |
| 16 | ON KARUSH-KUHN-TUCKER POINTS FOR A SMOOTHING METHOD IN SEMI-INFINITE OPTIMIZATION显示文摘我们为概括 semi-infiniteoptimization 问题的答案学习变光滑的方法从(斯坦因·奥, G。仍然:与内部点技术解决半无限的优化问题,暹罗 J。控制 Optim, 42 (2003 ) , pp。769-788 ) 。它被看弄平的问题的点未必确实集成到原来的问题的 aKarush-Kuhn-Tucker 点的 thatKarush-Kuhn-Tucker,作为能从结果被期望在(F.Facchinei, H. 江, L。Qi:为有平衡限制的数学节目的一个变光滑的方法,数学。编程序, 85 (1999 ) , pp。107-134 ) 。相反,他们可能仅仅收敛到一个 FritzJohn 点。然而,我们给集中 toKarush-Kuhn-Tucker 削尖保证的不同另外的假设。 | Oliver Stein | 2006 | Journal of Computational Mathematics2006，24，6： | 0 |
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