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| 1 | Gastric cancer with peritoneal metastases: Efficiency of standard treatment methods显示文摘BACKGROUND Peritoneal metastasis(PM),arising from gastric cancer(GC),is the most common pattern of synchronous and metachronous dissemination and is generally associated with poor prognosis.New therapeutic modalities are being increasingly employed for such patients.AIM To develop more advanced methods,it becomes necessary to study the results of existing standard treatment methods in patients with PM in order to perform a comparative analysis of the strategies.METHODS A retrospective analysis of the efficiency of standard treatment methods(i.e.,palliative chemotherapy,palliative gastrectomy,and the best supportive care)was performed on 200 GC patients with synchronous PM.RESULTS The overall survival(OS)rate in 200 GC patients with PM under standard treatment was 5.4 mo.One-year survival occurred in 18.4%of patients.In multivariate analysis,the survival rate was significantly influenced by the following factors:Presence of extraperitoneal metastases,and stage of PM according to both the Japanese Gastric Cancer Association(JGCA)and the peritoneal cancer index(PCI).The median OS and 1-year survival of patients withР1,P2,and P3(JGCA)carcinomatosis were 9.8 mo,6.7 mo,and 4.0 mo,and 47.2%,18.8%,and 5.1%,respectively.The application of the palliative gastrectomy resulted in an increase in the median OS by up to 17 mo compared to the conservative approach where the value was 8.5 mo(P=0.05)in patients withР1РМ.In patients withР3,palliative chemotherapy increased the OS by up to 5.6 mo compared to the OS of 3.2 mo(P=0.0006)for best supportive care.The median OS and 1-year survival of patients withРCI of 1-6,7-12 and 13+points were 8.5 mo,4.2 mo,and 4.1 mo,and 39.8%,6.7%,and 5.5%,respectively.Palliative gastrectomy increased the median OS to 12.6 mo compared to conservative approach of 8.0 mo(P=0.03)in patients withРCI of 1-6 points.In patients withРCI 13+points,only palliative chemotherapy increased the OS to 6.0 mo compared to the OS of 3.4 mo for best supportive care(P=0.0008).CONCLUSION GC patients with PM are characterized by extremely poor prognoses.Long-term survivors were found in the group with PCI of 1-6 points,and there was no survival difference in groups with PCI 7-12 vs PCI 13+points.Palliative gastrectomy could prove effective in treating patients with early stage PM.The three standard treatment methods are equally effective for moderate stages of PM.In cases with advanced peritoneal carcinomatosis,a significant increase in prognosis was registered only after treatment with palliative chemotherapy. | Roman Yarema МyronОhorchak Petro Hyrya Yuriy Kovalchuk Victor Safiyan Ivan Karelin Severyn Ferneza Markiyan Fetsych Myron Matusyak Yuriy Oliynyk Тaras Fetsych | 2020 | World Journal of Gastrointestinal Oncology2020，12，5： | 3 |
| 2 | MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells显示文摘 | Zirath H Frenzel A Oliynyk G | | Proc Natl Acad Sci U S A0，110，10： | 1 |
| 3 | Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea显示文摘 | L J Weissman KJ Hong H Oliynyk M | 2004 | Chembiochem2004，5，1： | 1 |
| 4 | Ligament creep cannot be predicted from stress relaxation at low stress:a biomechanical study of the rabbit medial collateral ligament显示文摘 | Thornton G M Oliynyk A Frank C B | | 0，，05： | 1 |
| 5 | Is ATP a signalling agent in plants? 显示文摘 | DEMIDCHIK V NICHOLS C OLIYNYK M | 2003 | Plant Physiology2003，133，： | 1 |
| 6 | A hybrid modular polyketide synthase obtained by domain swapping显示文摘 | Oliynyk M Brown M J Cortes J | 1996 | Chem Biol1996，3，： | 1 |
| 7 | Complete genome sequence of the erythromyein-producing bacterium Saccharopolyspora erythraea NRRL23338 显示文摘 | Oliynyk M Samborskyy M Lester J B | 2007 | Nat Biotechnol2007，25，4： | 1 |
| 8 | Electronic structure and optical properties of Ti-doped phosphate crystals 显示文摘 | Hizhnyi Y Oliynyk A Gomenyuk O | 2007 | Materials Science and Engineering B2007，144，1： | 1 |
| 9 | Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338显示文摘 | Oliynyk M Samborskyy M Lester JB | 2007 | Nat Biotechnol2007，25，4： | 1 |
| 10 | Hyperthermic intraperitoneal chemoperfusion in combined treatment of locally advanced and disseminated gastric cancer: Results of a single-centre retrospective study显示文摘 | Roman Romanovych Yarema Myron A. Ohorchak Gennadyi P. Zubarev Yuriy P. Mylyan Yuriy Y. Oliynyk Mykola G. Zubarev Petro I. Gyrya Yuriy J. Kovalchuk Victor I. Safiyan Taras G. Fetsych | 2014 | International Journal of Hyperthermia2014，，3： | 1 |
| 11 | Identification of a phosphopantethcinyl transfcrase for crythromycin biosynthesis in Saccharopolyspora erythraea 显示文摘 | Weissman K J Hong H Oliynyk M | 2004 | Chem Biochem2004，5，1： | 1 |
| 12 | Com- plete genome sequence of the erythromy- cin-producing bacterium Saccharopolyspora eryth- raea NRRL2338显示文摘 | Oliynyk M Samborskyy M Lester JB | 2007 | Nature Biotechnology2007，，25： | 1 |
| 13 | The pharmacology of Actoprotectors : practical ap- plication for improvement of mental and physical performance显示文摘 | Oliynyk S Oh S | 2012 | Biomoleeules & therapeutics2012，20，9： | 1 |
| 14 | Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338显示文摘 | Oliynyk M Samborskyy M Lester J B | 2007 | Nat Biotech2007，25，4： | 1 |
| 15 | Complete genome sequence of the erythromyein-producing bacterium Saccharopolyspora erythraea NRRL23338 显示文摘 | Oliynyk M Samborskyy M Lester J B | 2007 | Nat Biotechnol2007，25，4： | 1 |
| 16 | Complete genome sequence of the erythromycin-producing bacterium Sacchropolyspora erythraea NRRL23338显示文摘 | Oliynyk M Samborskyy M Lester JB | 2007 | Nat Biotechnol2007，，4： | 1 |
| 17 | MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells显示文摘 | Zirath H Frenzel A Oliynyk G | 2013 | Proc Natl Acad Sci U S A2013，110，10： | 1 |
| 18 | A hybrid modular polyketide synthase obtained by domain swapping显示文摘 | Oliynyk M Brown M J Cortes J | 1996 | Chem Biol1996，3，10： | 1 |
| 19 | A transparent hybrid of nanocrystalline cellulose and amorphous calcium carbonate nanoparticles显示文摘 | GEBAUER D OLIYNYK V SALAJKOVA M | | 0，，09： | 1 |
| 20 | Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338显示文摘 | OLIYNYK M SAMBORSKYY M LESTER J B | 2007 | Nature Biotechnology2007，25，4： | 1 |
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